Fetal resistin levels were measured in cord blood from pregnancies with and without maternal diabetes. Secretion of resistin from cord blood mononuclear cells was measured.
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Scientists report that mouse survival of peritoneal Escherichia coli sepsis was compromised by long-chain polyphosphates, and improved with bacterial polyphosphatekinase deficiency or neutralization using recombinant exopolyphosphatase.
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Roewe, J., Stavrides, G., Strueve, M., Sharma, A., Marini, F., Mann, A., Smith, S. A., Kaya, Z., Strobl, B., Mueller, M., Reinhardt, C., Morrissey, J. H., & Bosmann, M. (2020). Bacterial polyphosphates interfere with the innate host defense to infection. Nature Communications, 11(1), 4035. https://doi.org/10.1038/s41467-020-17639-x Cite
Typhi strain were stained with a 33-metal-labeled antibody panel for mass cytometry analyses of the early chromatin modifications modulated by S. Typhi.
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Scientists showed that in the pathological angiogenic vascular niche, retinal myeloid cells, particularly macrophages/microglia that were spatially adjacent to endothelial cells, were highly glycolytic.
[Science Translational Medicine]
The authors showed that the aryl hydrocarbon receptor (AHR) pathway was selectively active in indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2-overexpressing tumors and was associated with resistance to immune checkpoint inhibitors.
Investigators report a copper(II) complex containing a Schiff base ligand and a polypyridyl ligand, 4 capable of inducing immunogenic cell death in breast cancer stem cells.
Investigators confirmed that macrophages from common carp could polarize into M1- and M2 phenotypes with conserved functions and corresponding transcriptional profiles compared to mammalian macrophages.
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Wentzel, A. S., Petit, J., van Veen, W. G., Fink, I. R., Scheer, M. H., Piazzon, M. C., Forlenza, M., Spaink, H. P., & Wiegertjes, G. F. (2020). Transcriptome sequencing supports a conservation of macrophage polarization in fish. Scientific Reports, 10(1), 13470. https://doi.org/10.1038/s41598-020-70248-y Cite
Scientists showed that lipopolysaccharide in combination with IFNγ, inhibited PINK1-dependent mitophagy in macrophages through a STAT1-dependent activation of the inflammatory caspases 1 and 11.
[Journal of Clinical Investigation]
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Patoli, D., Mignotte, F., Deckert, V., Dusuel, A., Dumont, A., Rieu, A., Jalil, A., Dongen, K. V., Bourgeois, T., Gautier, T., Magnani, C., Guern, N. L., Mandard, S., Bastin, J., Djouadi, F., Schaeffer, C., Guillaumot, N., Narce, M., Nguyen, M., … Thomas, C. (2020). Inhibition of mitophagy drives macrophage activation and anti-bacterial defense during sepsis. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI130996 Cite
The authors showed for the first time that the immune response is altered as a result of syngeneic neonatal cardiomyocyte transplantation after myocardial infarction leading to improved cardiac pump function as observed by magnetic resonance imaging in C57BL/6J mice.
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Vasudevan, P., Wolfien, M., Lemcke, H., Lang, C. I., Skorska, A., Gaebel, R., Koczan, D., Lindner, T., Engelmann, R., Vollmar, B., Krause, B. J., Wolkenhauer, O., Lang, H., Steinhoff, G., & David, R. (2020). Cardiomyocyte Transplantation after Myocardial Infarction Alters the Immune Response in the Heart. Cells, 9(8), 1825. https://doi.org/10.3390/cells9081825 Cite
Investigators employed miRNA sponges that were forcibly expressed using a lentiviral vector to knock‐down the expression of miR‐146a in human adipose‐derived stem cells.
[Journal of Tissue Engineering and Regenerative Medicine]
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Wan, S., Wu, Q., Ji, Y., Fu, X., & Wang, Y. (n.d.). Promotion of the immunomodulatory properties and osteogenic differentiation of adipose-derived mesenchymal stem cells in vitro by lentivirus-mediated miR-146a sponge expression. Journal of Tissue Engineering and Regenerative Medicine, n/a(n/a). https://doi.org/10.1002/term.3113 Cite
The three dihydroxystilbenes in this study inhibited colon carcinogenesis and tumor growth as well as increases in colon IL-1β, IL-6, MCP-1, and PD-1 levels in AOM/DDS-treated mice in vivo. The three dihydroxystilbenes also suppressed COX-2 expression in colon tumors in vivo and inhibited PD-1 elevations in M2-THP-1 macrophages in vitro.
[European Journal of Pharmacology]
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Kimura, Y., Sumiyoshi, M., Kiyoi, T., & Baba, K. (2020). Dihydroxystilbenes prevent azoxymethane/dextran sulfate sodium-induced colon cancer by inhibiting colon cytokines, a chemokine, and programmed cell death-1 in C57BL/6J mice. European Journal of Pharmacology, 173445. https://doi.org/10.1016/j.ejphar.2020.173445 Cite
Researchers generated distinct imageable syngeneic mouse glioblastoma-tumor models and utilized RNA-sequencing, CyTOF and correlative immunohistochemistry to assess immune-profiles in these models.
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