microRNA-124-3p Attenuates Myocardial Injury in Sepsis via Modulating SP1/HDAC4/HIF-1α Axis

Septic rats were modeled by cecal ligation puncture while in vitro septic cardiomyocyte H9C2 were induced by lipopolysaccharide.
[Cell Death Discovery]
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LncRNA XR_596701 Protects H9c2 Cells against Intermittent Hypoxia-Induced Injury through Regulation of the miR-344b-5p/FAIM3 Axis

Gene expressions of XR_596701 and miR-344b-5p were detected by quantitative real-time polymerase chain reaction in intermittent hypoxia-induced H9c2 cells.
[Cell Death Discovery]
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Cardiomyocyte IL-1R2 Protects Heart from Ischemia/Reperfusion Injury by Attenuating IL-17RA-Mediated Cardiomyocyte Apoptosis

After myocardial ischemia reperfusion surgery, IL-1R2 expression was significantly increased in heart of wild-type mice.
[Cell Death & Disease]
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Mechanism of miR-378a-3p Enriched in M2 Macrophage-Derived Extracellular Vesicles in Cardiomyocyte Pyroptosis after MI

An in vitro cell model was established, followed by a comprehensive evaluation of cell viability and pyroptosis. The binding relationships of miR-378a-3p and ELAVL1, HuR, and NLR family pyrin domain containing 3 were analyzed.
[Hypertension Research]
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Intrinsic Cardiac Adrenergic Cells Contribute to LPS-Induced Myocardial Dysfunction

Researchers showed that norepinephrine secretion from intrinsic cardiac adrenergic cells was increased through activation of Toll-like receptor 4 to aggravate myocardial TNF-α production and dysfunction by lipopolysaccharide (LPS).
[Communications Biology]
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LncRNA ROR Modulates Myocardial Ischemia-Reperfusion Injury Mediated by the miR-185-5p/CDK6 Axis

Researchers revealed that hypoxia/reoxygenation (H/R) treated human cardiac myocytes showed a significantly decreased miR-185-5p expression and increased expression of CDK6 and ROR.
[Laboratory Investigation]
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Lycium barbarum Polysaccharide Antagonizes Cardiomyocyte Apoptosis by Inhibiting the Upregulation of GRK2 Induced by I/R Injury, and Salvage Mitochondrial Fission/Fusion Imbalance and AKT/eNOS Signaling

Scientists found that Lycium barbarum polysaccharide limited myocardial infarct size, improved adverse remodeling, and reduced cell death and oxidative stress.
[Cellular Signalling]
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Single-Cell Sequencing Reveals Lineage-Specific Dynamic Genetic Regulation of Gene Expression during Human Cardiomyocyte Differentiation

During a dynamic process such as cellular differentiation, the overall cell type composition of a tissue (or an in vitro culture) and the gene regulatory profile of each cell can both experience significant changes over time.
[PLoS Genetics]
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Overexpression of the SARS-CoV-2 Receptor Angiotensin Converting Enzyme 2 in Cardiomyocytes of Failing Hearts

Scientists examined the expression of ACE2 in normal hearts and hearts from patients with terminal heart failure.
[Scientific Reports]
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A20 (TNFAIP3) Alleviates Viral Myocarditis through ADAR1/miR-1a-3p-Dependent Regulation

A20 was underexpressed and miR-1a-3p was overexpressed in the myocardium of VMC mice as well as in Coxsackie virus B3-infected cardiomyocytes.
[BMC Cardiovascular Disorders]
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Roles and Potential Clinical Implications of Tissue Transglutaminase in Cardiovascular Diseases

Scientists summarize recent advances in tissue transglutaminase and discuss its role and mechanisms in the progression of various cardiovascular disease and its potential as a diagnostic and therapeutic target.
[Pharmacological Research]
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