colorectal cancer

[Nature Communications] Researchers sequenced 73 pairs of colorectal cancer tissues and generated 147 H3K27ac ChIP-Seq, 144 RNA-Seq, 147 whole genome sequencing and 86 H3K4me3 ChIP-Seq samples.

[Cancer Science] Scientists carried out systematic analyses of metabolites in patient-derived colorectal cancer spheroids, and identified high levels of kynurenine and TDO2 that were positively associated with liver metastasis.

[Cell Death & Disease] Ephexin1 was reported to be highly upregulated by oncogenic Ras, but the functional consequences of this remain poorly understood. The authors showed that Ephexin1 was highly expressed in colorectal cancer and lung cancer patient tissues.

[British Journal of Cancer] Scientists explicated a regulatory mechanism of the KLF5 gene product from a view of three-dimensional genome structure in colorectal cancer.

[GenFleet Therapeutics] GenFleet Therapeutics announced the first patient with metastatic sigmoid adenocarcinoma has been dosed in a Phase Ib/II trial of GFH018 in combination with toripalimab as part of global multi-center clinical research. There are broad indications for GFH018 in treating solid tumors with lower response rates to PD-1 inhibitors.

[Molecular Oncology] As toll-like receptor 4 (TLR4) agonists are known to regress solid tumors, scientists observed that lipopolysaccharide induced TOPORS via a TLR4–TRIF-dependent pathway, which in turn modulated the transcription of tumor suppressor scaffold/matrix attachment region-binding protein 1.