cardiomyocytes

[Tissue Engineering Part B-Reviews] Scientists discuss major factors to consider for the development of cardiovascular tissues from stem cell derived cardiomyocytes, examine important considerations in undertaking a cardiovascular tissue engineering project, and present, interpret, and summarize some of the recent advancements in this field.

[Cell Research] Research demonstrated that atrial cardiomyocytes have an intrinsic glutamatergic transmitter system, which regulated the generation and propagation of action potentials.

[Archives of Toxicology] Researchers presented the generation and application of a fluorescent human iPSC reporter line for heme oxygenase-1, which is considered a sensitive and reliable biomarker for the oxidative stress response.

[Scientific Reports] The Hippo pathway regulates the proliferation of cancer cells, pluripotent stem cells, and epithelial cells through a cell–cell contact-dependent manner, however, it is unclear if cell density-dependent cell proliferation is a consistent feature in cardiac myocytes. Scientists used cultured human iPSC-derived cardiac myocytes as a model system to investigate this concept.

[Stem Cell Reviews and Reports] The chromatin accessibility and transcriptional level of human ESCs and human urine cells were compared by Assay for Transposase-Accessible Chromatin with high-throughput sequencing and RNA sequencing RNA-seq to identify potential reprogramming factors.

[Cell Death & Disease] Researchers found that a dietary saturated fatty acid, palmitate increased intracellular cAMP synthesis through the palmitoylation of soluble adenylyl cyclase in cardiomyocytes.