cancer stem cells

[Gastric Cancer] Researchers established oxaliplatin resistant gastric cancer organoids and evaluated their gene expression profile using microarray analysis.

[Scientific Reports] The authors demonstrated that FOSL1 directly regulated four transcription factors bond to their promoter regions, was involved in the deregulation of several stemness markers, and reduced the cells’ ability to generate aggregates increasing the extracellular matrix component FN1.

[Gene] Scientists evaluated the NANOG inhibition by siRNA and the increase of Let-7a by miRNA mimic in breast cancer cell lines and the effects of these changes on biologic aspects like apoptosis, stemness and invasion of these cells.

[Journal of Clinical Investigation] Because the environmental and lifestyle factors that impact CSC populations are not clear, scientists sought to understand the consequences of diet on CSC enrichment.

[Journal of Gastroenterology and Hepatology] Scientists investigated the Regorafenib resistance mechanism of CSCs in hepatocellular carcinoma. They used sphere formation and soft agar colony formation assays to evaluate the stemness capacity of cancer cells.

[British Journal of Cancer] Investigators established prostate cancer (PCa) models via the orthotopic and subcutaneous implantation of different human PCa cancer cell lines, and compared the metastatic efficacy, after which process function analysis of target genes was pinpointed.