miR‐125b Loss Activated HIF1α/pAKT Loop, Leading to Trans‐Arterial Chemoembolization Resistance in Hepatocellular Carcinoma

Scientists aimed to identify key molecular signatures and related pathways leading to hepatocellular carcinoma resistance to trans‐arterial chemoembolization (TACE), with the hope of developing effective approaches in pre‐selecting patients with survival benefit from TACE.
[Hepatology]
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Melanoma Stem Cell Maintenance and Chemo-Resistance Are Mediated by CD133 Signal to PI3K-Dependent Pathways

The functional analysis of CD133+ and CD133 cells in vitro and in vivo revealed that melanoma progression and treatment resistance are the consequences of CD133 signal to PI3K pathway.
[Oncogene]
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CDK5RAP3 as Tumor Suppressor Negatively Regulates Self-Renewal and Invasion and Is Regulated by ERK1/2 Signaling in Human Gastric Cancer

Researchers showed that CDK5 regulatory subunit-associated protein 3 was weakly expressed in gastric cancer stem-like cells (CSCs) and was negatively correlated with the gastric CSC marker CD44.
[British Journal of Cancer]
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TGF-β Induced EMT and Stemness Characteristics are Associated with Epigenetic Regulation in Lung Cancer

Scientists determined whether EMT and stemness characteristics induced by TGF-β might be associated with epigenetic regulation in lung cancer.
[Scientific Reports]
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JAM-A Functions as a Female Microglial Tumor Suppressor in Glioblastoma

Investigators studied the role of microenvironmental junctional adhesion molecule-A (JAM-A) in mediating glioblastoma growth.
[Neuro-Oncology]
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Protein Sumoylation with SUMO1 Promoted by Pin1 in Glioma Stem Cells Augments Glioblastoma Malignancy

Researchers investigated the protein sumoylation status, the major sumoylated substrate and the key regulatory enzyme in glioma stem cells to explore the therapeutic potential of disrupting protein sumoylation for glioblastoma treatment.
[Neuro-Oncology]
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Radiotherapy Targeting Cancer Stem Cells “Awakens” Them to Induce Tumor Relapse and Metastasis in Oral Cancer

Researchers summarzse methods for the identification of oral CSCs and then focus on the characteristics of a CSC subpopulation induced by radiation, hereafter referred to as “awakened” CSCs, to highlight their response to radiotherapy and potential role in tumor recurrence and metastasis post-radiotherapy as well as potential therapeutics targeting CSCs.
[International Journal of Oral Science]
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Cytochrome P450 1B1 Polymorphism Drives Cancer Cell Stemness and Patient Outcome in Head-and-Neck Carcinoma

From head-and-neck squamous cell carcinoma cell lines not expressing CYP1B1, investigators generated isogenic derivatives expressing the two forms. Proliferation, invasiveness, stem cell characteristics, sensitivity to anticancer agents and transcriptome were analyzed.
[British Journal of Cancer]
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Signaling Inhibitors Accelerate the Conversion of Mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment

Inhibition of Erk1/2, tyrosine kinase, and/or GSK-3β was implied to be involved in the enhancement of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemness, and subsequent conversion of mouse iPSCs into cancer stem cells in the tumor microenvironment.
[Scientific Reports]
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Isoprenylcysteine Carboxylmethyltransferase Is Required for the Impact of Mutant KRAS on TAZ Protein Level and Cancer Cell Self-Renewal

The authors found that suppression of isoprenylcysteine carboxylmethyltransferase resulted in reduced self-renewal/stemness in KRAS-driven pancreatic and breast cancer cells.
[Oncogene]
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Targeting Lung Cancer Stem Cells Using Combination of Tel and Docetaxel Liposomes in 3D Cultures and Tumor Xenografts

Scientists demonstrated for the first time the efficacy of Docetaxel liposomes in combination with telmisartan in 3D cultures of H460 cells by using polysaccharide-based hydrogels and also in xenograft model of Docetaxel resistant H460 derived CD133+ lung tumors.
[Toxicology and Applied Pharmacology]
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