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dendritic cells

CXCR3 Regulates Stem and Proliferative CD8+ T Cells during Chronic Infection by Promoting Interactions with DCs in Splenic Bridging Channels

[Cell Reports] The authors observed distinct locations for parasite-specific T cell subsets, implying a link between differentiation and anatomical niches in the spleen.

Exosome-Mediated Delivery of Transforming Growth Factor-β Receptor 1 Kinase Inhibitors and Toll-Like Receptor 7/8 Agonists for Combination Therapy of Tumors

[Acta Biomaterialia] Combination therapy with the transforming growth factor-β receptor I kinase inhibitor SD-208 and a toll-like receptor-7/8 agonist resiquimod was examined along with serum-derived exosomes as versatile carriers and may serve as a promising strategy to treat melanoma and prostate cancer.

The Idd2 Locus Confers Prominent Resistance to Autoimmune Diabetes

[Journal of Immunology] Researchers generated a NOD congenic mouse bearing B10 resistance alleles on chromosome 9 in a locus coinciding with part of the insulin-dependent diabetes (Idd) locus and found that NOD.

EBV+ Tumors Exploit Tumor Cell-Intrinsic and -Extrinsic Mechanisms to Produce Regulatory T Cell-Recruiting Chemokines CCL17 and CCL22

[PLoS Pathogens] Both in vitro and in vivo Treg migration was effectively blocked by a novel, small molecule antagonist of CCR4, CCR4-351.

Topical Astilbin Ameliorates Imiquimod-Induced Psoriasis-Like Skin Lesions in SKH-1 Mice via Suppression Dendritic Cell-Th17 Inflammation Axis

[Journal of Cellular and Molecular Medicine] Investigators found that astilbin inhibited R837-induced maturation and activation of bone marrow-derived dendritic cells and decreased the expression of pro-inflammatory cytokines by downregulating myeloid differentiation factor 88.

Single-Cell Analysis Reveals the Immune Characteristics of Myeloid Cells and Memory T Cells in Recovered COVID-19 Patients with Different Severities

[Frontiers in Immunology] According to large-scale single-cell analysis, recovered patients, who had severe symptoms, still exhibited peripheral immune disorders one-two months after symptom onset.

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