Repression of Osmr and Fgfr1 by miR-1/133a Prevents Cardiomyocyte Dedifferentiation and Cell Cycle Entry in the Adult Heart

Scientists demonstrated that suppression of FGFR1 and OSMR by miR-1/133a was instrumental to prevent cardiomyocyte dedifferentiation and cell cycle entry in the adult heart.
[Science Advances]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

A CRISPR/Cas9 Strategy for the Generation of a FLNC Knockout hESC Line (WAe009-a-70) to Model Dilated Cardiomyopathy and Arrhythmogenic Right Ventricular Cardiomyopathy

To further understand the exact role of FLNC in dilated cardiomyopathy, scientists generated a human FLNC knockout cell line from the original ESC line H9 by CRISPR/Cas9 gene editing technology.
[Stem Cell Research]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

METTL3 Improves Cardiomyocyte Proliferation upon Myocardial Infarction via Upregulating miR-17-3p in a DGCR8-Dependent Manner

Due to the role of methyltransferase-like 3 (METTL3) in the physiological proliferation of cardiomyocytes, researchers aimed to determine whether METTL3 could also promote cardiomyocyte proliferation under pathological conditions and to elucidate the underlying mechanism.
[Cell Death Discovery]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Cell Proliferation Fate Mapping Reveals Regional Cardiomyocyte Cell-Cycle Activity in Subendocardial Muscle of Left Ventricle

Scientists found that the majority of cycling cardiomyocytes were positioned in the subendocardial muscle of the left ventricle, especially in the papillary muscles
[Nature Communications]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

The circRNA CNEACR Regulates Necroptosis of Cardiomyocytes through Foxa2 Suppression

Scientists found that the level of mmu_circ_000338, a cardiac- necroptosis-associated circRNA, was reduced in hypoxia-reoxygenation exposed cardiomyocytes and ischemia-reperfusion-injured mice hearts.
[Cell Death & Disease]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

In Vitro CSC-Derived Cardiomyocytes Exhibit the Typical microRNA-mRNA Blueprint of Endogenous Cardiomyocytes

The down-regulation of cell cycle genes and the up-regulation of the mature myofilament genes in cardiomyocytes in vitro (iCMs) reached intermediate levels between those of fetal and neonatal cardiomyocytes. Cardiomyo-miRs were up-regulated in iCMs.
[Communications Biology]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Construction of Extracellular Matrix-Based 3D Hydrogel and Its Effects on Cardiomyocytes

Researchers studied the construction of cardiac ECM-based 3D hydrogel and its effects on cell behaviors. The results indicated that cellular compartments could be efficiently removed from heart tissue via sodium dodecyl sulfonate- and Triton X-100-mediated decellularization, remaining the natural fibrous network structure and major proteins.
[Experimental Cell Research]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

Chronic Ethanol Exposure Induces Deleterious Changes in Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells

Understanding biological mechanisms involved in the long-term alcohol exposure-induced cardiotoxicity is pivotal to the discovery of therapeutic strategies. Cardiomyocytes derived from human pluripotent stem cells were treated with clinically relevant doses of ethanol for various durations up to five weeks.
[Stem Cell Reviews and Reports]
[zotpress userid=” items=’BGD4AQBW’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Methyltransferase-Like 3 (METTL3) Attenuates Cardiomyocyte Apoptosis with Myocardial Ischemia-Reperfusion (I/R) Injury through miR-25-3p and miR-873-5p

Researchers showed that methyltransferase-like 3 (METTL3) was downregulated in mice ischemia-reperfusion (I/R) myocardial tissues and hypoxic/re-oxygenated (H/R) cardiomyocytes, and upregulation of METTL3 attenuated I/R and H/R-induced cell apoptosis.
[Cell Biology International]
[zotpress userid=” items=’8UZQXGQ2′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Cell Differentiation in the Cardiac Embryonic Stem Cell Test (ESTc) Is Influenced by the Oxygen Tension in Its Underlying Embryonic Stem Cell Culture

Scientists investigated the chemical sensitivity of the ESTc carried out under 20% O2, using ESCs cultured under either 20% O2 or 5% O2. ESC viability was more sensitive to valproic acid but less sensitive to flusilazole when cultured under 5% versus 20% O2.
[Toxicology in Vitro]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Inhibition of MicroRNA-30a Alleviates Vascular Remodeling in Pulmonary Arterial Hypertension

Researchers investigated the role of miR-30a in the pulmonary artery smooth muscle cells remodeling of pulmonary arterial hypertension.
[Molecular Therapy-Nucleic Acids]
[zotpress userid=” items=’U88MCNBB’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share
Share