dermal cells

[Science] Using a combination of a human PSC–derived cancer model along with zebrafish transgenesis, researchers demonstrated that the transforming ability of BRAFV600E along with additional mutations depended on the intrinsic transcriptional program present in the cell of origin.

[Nature Cell Biology] Researchers used a single-cell enrichment and RNA-sequencing pipeline to study human epidermal melanocytes directly from the skin, capturing transcriptomes across different anatomical sites, developmental age, sexes and multiple skin tones.

[Scientific Reports] Scientists examined if blocking aquaporin 3 could interfere arsenic-induced autophagy in keratinocytes. Expression of aquaporin 3 was increased in arsenical cancers and in arsenic-treated keratinocytes.

[Journal of Investigative Dermatology] The expression of three-hydroxy-3-methylglutaryl coenzyme A synthase 1 in cultured keratinocytes was up-regulated by exogenous Gal-7 and down-regulated in Gal-7 siRNA transfected cells.

[International Journal of Dermatology] Dermal mesenchymal stem cells were cocultured with primary keratinocytes either from psoriatic lesions or from normal subjects using Transwell plate. Expression levels of proteins were analyzed by Western blotting.

[Life Sciences] Scientists investigated the relationship between melanin production and lipofuscin synthesis in normal mouse melanoma cell line B16F1 cells and Tyrosinase gene knockout cells.