depression

[Molecular Psychiatry] Researchers performed the largest transcriptome-wide association study for postpartum depressionto date using RNA-sequencing in whole blood and deconvoluted cell types.

[Stem Cell Research & Therapy] To investigate neuroprotection effects of adipose stem cell-derived extracellular vesicles in the corticosterone (CORT)-induced cortical neurons, scientists cultured cortical neurons from E15 mice for 7 days, and the cultured cortical neurons were pretreated with different numbers for 30 min followed by administration of 200 μM CORT for 24 hours.

[Nature Reviews Neuroscience] The authors review evidence showing that brain inflammation and activation of cellular stress response mechanisms comprise molecular underpinnings of impaired brain insulin signaling in Alzheimer disease (AD) and integrate impaired insulin signaling with AD pathology.

[Advanced Science] RNA-seq analysis and coimmunoprecipitation assays indicated that HTR1A interacted with TRIM21 and PSMD7 to inhibit the degradation of TβRII through the ubiquitin-proteasome pathway.

[Leonhardt Ventures (Globe Newswire, Inc.)] Leonhardt Ventures LLC announced that it has begun an active research program to combine its patent-pending klotho expression bioelectric stimulation technologies with newly acquired klotho expressing MSC technology.

[Cell Reports] Researchers examined the dynamics of dopamine release and downstream signaling during multiple salient events occurring within tens of seconds and performed real-time tracking and manipulation of cyclic adenosine monophosphate (cAMP) in basal amygdala neurons in vitro and in vivo.