COVID-19

[Nature Medicine] The authors investigated induction of antigen-specific antibody, B cell and T cell responses longitudinally in patients with multiple sclerosis on anti-CD20 antibody monotherapy compared with healthy controls after BNT162b2 or mRNA-1273 mRNA vaccination.

[Signal Transduction and Targeted Therapy] Researchers characterized the immune phenotype of B cells from 15 recovered COVID-19 patients, and found that healthy controls and recovered patients had similar B-cell populations before and after BCR stimulation.

[Nature Communications] Researchers report four nanobodies engineered as homotrimers with pmolar affinity for the receptor binding domain of the SARS-CoV-2 spike protein.

[Cell Reports] Investigators screened B cells from COVID-19 donors and identify P5C3, a highly potent and broadly neutralizing monoclonal antibody with picomolar neutralizing activity against all SARS-CoV-2 variants of concern identified to date.

[Cell Reports] Scientists showed that critical COVID-19 was associated with enhanced eosinophil-mediated inflammation when compared to non-critical cases.

[Science] Immunoglobulin G from mRNA-immunized nonhuman primates was passively transferred in a highly pathogenic Syrian hamster SARS-CoV-2 challenge model to determine whether these antibodies were sufficient for protection.