chondrocytes

[BMC Cancer] Investigators conducted microarray gene expression analysis and compared FX-9 exposed and unexposed prostate cancer cells, followed by pathway analysis and gene annotation to functional processes.

[Advanced Science] A facile 3D-bioassembly platform was introduced to primarily study fusion of cartilage–cartilage interfaces using spheroids formed from human MSCs and articular chondrocytes.

[Scientific Reports] Scientists demonstrated that short-term exposure to BMP7 decreased the fibrocartilage chondrocyte phenotype. The BMP7-dependent reduction of Collagen type I protein expression seemed MMP2-dependent and inhibition of Smad2/3-PAI1 activity was identified as a potential pathway via which BMP7 exerted its anti-fibrotic action.

[Stem Cell Research & Therapy] The in vitro and in vivo cartilage and bone tissue formation potencies of human PSCs were investigated. The iPSCs were specified towards the mesodermal lineage and differentiated towards chondrocytes, which subsequently self-assembled into cartilaginous organoids.

[Scientific Reports] Researchers developed a robust method to generate 3D, scaffold-free, hyaline cartilage tissue constructs from human ESCs that were composed of numerous chondrocytes in lacunae, embedded in an extracellular matrix containing Type II collagen, sulphated glycosaminoglycans and Aggrecan.

[Cell Death & Disease] The role of FGF21 in the progression of osteoarthritis was investigated in both in vitro and in vivo experiments. In vitro, FGF21 administration alleviated apoptosis, senescence, and ECM catabolism of the chondrocytes induced by tert-butyl hydroperoxide by mediating autophagy flux.