colorectal cancer cells

[Cancer Research] The authors determined that 14-3-3σ expression was significantly downregulated in primary human colorectal cancer when compared with adjacent normal colonic tissue in patient samples. Downregulation of 14-3-3σ in primary colorectal cancers was significantly associated with p53 mutation, increasing tumor stage, distant metastasis, and poor patient survival.

[Cell Death & Disease] The authors investigated the mechanisms by which PRDX2 promoted the proliferation of colorectal cancer, and found that the oncogenic property of PRDX2 may have been attributed to its regulation of the RPL4-MDM2-p53 pathway, leading to p53 ubiquitinated degradation.

[integrative Biology] The clustering of integrin α5ß1 at the plasma membrane of colorectal cancer-derived epithelial cells modulated their ability to respond to stimulation by receptor tyrosine kinase-activating growth factors EGF, NRG and HGF, through GSK3-mediated suppression of Akt pathway.

[Cellular & Molecular Biology Letters] The effects of worenine on colorectal cancer cell proliferation, colony formation and cell cycle distribution were measured.

[Scientific Reports] Scientists determined how glucose concentration influences cancer cells’ response to metformin. They used two colorectal cancer cell lines with different growth rates and clinically achievable metformin concentrations.

[Scientific Reports] Using a novel screening method, investigators identified novel transcription factors that regulated the intestinal stem cell fate upon endoplasmic reticulum stress.