Fetal Circulating Human Resistin Increases in Diabetes during Pregnancy and Impairs Placental Mitochondrial Biogenesis

Fetal resistin levels were measured in cord blood from pregnancies with and without maternal diabetes. Secretion of resistin from cord blood mononuclear cells was measured.
[Molecular Medicine]
Jiang, S., Teague, A. M., Tryggestad, J. B., Lyons, T. J., & Chernausek, S. D. (2020). Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis. Molecular Medicine, 26(1), 76. https://doi.org/10.1186/s10020-020-00205-y Cite
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Bacterial Polyphosphates Interfere with the Innate Host Defense to Infection

Scientists report that mouse survival of peritoneal Escherichia coli sepsis was compromised by long-chain polyphosphates, and improved with bacterial polyphosphatekinase deficiency or neutralization using recombinant exopolyphosphatase.
[Nature Communications]
Roewe, J., Stavrides, G., Strueve, M., Sharma, A., Marini, F., Mann, A., Smith, S. A., Kaya, Z., Strobl, B., Mueller, M., Reinhardt, C., Morrissey, J. H., & Bosmann, M. (2020). Bacterial polyphosphates interfere with the innate host defense to infection. Nature Communications, 11(1), 4035. https://doi.org/10.1038/s41467-020-17639-x Cite
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Salmonella enterica Serovar Typhi Exposure Elicits Ex Vivo Cell-Type-Specific Epigenetic Changes in Human Gut Cells

Typhi strain were stained with a 33-metal-labeled antibody panel for mass cytometry analyses of the early chromatin modifications modulated by S. Typhi.
[Scientific Reports]
Sztein, M. B., Bafford, A. C., & Salerno-Goncalves, R. (2020). Salmonella enterica serovar Typhi exposure elicits ex vivo cell-type-specific epigenetic changes in human gut cells. Scientific Reports, 10(1), 13581. https://doi.org/10.1038/s41598-020-70492-2 Cite
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Glycolysis Links Reciprocal Activation of Myeloid Cells and Endothelial Cells in the Retinal Angiogenic Niche

Scientists showed that in the pathological angiogenic vascular niche, retinal myeloid cells, particularly macrophages/microglia that were spatially adjacent to endothelial cells, were highly glycolytic.
[Science Translational Medicine]
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Blockade of the AHR Restricts a Treg-Macrophage Suppressive Axis Induced by L-Kynurenine

The authors showed that the aryl hydrocarbon receptor (AHR) pathway was selectively active in indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2-overexpressing tumors and was associated with resistance to immune checkpoint inhibitors.
[Nature Communications]
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Immunogenic Cell Death of Breast Cancer Stem Cells by an Endoplasmic Reticulum‐Targeting Copper(II) Complex

Investigators report a copper(II) complex containing a Schiff base ligand and a polypyridyl ligand, 4 capable of inducing immunogenic cell death in breast cancer stem cells.
[Chembiochem]
Kaur, P., Johnson, A., Northcote-Smith, J., Lu, C., & Suntharalingam, K. (2020). Immunogenic Cell Death of Breast Cancer Stem Cells by an Endoplasmic Reticulum-Targeting Copper(II) Complex. ChemBioChem, n/a(n/a). https://doi.org/10.1002/cbic.202000553 Cite
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Transcriptome Sequencing Supports a Conservation of Macrophage Polarization in Fish

Investigators confirmed that macrophages from common carp could polarize into M1- and M2 phenotypes with conserved functions and corresponding transcriptional profiles compared to mammalian macrophages.
[Scientific Reports]
Wentzel, A. S., Petit, J., van Veen, W. G., Fink, I. R., Scheer, M. H., Piazzon, M. C., Forlenza, M., Spaink, H. P., & Wiegertjes, G. F. (2020). Transcriptome sequencing supports a conservation of macrophage polarization in fish. Scientific Reports, 10(1), 13470. https://doi.org/10.1038/s41598-020-70248-y Cite
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Inhibition of Mitophagy Drives Macrophage Activation and Anti-bacterial Defense during Sepsis

Scientists showed that lipopolysaccharide in combination with IFNγ, inhibited PINK1-dependent mitophagy in macrophages through a STAT1-dependent activation of the inflammatory caspases 1 and 11.
[Journal of Clinical Investigation]
Patoli, D., Mignotte, F., Deckert, V., Dusuel, A., Dumont, A., Rieu, A., Jalil, A., Dongen, K. V., Bourgeois, T., Gautier, T., Magnani, C., Guern, N. L., Mandard, S., Bastin, J., Djouadi, F., Schaeffer, C., Guillaumot, N., Narce, M., Nguyen, M., … Thomas, C. (2020). Inhibition of mitophagy drives macrophage activation and anti-bacterial defense during sepsis. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI130996 Cite
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Cardiomyocyte Transplantation after Myocardial Infarction Alters the Immune Response in the Heart

The authors showed for the first time that the immune response is altered as a result of syngeneic neonatal cardiomyocyte transplantation after myocardial infarction leading to improved cardiac pump function as observed by magnetic resonance imaging in C57BL/6J mice.
[Cells]
Vasudevan, P., Wolfien, M., Lemcke, H., Lang, C. I., Skorska, A., Gaebel, R., Koczan, D., Lindner, T., Engelmann, R., Vollmar, B., Krause, B. J., Wolkenhauer, O., Lang, H., Steinhoff, G., & David, R. (2020). Cardiomyocyte Transplantation after Myocardial Infarction Alters the Immune Response in the Heart. Cells, 9(8), 1825. https://doi.org/10.3390/cells9081825 Cite
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Promotion of the Immunomodulatory Properties and Osteogenic Differentiation of Adipose‐Derived Mesenchymal Stem Cells In Vitro by Lentivirus‐Mediated miR‐146a Sponge Expression

Investigators employed miRNA sponges that were forcibly expressed using a lentiviral vector to knock‐down the expression of miR‐146a in human adipose‐derived stem cells.
[Journal of Tissue Engineering and Regenerative Medicine]
Wan, S., Wu, Q., Ji, Y., Fu, X., & Wang, Y. (n.d.). Promotion of the immunomodulatory properties and osteogenic differentiation of adipose-derived mesenchymal stem cells in vitro by lentivirus-mediated miR-146a sponge expression. Journal of Tissue Engineering and Regenerative Medicine, n/a(n/a). https://doi.org/10.1002/term.3113 Cite
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Dihydroxystilbenes Prevent Azoxymethane/Dextran Sulfate Sodium-Induced Colon Cancer by Inhibiting Colon Cytokines, a Chemokine, and Programmed Cell Death-1 in C57BL/6J Mice

The three dihydroxystilbenes in this study inhibited colon carcinogenesis and tumor growth as well as increases in colon IL-1β, IL-6, MCP-1, and PD-1 levels in AOM/DDS-treated mice in vivo. The three dihydroxystilbenes also suppressed COX-2 expression in colon tumors in vivo and inhibited PD-1 elevations in M2-THP-1 macrophages in vitro.
[European Journal of Pharmacology]
Kimura, Y., Sumiyoshi, M., Kiyoi, T., & Baba, K. (2020). Dihydroxystilbenes prevent azoxymethane/dextran sulfate sodium-induced colon cancer by inhibiting colon cytokines, a chemokine, and programmed cell death-1 in C57BL/6J mice. European Journal of Pharmacology, 173445. https://doi.org/10.1016/j.ejphar.2020.173445 Cite
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Immune Phenotyping of Diverse Syngeneic Murine Brain Tumors Identifies Immunologically Distinct Types

Researchers generated distinct imageable syngeneic mouse glioblastoma-tumor models and utilized RNA-sequencing, CyTOF and correlative immunohistochemistry to assess immune-profiles in these models.
[Nature Communications]
Khalsa, J. K., Cheng, N., Keegan, J., Chaudry, A., Driver, J., Bi, W. L., Lederer, J., & Shah, K. (2020). Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types. Nature Communications, 11(1), 3912. https://doi.org/10.1038/s41467-020-17704-5 Cite
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