COVID-19

[Cell Metabolism] Researchers describe the detection of SARS-CoV-2 viral antigen in pancreatic beta cells in autopsy samples from individuals with COVID-19.

[Nature Communications] Scientists identified circulating virus-specific T cell responses during acute infection with functional, migratory and apoptotic patterns modulated by viral proteins and associated with clinical outcome.

[Sorrento Therapeutics, Inc.] Sorrento Therapeutics, Inc. announced receipt of clearance from the ANVISA to proceed with a Phase II Pivotal clinical trial of COVI-MSC™, an injectable infusion of MSCs, for the treatment of hospitalized COVID-19 patients suffering from acute respiratory distress syndrome.

[Cancer Discovery] Unexposed patients with hematological malignancies presented with reduced prevalence of pre-existing SARS-CoV-2 cross-reactive CD4+ T cell responses and signs of T cell exhaustion when compared to solid tumor patients and healthy volunteers.

[Prostate Cancer and Prostatic Diseases] Scientists explore the potential mechanisms of SARS-CoV-2 in targeting the prostate gland, leading to exacerbation of benign prostatic hyperplasia (BPH) symptoms and greater risks of BPH complications such as acute urinary retention.

[Communications Biology] Investigators engineered the coat protein of the MS2 bacteriophage and generated nanoparticles displaying multiple copies of the SARS-CoV-2 spike protein.