dermal cells

[Cell Reports] Scientists found that Tfap2b and a select set of target genes specified an melanocyte stem cell population at the dorsal root ganglia in zebrafish.

[Biochemical and Biophysical Research Communications] The authors demonstrated that the ablation of vitamin D receptor in keratinocytes greatly exacerbated dermal fibrosis in HOCl-induced scleroderma in mice.

[Theranostics] Researchers reported on non-invasive longitudinal imaging of the wound healing process in transgenic mice overexpressing vascular endothelial growth factor (VEGF) A in keratinocytes by means of large-scale optoacoustic microscopy.

[Nature] The authors identified subsets of dermal fibroblasts that were responsible for driving patterned autoimmune activity, by using a robust mouse model of vitiligo that was based on the activation of endogenous auto-reactive CD8+ T cells that targeted epidermal melanocytes.

[Experimental Dermatology] In the skin, UV-irradiation increases expression of matrix metalloproteinases (MMPs) that causes dysregulation of extracellular matrix homeostasis in dermis, leading to acceleration of skin aging. Researchers reported the role of transglutaminase 2 in mediating the UVB-induced expression of MMP-1.

[Stem Cell Research & Therapy] Scientists summarize on the recent findings concerning the application of MSCs and their derivative exosome to support wound healing and skin regeneration, with special focus on last decade in vivo reports.