cell proliferation

[Biomedicine & Pharmacotherapy] Researchers characterized a novel 12-kDa protein that named musarin, which was purified from Trametes versicolor mushroom extract and showed significant growth inhibition on multiple human colorectal cancer cell lines in vitro.

[Molecular Therapy-Nucleic Acids] The authors reported DGUOK-AS1 overexpression promoted breast cancer cell migration, angiogenesis, and macrophage migration, mediated by the increased secretion of IL11, which was extremely important for cancer progression.

[Molecular Medicine] TRIM14 promoted the proliferation of acute myeloid leukemia cells via activating PI3K/AKT pathway, which was reversed by human MSC-derived exosomes through delivering miR-23b-5p.

[Oncogene] Scientists reported that neurogenic differentiation factor 1 (NeuroD1) was positively correlated with glucose-6-phosphate dehydrogenase, the rate-limiting enzyme in the pentose phosphate pathway, in colorectal cancer cells.

[Blood] MB1-47 treatment in T cell acute lymphoblastic leukemia cells robustly inhibited cell proliferation via both cytostatic and cytotoxic effects as a result of compromised mitochondrial energy and metabolite depletion, which severely impaired nucleotide biosynthesis.

[Molecular Medicine Reports] The authors investigated the molecular mech­­anisms of long non‑coding RNA small nucleolar RNA host gene 16 in the proliferation and metastasis of prostate cancer cells.