caspase-3

[Laboratory Investigation] Researchers investigated the effects of bile acids on tissue factor activity and thrombin generation in hepatocytes and correlated these effects with activation of farnesoid X receptor-dependent signaling and apoptosis.

[Scientific Reports] The neuroprotective effect of selumetinib on acrolein-induced neurotoxicity was investigated in vitro using primary cultured cortical neurons.

[Scientific Reports] Expression levels of messenger RNAs and proteins were examined in the ipsilateral cortex, and mimics and inhibitors of selective miRNAs were transfected into Neuro-2a cells before oxygen–glucose deprivation.

[Scientific Reports] Scientists reported the antitumor effects and mechanism of a novel benzothiazole derivative 4-methoxy-cyclohexane carboxylic acid [2-(3,5-dimethyl-isoxazole-4-yl) sulpanil-benzothiazole-6-yl]-amide (PB01) in radiation-resistant human non-small-cell lung cancer cells.

[Scientific Reports] Reserachers investigated the effects of hyperbaric oxygen treatment (HBOT) on solid tumors, such as lung cancer. Non-small cell human lung carcinoma A549-cell-transferred severe combined immunodeficiency mice were selected as an in vivo model to detect the potential mechanism of HBOT in lung tumors.

[Melanoma Research] The aim of this study was to assess the effect of Interleukin-7 signaling on T helper 17 responses in patients with primary cutaneous melanoma.