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cell proliferation

Downregulation of Kcnq1ot1 Attenuates β-Cell Proliferation and Insulin Secretion via the MiR-15b-5p/Ccnd1 and Ccnd2 Axis

[Acta Diabetologica] CCK8, Ki67 staining, immunohistochemical analyses, glucose-stimulated insulin secretion and intraperitoneal glucose tolerance test were performed to detect the effect of Kcnq1ot1 on β-cell proliferation and insulin secretion in vitro and in vivo.

Bevacizumab Attenuates Osteosarcoma Angiogenesis by Suppressing MIAT Encapsulated by Serum-Derived Extracellular Vesicles and Facilitating miR-613-Mediated GPR158 Inhibition

[Cell Death & Disease] Scientists investigated the therapeutic potential of bevacizumab in angiogenesis during osteosarcoma and the related mechanisms.

ATP7B Gene Therapy of Autologous Reprogrammed Hepatocytes Alleviates Copper Accumulation in a Murine Model of Wilson’s Disease

[Hepatology] Scientists evaluated the function and efficacy of autologous reprogrammed, ATP7B gene-restored hepatocytes using a murine model of Wilson's disease.

The Pancreatic Cancer Immune Tumor Microenvironment Is Negatively Remodeled by Gemcitabine While TGF-β Receptor plus Dual Checkpoint Inhibition Maintains Antitumor Immune Cells

[Molecular Carcinogenesis] Scientists hypothesized that TGF-β receptor inhibition may alter Pancreatic ductal adenocarcinoma progression and antitumor immunity in the tumor microenvironment.

Sodium Thiosulfate Acts as a Hydrogen Sulfide Mimetic to Prevent Intimal Hyperplasia via Inhibition of Tubulin Polymerisation

[Ebiomedicine] Sodium thiosulfate, a drug used for the treatment of cyanide poisoning and calciphylaxis, protected against intimal hyperplasia in a mouse model of arterial restenosis and in human vein segments.

Valproic Acid Decreases Vascular Smooth Muscle Cell Proliferation via Protein Phosphatase 2A-Mediated p70 S6 Kinase Inhibition

[Biochemical and Biophysical Research Communications] Scientists investigated the molecular mechanism by which valproic acid inhibited rat vascular smooth muscle cell proliferation.

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