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dermal cells

The Landscape of Driver Mutations in Cutaneous Squamous Cell Carcinoma

[NPJ Genomic Medicine] Researchers provided a catalog of driver genes in cutaneous squamous cell carcinoma, offering points of therapeutic intervention and insights into the biology of cutaneous squamous cell carcinoma.

Growth Arrest and DNA Damage-Inducible Proteins (GADD45) in Psoriasis

[Scientific Reports] Researchers analyzed the expression of GADD45a and GADD45b in the skin, dendritic cells and circulating T cells in a cohort of psoriasis patients and their regulation by inflammatory signals.

STAT3-Induced ZBED3-AS1 Promotes the Malignant Phenotypes of Melanoma Cells by Activating PI3K/AKT Signaling Pathway

[RNA Biology] Researchers discovered that ZBED3 antisense RNA 1 (ZBED3-AS1) was overexpressed in melanoma cells compared with human epidermal melanocytes.

GJB5 Association with BRAF Mutation and Survival in Cutaneous Malignant Melanoma

[British Journal of Dermatology] Researchers investigated Connexin 31.1 (GJB5) expression and identified any association with BRAF mutational status, melanoma patient prognosis and MAPK inhibitors treatment.

MicroRNA-378a-3p Is Overexpressed in Psoriasis and Modulates Cell Cycle Arrest in Keratinocytes via Targeting BMP2 Gene

[Scientific Reports] Scientists reported a significant up-regulation of miR-378a-3p in skin biopsies from active psoriatic lesions while it was down-regulated after treatment with methotrexate or narrow-band ultraviolet B phototherapy.

Resveratrol Promotes Skin Wound Healing by Regulating the miR-212/CASP8 Axis

[Laboratory Investigation] Resveratrol (RES) may have potential as a therapy for wound healing, but how and whether RES regulates skin repair remains poorly understood. Human epidermal keratinocyte cells were treated with lipopolysaccharide, and a mouse skin wound-healing model was established.

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