Researchers investigated the effects of two different types of protein kinase C (PKC) activators, the isophthalate derivative HMI-1b11 and bryostatin-1, on cardiomyocyte hypertrophy and elucidated the role of cPKCs and nPKCs in endothelin-1-induced hypertrophy in vitro.
[Frontiers in Pharmacology]
Pohjolainen, L., Easton, J., Solanki, R., Ruskoaho, H., & Talman, V. (2021). Pharmacological Protein Kinase C Modulators Reveal a Pro-hypertrophic Role for Novel Protein Kinase C Isoforms in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Frontiers in Pharmacology, 11. https://doi.org/10.3389/fphar.2020.553852 Cite
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