cardiomyocytes

[Nature Communications] Using a high-throughput phenotypic screen, scientists identified a potent and non-toxic activator of Yap. In vitro kinase assays show that the compound acts as an ATP-competitive inhibitor of Lats kinases-the core enzymes in Hippo signaling.

[Seminars in Cell & Developmental Biology] Investigators focus on the different antitumorigenic and therapeutic aspects of miR-1, including how it regulates tumor development and associated immunomodulatory functions.

[Cell] Investigators established self-organizing cardioids from human pluripotent stem cells that intrinsically specified, patterned, and morphed into chamber-like structures containing a cavity.

[Science Advances] Investigators defined >287,000 candidate cis-regulatory elements (cCREs) in the four chambers of the human heart, which revealed cCREs and candidate transcription factors associated with cardiac cell types in a region-dependent manner and during heart failure.

[Cell Death & Disease] Researchers determined a novel circRNA, circACSL1, which was significantly upregulated in the acute phase of myocarditis, by using lipopolysaccharide to induce inflammatory responses in the human cardiomyocytes line.

[Scientific Reports] Scientists used human induced pluripotent stem cell-derived cardiomyocytes and human cardiac fibroblasts in 3-dimensional microtissues to create an improved in vitro platform for assessing pro-arrhythmic cardiotoxicity.