cell transplantation

[Bone Marrow Transplantation] The ASTCT, CIBMTR, and the EBMT, jointly convened an expert panel to formulate consensus recommendations for role, timing, and sequencing of auto-, allo-hematopoietic cell transplantation, and chimeric antigen receptor T-cell therapy for patients with newly diagnosed and relapsed/refractory mantle cell lymphoma.

[Bristol Myers Squibb] Bristol Myers Squibb announced that the FDA has accepted its supplemental Biologics License Application for Orencia for the prevention of moderate to severe aGvHD in patients six years of age and older receiving unrelated donor hematopoietic stem cell transplantation.

[Stem Cell Research & Therapy] The authors evaluate 46 studies including 28 animal works and 18 human trials to explore whether stem cell therapy is effective for animal models and patients with Crohn’s disease.

[Immunity Inflammation and Disease] Graft-versus-host disease (GVHD) was induced in lethally irradiated BALB/c mice. M2 macrophages derived from donor bone marrow (BM) were administered intravenously, while controls received donor BM-mononuclear cells and splenocytes.

[Haematologica] Scientists showed that endoplasmic reticulum stress contributed to intestinal tissue injury during graft-versus-host disease and could be targeted pharmacologically.

[Science Advances] Investigators develop an approach to form organoid from human iPSCs which, when combined with real-time label-free Raman spectroscopy of biochemical composition changes and confocal light scattering spectroscopic microscopy of chromatin transition, allowed for monitoring live differentiating organoids without the need to sacrifice a sample.