FAM49B Promotes Breast Cancer Proliferation, Metastasis, and Chemoresistance by Stabilizing ELAVL1 Protein and Regulating Downstream Rab10/TLR4 Pathway

Scientists systematically studied the role of FAM49B in the proliferation, metastasis, apoptosis, and chemoresistance of breast cancer, as well as the corresponding molecular mechanisms and downstream target.
[Cancer Cell International]
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Distinct Single-Component Adjuvants Steer Human DC-Mediated T-cell Polarization via Toll-Like Receptor Signaling toward a Potent Antiviral Immune Response

Scientists assessed the effect of different adjuvants on human monocyte-derived dendritic cells and their ability to polarize innate and adaptive immune responses.
[Proceedings of the National Academy of Sciences of the United States of America]
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Direct Tissue-Sensing Reprograms TLR4+ Tfh-Like Cells Inflammatory Profile in the Joints of Rheumatoid Arthritis Patients

Investigators identified a TLR4+ follicular helper T cell-like population present in the blood and expanded in synovial fluid.
[Communications Biology]
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FSTL1 Secreted by Activated Fibroblasts Promotes Hepatocellular Carcinoma Metastasis and Stemness

Scientists showed follistatin-like 1 (FSTL1) expression to be closely correlated with activated fibroblasts and to be elevated in regenerative, fibrotic, and disease liver states in various mouse models. Consistently, FSTL1 lineage cells gave rise to myofibroblasts in a CCL4-induced hepatic fibrosis mouse model.
[Cancer Research]
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Therapeutic Targeting of the Inflammasome in Myeloid Malignancies

Investigators discuss the role and importance of inflammasomes and immune pathways in myeloid malignancies, particularly myelodysplastic syndromes/acute myeloid leukemia, to better understand the disease pathophysiology and decipher the scope of therapeutic interventions.
[Blood Cancer Journal]
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TLR4 Signaling in the Development of Colitis-Associated Cancer and Its Possible Interplay with microRNA-155

Considerable attention has been focused on the regulation of TLR4 signaling in the context of colitis-associated tumorigenesis. MicroRNA-155 and TLR4 exhibited a similar dynamic expression change during colitis-associated cancer (CAC) development and shared similar CAC-promoting properties.
[Cell Communication and Signaling]
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GAB1 Alleviates Septic Lung Injury by Inhibiting the TLR4/ NF-κB Pathway

Investigators investigated the involvement of GRB2-associated binding protein 1 (GAB1) in septic lung injury. Lipopolysaccharide induced mouse model and A549 cell model were used to similar the septic lung injury.
[Clinical and Experimental Pharmacology and Physiology]
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SCIMP Is a Spatiotemporal Transmembrane Scaffold for Erk1/2 to Direct Pro-Inflammatory Signaling in TLR-Activated Macrophages

The authors revealed that the immune-specific transmembrane adaptor SCIMP was a direct scaffold for Erk1/2 in TLR pathways, with high-resolution, live-cell imaging revealing that SCIMP guided the spatial and temporal recruitment of Erk2 to membrane ruffles and macropinosomes for pro-inflammatory TLR4 signaling.
[Cell Reports]
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Serum-Derived Exosomes from House Dust Mite-Sensitized Guinea Pigs Contribute to Inflammation in BEAS-2B Cells via the TLR4-NF-κB Pathway

The authors investigated whether serum exosomes played a pro‑inflammatory role in bronchial epithelial cells and explored the underlying molecular mechanisms.
[Molecular Medicine Reports]
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Amygdalin Attenuates Airway Epithelium Apoptosis, Inflammation, and Epithelial-Mesenchymal Transition through Restraining the TLR4/NF-κB Signaling Pathway on LPS-Treated BEAS-2B Bronchial Epithelial Cells

Cough-variant asthma (CVA) is a special type of asthma, solely manifesting with coughing. Investigators suggested that airway inflammation was associated with CVA pathogenesis.
[International Archives of Allergy and Immunology]
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Melatonin as an Immunomodulator in Children with Down Syndrome

Scientists demonstrated that melatonin had several significant effects by reducing CD11b and TLR4 expression, attenuating TLR signaling, genes involved in the inflammasome and had the potential to reduce LPS-induced inflammatory responses.
[Pediatric Research]
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