Microbiota-Dependent Expansion of Testicular IL-17-Producing Vγ6+ γδ T Cells upon Puberty Promotes Local Tissue Immune Surveillance

Investigators characterized a population of interleukin 17-producing γδ T cells that seeded the testis of naive C57BL/6 mice, expand at puberty and persisted throughout adulthood.
[Mucosal Immunology]
Wilharm, A., Brigas, H. C., Sandrock, I., Ribeiro, M., Amado, T., Reinhardt, A., Demera, A., Hoenicke, L., Strowig, T., Carvalho, T., Prinz, I., & Ribot, J. C. (2020). Microbiota-dependent expansion of testicular IL-17-producing Vγ6 + γδ T cells upon puberty promotes local tissue immune surveillance. Mucosal Immunology, 1–11. https://doi.org/10.1038/s41385-020-0330-6 Cite
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Transplantation of R-GSIK Scaffold with Mesenchymal Stem Cells Improves Neuroinflammation in a Traumatic Brain Injury Model

Investigators determined the ability of the R-GSIK scaffold in supporting the effects of mesenchymal stem cells on motor function activity and inflammatory responses in an experimental traumatic brain injury model.
[Cell and Tissue Research]
Sahab Negah, S., Shirzad, M. M., Biglari, G., Naseri, F., Hosseini Ravandi, H., Hassani Dooghabadi, A., & Gorji, A. (2020). Transplantation of R-GSIK scaffold with mesenchymal stem cells improves neuroinflammation in a traumatic brain injury model. Cell and Tissue Research. https://doi.org/10.1007/s00441-020-03247-0 Cite
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Neural Metabolic Imbalance Induced by MOF Dysfunction Triggers Pericyte Activation and Breakdown of Vasculature

The authors showed that neural-specific depletion of three members of the non-specific lethal chromatin complex—Mof, Kansl2 or Kansl3—unexpectedly led to severe vascular defects and brain hemorrhaging.
[Nature Cell Biology]
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