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cardiomyocytes

Single-Cell Sequencing Reveals Lineage-Specific Dynamic Genetic Regulation of Gene Expression during Human Cardiomyocyte Differentiation

[PLoS Genetics] During a dynamic process such as cellular differentiation, the overall cell type composition of a tissue (or an in vitro culture) and the gene regulatory profile of each cell can both experience significant changes over time.

Overexpression of the SARS-CoV-2 Receptor Angiotensin Converting Enzyme 2 in Cardiomyocytes of Failing Hearts

[Scientific Reports] Scientists examined the expression of ACE2 in normal hearts and hearts from patients with terminal heart failure.

A20 (TNFAIP3) Alleviates Viral Myocarditis through ADAR1/miR-1a-3p-Dependent Regulation

[BMC Cardiovascular Disorders] A20 was underexpressed and miR-1a-3p was overexpressed in the myocardium of VMC mice as well as in Coxsackie virus B3-infected cardiomyocytes.

Roles and Potential Clinical Implications of Tissue Transglutaminase in Cardiovascular Diseases

[Pharmacological Research] Scientists summarize recent advances in tissue transglutaminase and discuss its role and mechanisms in the progression of various cardiovascular disease and its potential as a diagnostic and therapeutic target.

Base Editing of Human Pluripotent Stem Cells for Modeling Long QT Syndrome

[Stem Cell Reviews and Reports] Researchers described an optimized stepwise protocol to introduce disease-specific mutations of long QT syndrome into human PSCs.

Skeletal Muscle Derived Musclin Protects the Heart during Pathological Overload

[Nature Communications] Scientists investigated whether the dysregulation of myokine expression from wasting skeletal muscle exaggerated heart failure.

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