cancer stem cells

[Cell Death & Differentiation] Scientists illustrated that HIF-2α, but not HIF-1α, induced stemness in breast cancer cells under hypoxia through SOD2-mtROS-PDI/GRP78-UPRER pathway, linking mitochondrial metabolic state to endoplasmic reticulum (ER) response via mitochondrial reactive oxygen species (mtROS) level.

[Clinical Cancer Research] The authors tested if inhibition of DOT1L, an epigenetic regulator of normal tissue stem/progenitor populations, would target triple-negative breast cancers stem cells.

[Cancer Cell International] Researchers reported that macrophages, upon interaction with breast cancer cells, activated tumor promoting functions and exhibited differential expression of various proteins as shown by secretome analysis using proteomics studies.

[Nature Communications] Researchers demonstrated that the breast CSC secretome autonomously compressed the stem cell population.

[BMC Cancer] RAB3B was identified as an up-regulated gene in both cancer stem-like sphere cells and prognostically poor hepatocellular carcinoma by RNA-sequencing.

[Carcinogenesis] Scientists review the evolution of tools to evaluate CSCs in liver cancers, discuss their contributions and limitations, as well as their combined and complementary utilization with techniques like human tumor organoid culture.