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Stem Cell Conversion to the Cardiac Lineage Requires Nucleotide Signaling from Apoptosing Cells

[Nature Cell Biology] Investigators observed that initiation of differentiation in iPSCs and ESCs triggered widespread apoptosis, followed by a synchronous epithelial–mesenchymal transition.

A Small-Molecule Cocktail Promotes Mammalian Cardiomyocyte Proliferation and Heart Regeneration

[Cell Stem Cell] Investigators reported a chemical cocktail of five small molecules that promoted adult cardiomyocyte proliferation and heart regeneration.

ICA69 Aggravates Ferroptosis Causing Septic Cardiac Dysfunction via STING Trafficking

[Cell Death Discovery] Scientists confirmed that LPS significantly enhanced the expression of islet cell autoantigen 69 (ICA69) in wild-type mice, macrophages, and cardiomyocytes.

Cardioprotective Effect of Extracellular Vesicles Derived from Ticagrelor-Pretreated Cardiomyocyte on Hyperglycemic Cardiomyocytes through Alleviation of Oxidative and Endoplasmic Reticulum Stress

[Scientific Reports] Scientists investigated the anti-oxidative and cardioprotective effect of extracellular vesicles derived from ticagrelor-pretreated cardiomyocytes under diabetes mellitus conditions.

Tomatidine-Stimulated Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes for Modeling Mitochondrial Dysfunction

[Experimental and Molecular Medicine] To enhance the maturation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs), the authors identified a natural steroidal alkaloid, tomatidine, as a new substance that stimulated the maturation of hESC-CMs.

LncRNA FAF Attenuates Hypoxia/Ischaemia-Induced Pyroptosis via the miR-185-5p/PAK2 Axis in Cardiomyocytes

[Journal of Cellular and Molecular Medicine] Investigators explored the antipyroptotic effects of long noncoding RNA (lncRNA) FGF9-associated factor (FAF) in acute myocardial infarction.