To determine if infants of women with depression and anxiety symptoms exhibit epigenetic modifications linked to neurodevelopmental changes, 52 umbilical cord bloods were profiled.
6445218 RIPJBD9B items 1 apa default asc 1
Dean, D. C., Madrid, A., Planalp, E. M., Moody, J. F., Papale, L. A., Knobel, K. M., Wood, E. K., McAdams, R. M., Coe, C. L., Hill Goldsmith, H., Davidson, R. J., Alisch, R. S., & Kling, P. J. (2021). Cord blood DNA methylation modifications in infants are associated with white matter microstructure in the context of prenatal maternal depression and anxiety. Scientific Reports, 11(1), 12181. https://doi.org/10.1038/s41598-021-91642-0 Cite
Scientists described a multicenter effort to test the generality of this pivotal observation, using independent analyses at two laboratories of patient-derived and newly engineered human neurons with heterozygous NRXN1 deletions.
[Proceedings of the National Academy of Sciences of the United States of America]
7753456 IKPIR4UB items 1 apa default asc 1
Pak, C., Danko, T., Mirabella, V. R., Wang, J., Liu, Y., Vangipuram, M., Grieder, S., Zhang, X., Ward, T., Huang, Y.-W. A., Jin, K., Dexheimer, P., Bardes, E., Mitelpunkt, A., Ma, J., McLachlan, M., Moore, J. C., Qu, P., Purmann, C., … Südhof, T. C. (2021). Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived NRXN1-mutant neurons. Proceedings of the National Academy of Sciences, 118(22). https://doi.org/10.1073/pnas.2025598118 Cite
DayTwo, Inc. announced that it has launched a unique methodology for addressing depression in people with diabetes. The new solution, called EATS™ uses psychological techniques to overcome emotional barriers to chronic condition management.
[DayTwo, Inc. (Business Wire, Inc.)]
7753456 nan items 1 apa default asc 1
VistaGen Therapeutics Inc. announced the initiation of its PALISADE Phase III clinical program with the PALISADE-1 Phase III trial, a randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of PH94B for the acute treatment of anxiety in adults with Social Anxiety Disorder.
[VistaGen Therapeutics Inc. (Globenews Wire, Inc.)]
7753456 nan items 1 apa default asc 1
The author shows how understanding differences in the stability of attractor network systems in different brain areas can help to provide a scientific basis for relating some mental disorders to the operation of the underlying brain systems.
6807162 UP8T4WSQ items 1 apa default asc 1
Scientists discuss how the immune responses to dysbiotic microbiota that cross the damaged barrier may be involved in the development of allergic and autoimmune diseases.
[Nature Reviews Immunology]
Scarb1 gene expression was detected in neural stem cells (NSCs), suggesting a possible role of high density lipoproteins (HDLs) in NSC activity.
6807162 RECM6UWB items 1 apa default asc 1
Sulliman, N. C., Ghaddar, B., Gence, L., Patche, J., Rastegar, S., Meilhac, O., & Diotel, N. (2021). HDL biodistribution and brain receptors in zebrafish, using HDLs as vectors for targeting endothelial cells and neural progenitors. Scientific Reports, 11(1), 6439. https://doi.org/10.1038/s41598-021-85183-9 Cite
Investigators summarize the current knowledge on somatostatin (SST) expression and function in the brain. In particular, they describe the physiological roles of SST-positive interneurons in the cortex.
[Experimental and Molecular Medicine]
Scientists used induced pluripotent stem cells to culture neuronal precursor cells and glutamatergic neurons from bipolar disorder patients characterized for lithium responsiveness and matched controls.
6807162 VVVHN6CF items 1 apa default asc 1
Mishra, H. K., Ying, N. M., Luis, A., Wei, H., Nguyen, M., Nakhla, T., Vandenburgh, S., Alda, M., Berrettini, W. H., Brennand, K. J., Calabrese, J. R., Coryell, W. H., Frye, M. A., Gage, F. H., Gershon, E. S., McInnis, M. G., Nievergelt, C. M., Nurnberger, J. I., Shilling, P. D., … McCarthy, M. J. (2021). Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response: preliminary studies. Molecular Psychiatry, 1–12. https://doi.org/10.1038/s41380-021-01048-7 Cite
Researchers nvestigated the short- and long-term effects of electroconvulsive therapy on neuroinflammation and amyloid-beta accumulation.
6807162 JK23T9RZ items 1 apa default asc 1
Svensson, M., Olsson, G., Yang, Y., Bachiller, S., Ekemohn, M., Ekstrand, J., & Deierborg, T. (2021). The effect of electroconvulsive therapy on neuroinflammation, behavior and amyloid plaques in the 5xFAD mouse model of Alzheimer’s disease. Scientific Reports, 11(1), 4910. https://doi.org/10.1038/s41598-021-83998-0 Cite
The authors found that 5-HT6R was highly expressed in human NSCs and activation of the receptor promoted self-renewal of human NSCs, and thus induced the expansion and folding of human cerebral organoids; dysfunction of receptor or inhibition of its constitutive activity resulted in the premature differentiation of NSCs,
[Stem Cell Reports]
6445218 VVZY9DHM items 1 apa default asc 1
Constitutive Activity of Serotonin Receptor 6 Regulates Human Cerebral Organoids Formation and Depression-like Behaviors: Stem Cell Reports. (n.d.). Retrieved January 5, 2021, from https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(20)30463-X Cite