depression

[iScience] Reserachers reported that sustained activation of GluK2 subunit-containing Kainate receptors leads to AMPA receptor endocytosis and induce long-term depression of AMPARs in hippocampal neurons.

[Neuropsychopharmacology] Researchers show that reduced BDNF and GABA also co-occur with attenuated autophagy in human depression.

[Nature Communications] Brain-derived neurotrophic factor (BDNF) is essential for adult synaptic plasticity and its pathway is associated with major depression and posttraumatic stress disorder. Researchers found that stress-enhanced matrix metalloproteinase 9 (MMP9) secretion increased the cleavage of proBDNF to its mature form mBDNF.

[Stemson Therapeutics] Stemson Therapeutics announced the closing of a $15 million Series A financing to advance development of Stemson’s proprietary therapeutic solution to cure hair loss. Stemson’s iPSC based technology is capable of producing the cell types required to initiate hair follicle growth and have been successfully tested in small animal models.

[Acta Pharmacologica Sinica] Researchers showed that sulforaphane confered stress resilience via brain-derived neurotrophic factor upregulation and changes in abnormal dendritic spine morphology in stressed mice, which was accompanied by rectifying the irregular levels of inflammatory cytokines.

[Neurolief, Inc. (BusinessWire, Inc.)] Neurolief, Inc. and NeuroFront, Inc., jointly announced an exclusive licensing agreement for NeuroFront to develop and commercialize Relivion®, non-invasive medical devices for the treatment of migraine and depression, in Greater China and South Korea.