cancer stem cells

[British Journal of Cancer] The authors suggest that chronic diseases, including obesity and diabetes, establish the cancer-inducing niche that drives the undifferentiated/progenitor cells into CSCs, which then develop malignant tumours in vivo.

[Molecular Biology Reports] Investigators suggest that hypoxia-induced autophagy and CSCs proliferation should be elucidated in order to find a novel cure to defeat cancer cells.

[Cell Biochemistry and Function] Researchers employed miPS-Huh7cmP cells to reevaluate the efficacy of diphenyleneiodonium since CSCs are currently one of the main foci of therapeutic strategy to treat cancer, but generally considered resistant to chemotherapy.

[Stem Cells] Scientists suggested that the asymmetric distribution of pericentrosomal CD133 endosomes induced the symmetry breaking of autophagic activity during cytokinesis in cooperation with nuclear β-catenin.

[Cell Reports] Investigators showed that collapsin response mediator protein 2A (CRMP2A) was unexpectedly and reversibly induced in cancer cells in response to multiple metabolic stresses, including low glucose and hypoxia, and inhibited EMT/stemness.

[Stem Cell Reports] Scientists identified miR-148a as a targetable element upstream of pregnane X receptor (PXR) signaling in CSCs, which when over-expressed decreased PXR expression and impaired tumor relapse after chemotherapy in mouse tumor xenografts.