cardiomyocytes

[Cell Death & Disease] Scientists investigated the role and underlying molecular basis of osteocrin (OSTN) in diabetic cardiomyopathy. Neonatal rat cardiomyocytes were isolated and stimulated with high glucose to verify the role of OSTN in vitro.

[Proceedings of the National Academy of Sciences of the United States of America] The authors focused on the P710R mutation that dramatically decreased in vitro motility velocity and actin-activated ATPase, in contrast to other β-cardiac myosin mutations. Human induced pluripotent stem cell–cardiomyocytes with the P710R mutation produced significantly increased force compared with isogenic control cells.

[Circulation Research] Cultured neonatal rat ventricular myocytes (NRVMs) were exposed to Tat-Beclin during simulated ischemia/reperfusion injury. ATG7 knockdown by siRNA in NRVMs was used to evaluate the role of autophagy.

[Cellular and Molecular Life Sciences] Investigators discuss the multifaceted heart problem in the course of Duchenne muscular dystrophy, balancing the insights into basic science, translational efforts and clinical manifestation of dystrophic heart disease.

[Heartseed, Inc.] Heartseed, Inc., a biotechnology company developing iPSC-derived cardiomyocytes for heart failure, announced it has raised approx. $37 Million at Series C round. These funds will accelerate the initiation of a global clinical trial of HS-001, an allogeneic iPSC-derived, highly purified ventricular cardiomyocyte spheroids for heart failure.

[Current Stem Cell Research & Therapy] Investigators investigated whether human endometrium-derived stem cells could be used for cardiac repair after ischemic injury and their possible underlying mechanisms.