circulating tumor cells

[Molecular Oncology] Co-detection and comprehensive phenotypic and karyotypic molecular characterization of aneuploid circulating tumor cells and circulating tumor endothelial cells were conducted on non-small cell lung cancer patients receiving bevacizumab plus chemotherapy.

[Molecular Cancer] Investigators describe the identification, biological characteristics, and single-cell genome-wide variation in circulating tumor cells and summarizes the application of single-cell sequencing technology to tumor typing, metastasis analysis, progression detection, and adjuvant therapy.

[Nature Communications] ICAM1 expression increased by 200-fold in the lung metastases of three TNBC patient-derived xenografts, and its depletion abrogated lung colonization of TNBC cells by inhibiting homotypic tumor cell-tumor cell cluster formation.

[Lab on a Chip] Researchers describe recent advancements in isolation and detection technology and the strength and weaknesses of the three circulating biomarkers.

[eLife] Scientists demonstrated that oxaliplatin-resistant colorectal cancer cells were sensitized to TRAIL-mediated apoptosis. Oxaliplatin-resistant cells exhibited transcriptional downregulation of caspase-10, but this had minimal effects on TRAIL sensitivity following CRISPR-Cas9 deletion of caspase-10 in parental cells.

[npj Precision Oncology] Researchers provided in-depth investigation of copy number alteration heterogeneity in phenotypically characterized circulating tumor cells at resistance to Anaplastic Lymphoma Kinase (ALK)-tyrosine kinase inhibitors in ALK-positive non-small cell lung cancer.