Tag Archives: cardiomyocytes

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Hypertrophic Cardiomyopathy β-Cardiac Myosin Mutation (P710R) Leads to Hypercontractility by Disrupting Super Relaxed State

The authors focused on the P710R mutation that dramatically decreased in vitro motility velocity and actin-activated ATPase, in contrast to other β-cardiac myosin mutations. Human induced pluripotent stem cell–cardiomyocytes with the P710R mutation produced significantly increased force compared with isogenic control cells.

[Proceedings of the National Academy of Sciences of the United States of America]

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Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury

Cultured neonatal rat ventricular myocytes (NRVMs) were exposed to Tat-Beclin during simulated ischemia/reperfusion injury. ATG7 knockdown by siRNA in NRVMs was used to evaluate the role of autophagy.

[Circulation Research]

Abstract

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Review

The Multifaceted View of Heart Problem in Duchenne Muscular Dystrophy

Investigators discuss the multifaceted heart problem in the course of Duchenne muscular dystrophy, balancing the insights into basic science, translational efforts and clinical manifestation of dystrophic heart disease.

[Cellular and Molecular Life Sciences]

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industry & policy

Heartseed Raises $37 Million in Series C Funding to Accelerate Development of iPSC-Derived Stem Cell Therapy for Heart Failure

Heartseed, Inc., a biotechnology company developing iPSC-derived cardiomyocytes for heart failure, announced it has raised approx. $37 Million at Series C round. These funds will accelerate the initiation of a global clinical trial of HS-001, an allogeneic iPSC-derived, highly purified ventricular cardiomyocyte spheroids for heart failure.

[Heartseed, Inc.]

Press Release

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Arrhythmogenic and Antiarrhythmic Actions of Late Sustained Sodium Current in the Adult Human Heart

The authors investigated the role of late sodium current conductance in arrhythmias using adult primary cardiomyocytes and tissues from donor hearts.

[Scientific Reports]

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Emergent Synchronous Beating Behavior in Spontaneous Beating Cardiomyocyte Clusters

Researchers investigated the dominant rule determining synchronization of beating intervals of cardiomyocytes after the clustering of mouse primary and human embryonic stem cell-derived cardiomyocytes.

[Scientific Reports]

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Abstract Full Article Graphical Abstract

A Consolidated Aav System for Single Cut CRISPR Correction of a Common Duchenne Muscular Dystrophy Mutation

Scientists devised a single cut gene editing method using a compact Staphylococcus aureus Cas9 to restore the open reading frame of exon 51, the most commonly affected out-of-frame exon in Duchenne muscular dystrophy. Editing of exon 51 in cardiomyocytes revealed a strong preference for exon reframing via a two nucleotide deletion.

[Molecular Therapy-Methods & Clinical Development]

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A Small Molecule Inhibitor of Nox2 and Nox4 Improves Contractile Function after Ischemia–Reperfusion in the Mouse Heart

Investigators identified a new compound that inhibited reactive oxygen species production in isolated mouse cardiomyocytes and improved cardiomyocyte contractility and contraction of whole retrogradely perfused hearts after a global ischemia period.

[Scientific Reports]

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Visualization of β-Adrenergic Receptor Dynamics and Differential Localization in Cardiomyocytes

Scientists employed highly sensitive fluorescence spectroscopy approaches, in combination with a fluorescent β‐AR antagonist, to determine the presence and dynamics of the endogenous receptors on the outer plasma membrane as well as on the T-tubular network of intact adult cardiomyocytes.

[Proceedings of the National Academy of Sciences of the United States of America]

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Endothelial-Derived Cardiovascular Disease-Related microRNAs Elevated with Prolonged Sitting Pattern among Postmenopausal Women

Researchers explored the association between sitting patterns and microRNAs isolated from endothelial cell-derived extracellular vesicles.

[Scientific Reports]