tumor associated macrophages

[Cell Death Discovery] TGF-β from tumor-associated macrophages activated RAD18 in triple-negative breast cancer to enhance tumor stemness, forming a positive feedback loop. Inhibition of YAP or TGF-β broke this loop and suppressed cancer stemness and proliferation.

[Cell Death Discovery] Scientists observed that disrupting glioblastoma hyaluronic acid synthesis or blocking HA binding to its receptor CD44 on macrophages increased the proportion of M1 macrophages by upregulating SIRPα in macrophages,

[Cancer Research] Researchers reported that Rab13, a small GTPase, is highly expressed in breast CSCs.

[Nature Communications] Researchers depicted an interplay of molecular, cellular, and tissue microenvironment alterations that increased BRCA1-associated breast cancer risk.

[Nature Reviews Clinical Oncology] Scientists examine the diversity of tumor-associated macrophages (TAM) in various cancer indications and how this heterogeneity is being revisited with the advent of single-cell technologies, and then explore the current knowledge on the functional roles of different TAM states and the prognostic and predictive value of TAM-related signatures.

[Cell] The authors identified a discrete population of FOLR2+ tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors.