mRNA Vaccine-Induced T Cells Respond Identically to SARS-CoV-2 Variants of Concern but Differ in Longevity and Homing Properties Depending on Prior Infection Status

Researchers conducted a longitudinal study of infection-naïve and COVID-19 convalescent donors before vaccination and after their first and second vaccine doses, using a high-parameter CyTOF analysis to phenotype their SARS-CoV-2-specific T cells.
[eLife]
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Lung Epithelial and Endothelial Damage, Loss of Tissue Repair, Inhibition of Fibrinolysis, and Cellular Senescence in Fatal COVID-19

Lung autopsy samples from 18 patients with fatal COVID-19, with symptom onset-to-death times ranging from 3 to 47 days, and antemortem plasma samples from 6 of these cases were evaluated using deep sequencing of SARS-CoV-2 RNA, multiplex plasma protein measurements, and pulmonary gene expression and imaging analyses.
[Science Translational Medicine]
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Systemic and Mucosal Immune Profiling in Asymptomatic and Symptomatic SARS-CoV-2–Infected Individuals Reveal Unlinked Immune Signatures

The authors evaluated systemic and mucosal immune signatures in asymptomatic SARS-CoV-2–infected versus symptomatic COVID-19 adults compared with RSV-infected adults.
[Science Advances]
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Immunodominant Linear B Cell Epitopes in the Spike and Membrane Proteins of SARS-CoV-2 Identified by Immunoinformatics Prediction and Immunoassay

Three immunodominant linear B cell epitopes in the SARS-CoV-2 spike receptor-binding domain (RBD) were identified by immunoinformatics prediction, and confirmed by ELISA with sera from Macaca fascicularis vaccinated with a SARS-CoV-2 RBD subunit vaccine.
[Scientific Reports]
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Moderna Announces FDA Advisory Committee Unanimously Votes in Support of Emergency Use for a Booster Dose of Moderna’s COVID-19 Vaccine in the US

Moderna, Inc. confirmed that the FDA Vaccines and Related Biological Products Advisory Committee recommended that the FDA grant an Emergency Use Authorization for a booster dose of the Moderna COVID-19 vaccine at the 50 µg dose level for people aged 65 and older; people aged 18 to 64 who are at high risk of severe COVID-19; and people aged 18 to 64 whose exposure to COVID-19 puts them at risk for COVID-19 complications or severe illness.
[Moderna, Inc.]
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Infectious Disease in an Era of Global Change

The authors consider the extent to which recent global changes have increased the risk of infectious disease outbreaks, even as improved sanitation and access to health care have resulted in considerable progress worldwide.
[Nature Reviews Microbiology]
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Characterization of SARS-CoV-2-Specific Humoral Immunity and Its Potential Applications and Therapeutic Prospects

Scientists summarize the characteristics of the humoral immune response after SARS-CoV-2 infection and further emphasize the potential applications and therapeutic prospects of SARS-CoV-2-specific humoral immunity and the critical role of this immunity in vaccine development.
[Cellular & Molecular Immunology]
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Lessons in Self-Defence: Inhibition of Virus Entry by Intrinsic Immunity

Investigators summarize what is known and what remains to be understood about the intrinsic factors that form the first line of defence against virus infection.
[Nature Reviews Immunology]
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Interventional Strategies for Parkinson Disease: Can Neural Precursor Cells Forge a Path Ahead?

The authors discuss the role of PSC-derived neural precursor cells in rat models of MPTP-induced Parkinson’s disease following intranasal injections.
[ACS Chemical Neuroscience]
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Merck and Ridgeback Announce Submission of Emergency Use Authorization Application to the US FDA for Molnupiravir, an Investigational Oral Antiviral Medicine, for the Treatment of Mild-to-Moderate COVID-19 in At Risk Adults

Merck and Ridgeback Biotherapeutics announced that Merck has submitted an Emergency Use Authorization application to the FDA for molnupiravir, an investigational oral antiviral medicine, for the treatment of mild-to-moderate COVID-19 in adults who are at risk for progressing to severe COVID-19 and/or hospitalization.
[Merck (BusinessWire, Inc.)]
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Investigation of Bacterial Infections Among Patients Treated with Umbilical Cord Blood–Derived Products Marketed as Stem Cell Therapies

Researchers examined bacterial infections in 20 patients who received umbilical cord blood–derived products marketed as stem cell treatment.
[JAMA Network Open]
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