coronary artery disease

[European Journal of Heart Failure] The authors provide an overview of the available knowledge of body wasting and physical frailty in patients with cardiovascular illness, particularly focusing on patients with heart failure in whom most of the available data has been gathered.

[Signal Transduction and Targeted Therapy] Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) binds to chitin, heparin, and hyaluronic acid, and is regulated by ECM changes, cytokines, growth factors, drugs, and stress. This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis, then posits investigational strategies for targeted therapies.

[RNA Biology] Overexpression of ANRIL transcript NR_003529 increased monocyte adhesion to endothelial cells (ECs) and transendothelial monocyte migration (TEM), whereas knockdown of NR_003529 expression reduced monocyte adhesion to ECs and TEM.