RING Finger Protein TOPORS Modulates the Expression of Tumor Suppressor SMAR1 in Colorectal Cancer via the TLR4-TRIF Pathway

As toll-like receptor 4 (TLR4) agonists are known to regress solid tumors, scientists observed that lipopolysaccharide induced TOPORS via a TLR4–TRIF-dependent pathway, which in turn modulated the transcription of tumor suppressor scaffold/matrix attachment region-binding protein 1.