Activation of Proprotein Convertase in the Mouse Habenula Causes Depressive-Like Behaviors through Remodeling of Extracellular Matrix

Scientists found that chronic social defeat stress increased production of pro-inflammatory cytokines in lateral habenula associated with mobilization of monocytes and remodeling of extracellular matrix by increased matrix metalloproteinase activity.
[Neuropsychopharmacology]
Ito, H., Nozaki, K., Sakimura, K., Abe, M., Yamawaki, S., & Aizawa, H. (2020). Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix. Neuropsychopharmacology, 1–14. https://doi.org/10.1038/s41386-020-00843-0 Cite
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The Effects of Microglia‐ and Astrocyte‐Derived Factors on Neurogenesis in Health and Disease

The authors describe how glial cells play a role in adult hippocampal neurogenesis in both health and disease, especially focusing on glia‐derived factors.
[European Journal of Neuroscience]
Araki, T., Ikegaya, Y., & Koyama, R. (2020). The effects of microglia‐ and astrocyte‐derived factors on neurogenesis in health and disease. European Journal of Neuroscience. https://doi.org/10.1111/ejn.14969 Cite
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Development of Muscle Atrophy and Loss of Function in a Gulf-War Illness Model: Underlying Mechanisms

Muscle wasting pathway proteins were upregulated while those that promote growth decreased as did mitochondrial endpoints and muscle ATP levels.
[Scientific Reports]
Ramirez-Sanchez, I., Navarrete-Yañez, V., Garate-Carrillo, A., Loredo, M., Lira-Romero, E., Estrada-Mena, J., Campeau, A., Gonzalez, D., Carrillo-Terrazas, M., Moreno-Ulloa, A., Ceballos, G., & Villarreal, F. (2020). Development of muscle atrophy and loss of function in a Gulf-War illness model: underlying mechanisms. Scientific Reports, 10(1), 14526. https://doi.org/10.1038/s41598-020-71486-w Cite
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N-3 Polyunsaturated Fatty Acids Promote Astrocyte Differentiation and Neurotrophin Production Independent of cAMP in Patient-Derived Neural Stem Cells

iPSC-derived neuronal stem cell lines were generated from individuals with major depressive disorder. Astrocytes differentiated from patient-derived neuronal stem cells were verified by GFAP and cells were treated with eicosapentaenoic acid, docosahexaenoic acid or stearic acid.
[Molecular Psychiatry]
Yu, J.-Z., Wang, J., Sheridan, S. D., Perlis, R. H., & Rasenick, M. M. (2020). N-3 polyunsaturated fatty acids promote astrocyte differentiation and neurotrophin production independent of cAMP in patient-derived neural stem cells. Molecular Psychiatry, 1–11. https://doi.org/10.1038/s41380-020-0786-5 Cite
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