diabetic nephropathy

[Environmental Toxicology] HK-2 cell viability and apoptosis were detected by Cell Counting Kit-8 assay and flow cytometry analysis, respectively. β-amyrin was found to ameliorate kidney injury in diabetic nephropathy mice and suppressed inflammatory response as well as apoptosis of HG-stimulated HK-2 cells.

[EpicentRx, Inc.] EpicentRx, Inc., a clinical-stage biotechnology company at the forefront of oncolytic viruses and small molecules for the treatment of cancer and other inflammatory-driven diseases, today announced that the United States Patent and Trademark Office (USPTO) has issued U.S. Patent No. 10,906,957 entitled "Immunomodulatory Fusion Proteins."

[Journal of Cellular and Molecular Medicine] Scientists investigated the potential link between DOX-induced cell death and pyroptosis in two human breast cancer cell lines and proved that treatment with DOX reduced cell viability in a dose-dependent way and induced pyroptosis morphology.

[Journal of the American Heart Association] Primary podocytes were isolated and subjected to analysis of Wnt signaling and fatty acid metabolism. Conditioned media from primary podocytes was transferred to glomerular endothelial cells.

[Endocrine Journal] Rosiglitazone significantly inhibited high glucose-induced proliferation, oxidative stress, inflammatory responses and extracellular matrix accumulation in mouse mesangial cells.

[Cell Death & Disease] The authors hypothesized that cAMP response element-binding protein (CREB) associated with KMT5A to modulate PTP1B expression, thus contributing to high glucose-mediated glomerular endothelial inflammation.