cardiomyocytes

[Basic Research in Cardiology] Researchers identified that the molecular machinery for membrane protein synthesis occurs throughout the cardiac myocyte, and enabled distributed synthesis of membrane proteins within sub-cellular niches where the synthesized protein functions using local mRNA pools trafficked, in part, by microtubules.

[Nature Communications] Researchers developed a platform of micron-scale cardiac muscle bundles to control biomechanics in arrays of thousands of purified, independently contracting cardiac muscle strips on two-dimensional elastomer substrates with far greater throughput than single cell methods.

[Cell Death Discovery] Researchers demonstrated that fortilin sustained cardiomyocyte survival at least partly through inhibition of p53 and p53-dependent apoptosis.

[Molecular Medicine Reports] hsa_circ_105039 was underexpressed in the heart tissue of patients with congenital heart disease. Investigators found that hsa_circ_105039 overexpression promoted cell differentiation, viability and migration; whereas apoptosis was simultaneously repressed.

[Journal of Virology] Scientists infected hiPSC-derived cardiomyocytes, from healthy human subjects, with SARS-CoV-2 in the absence and presence of IL-6 and IL-1β. Infection resulted in increased numbers of multinucleated cells.

[Histology and Histopathology] Researchers reported that TUG1 expression was induced in mouse heart following myocardial ischemia/reperfusion injury as well as in cardiomyocytes subjected to simulated ischemia/reperfusion in vitro.