colorectal cancer

[Cancer Cell International] Expression levels of miR-630 can be used as markers for prediction of cancer course. Moreover, miR-630 can influence response to chemoradiotherapy.

[Gastroenterology] The authors examined the potential utility of patient-derived colorectal cancer organoids in a personalized cancer medicine setting.

[Advanced Science] circREEP3 was found to be upregulated in colorectal cancer tissues. circREEP3 upregulation predicted poor patient survival.

[Signal Transduction and Targeted Therapy] The authors focus on an overview of the recent advances in understanding the molecular basis of colorectal liver metastasis (CRLM) with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.

[Elpiscience Biopharmaceuticals, Inc.] Elpiscience Biopharmaceuticals, Inc. announced that the first patient has been dosed in a Phase I/II clinical study, evaluating the safety, tolerability, preliminary anti-tumor efficacy and pharmacokinetics of ES104, a bispecific antibody that simultaneously blocks the DLL4 and VEGF-A signaling pathways that are critical to angiogenesis and tumor vascularization.

[Biochimica Et Biophysica Acta-Molecular Cell Research] Scientists showed that ANO1 channel protein was upregulated in human colorectal cancer tissue samples and its upregulation was correlated with the TNM staging, histological type, pathological differentiation and poor prognosis.