Rosiglitazone significantly inhibited high glucose-induced proliferation, oxidative stress, inflammatory responses and extracellular matrix accumulation in mouse mesangial cells.
[Endocrine Journal]
1254621 {1254621:PZ5MN9CT} apa 50 1 160778 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-1042f4f6a8d23a5ac7f8f9e783f7850d%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22PZ5MN9CT%22%2C%22library%22%3A%7B%22id%22%3A1254621%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zhao%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EZhao%2C%20D.%2C%20Guo%2C%20J.%2C%20Liu%2C%20L.%2C%20%26amp%3B%20Huang%2C%20Y.%20%282021%29.%20Rosiglitazone%20attenuates%20high%20glucose-induced%20proliferation%2C%20inflammation%2C%20oxidative%20stress%20and%20extracellular%20matrix%20accumulation%20in%20mouse%20mesangial%20cells%20through%20the%20Gm26917%5C%2FmiR-185-5p%20pathway.%20%3Ci%3EEndocrine%20Journal%3C%5C%2Fi%3E%2C%20%3Ci%3Eadvpub%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1507%5C%2Fendocrj.EJ20-0783%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1507%5C%2Fendocrj.EJ20-0783%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D1254621%26amp%3Bitem_key%3DPZ5MN9CT%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Rosiglitazone%20attenuates%20high%20glucose-induced%20proliferation%2C%20inflammation%2C%20oxidative%20stress%20and%20extracellular%20matrix%20accumulation%20in%20mouse%20mesangial%20cells%20through%20the%20Gm26917%5C%2FmiR-185-5p%20pathway%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dongbo%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Junli%22%2C%22lastName%22%3A%22Guo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lingping%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ying%22%2C%22lastName%22%3A%22Huang%22%7D%5D%2C%22abstractNote%22%3A%22Rosiglitazone%20%28RSG%29%20is%20widely%20used%20to%20reduce%20the%20amount%20of%20sugar%20in%20the%20blood%20of%20patients%20with%20diabetes%20mellitus.%20Diabetic%20nephropathy%20is%20the%20most%20common%20microvascular%20complication%20of%20diabetes.%20The%20role%20of%20RSG%20in%20diabetic%20nephropathy%20is%20not%20fully%20understood.%20Diabetic%20nephropathy%20model%20was%20constructed%20in%20high%20glucose%20%28HG%29-treated%20mouse%20mesangial%20cells.%20The%20effects%20of%20RSG%20on%20cell%20viability%20and%20cell%20cycle%20were%20investigated%20using%20cell%20counting%20kit-8%20%28CCK-8%29%20assay%20and%20flow%20cytometry%20assay.%20Oxidative%20stress%20was%20assessed%20according%20to%20ROS%20production%20and%20SOD%20activity%20in%20cells.%20Inflammatory%20responses%20were%20assessed%20according%20to%20the%20releases%20of%20inflammatory%20cytokines.%20Extracellular%20matrix%20%28ECM%29%20accumulation%20was%20determined%20by%20the%20levels%20of%20fibronectin%20and%20collagen%20IV%20using%20western%20blot.%20The%20expression%20of%20Gm26917%20and%20microRNA-185-5p%20%28miR-185-5p%29%20was%20detected%20by%20quantitative%20real-time%20polymerase%20chain%20reaction%20%28qPCR%29.%20The%20interaction%20between%20Gm26917%20and%20miR-185-5p%20was%20validated%20by%20dual-luciferase%20reporter%20assay%2C%20RNA%20immunoprecipitation%20%28RIP%29%20assay%20and%20pull-down%20assay.%20RSG%20significantly%20inhibited%20HG-induced%20proliferation%2C%20oxidative%20stress%2C%20inflammatory%20responses%20and%20ECM%20accumulation%20in%20mouse%20mesangial%20cells.%20The%20expression%20of%20Gm26917%20was%20induced%20by%20HG%20but%20weakened%20by%20RSG.%20Gm26917%20knockdown%20alleviated%20HG-induced%20proliferation%2C%20oxidative%20stress%2C%20inflammatory%20responses%20and%20ECM%20accumulation%20in%20mouse%20mesangial%20cells%2C%20and%20Gm26917%20overexpression%20partly%20abolished%20the%20effects%20of%20RSG.%20Moreover%2C%20miR-185-5p%20was%20a%20target%20of%20Gm26917%2C%20and%20miR-185-5p%20inhibition%20recovered%20proliferation%2C%20oxidative%20stress%2C%20inflammatory%20responses%20and%20ECM%20accumulation%20in%20mouse%20mesangial%20cells%20that%20were%20alleviated%20by%20Gm26917%20knockdown.%20RSG%20ameliorated%20HG-induced%20mouse%20mesangial%20cell%20proliferation%2C%20oxidative%20stress%2C%20inflammation%20and%20ECM%20accumulation%20partially%20by%20governing%20the%20Gm26917%5C%2FmiR-185-5p%20pathway.%22%2C%22date%22%3A%222021%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1507%5C%2Fendocrj.EJ20-0783%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-01T20%3A43%3A18Z%22%7D%7D%5D%7D
Zhao, D., Guo, J., Liu, L., & Huang, Y. (2021). Rosiglitazone attenuates high glucose-induced proliferation, inflammation, oxidative stress and extracellular matrix accumulation in mouse mesangial cells through the Gm26917/miR-185-5p pathway. Endocrine Journal, advpub. https://doi.org/10.1507/endocrj.EJ20-0783 Cite