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ROS production
Immune Regulation News
Phagosomal Signaling of the C-Type Lectin Receptor Dectin-1 Is Terminated by Intramembrane Proteolysis
[Nature Communications] Scientists demonstrated that pathogen recognition by the Dectin-1a isoform resulted in the formation of a stable receptor fragment devoid of the ligand binding domain.
Muscle Cell News
Cardioprotective Effect of Extracellular Vesicles Derived from Ticagrelor-Pretreated Cardiomyocyte on Hyperglycemic Cardiomyocytes through Alleviation of Oxidative and Endoplasmic Reticulum Stress
[Scientific Reports] Scientists investigated the anti-oxidative and cardioprotective effect of extracellular vesicles derived from ticagrelor-pretreated cardiomyocytes under diabetes mellitus conditions.
Muscle Cell News
Involvement of Parkin-Mediated Mitophagy in the Pathogenesis of Chronic Obstructive Pulmonary Disease-Related Sarcopenia
[Journal of Cachexia Sarcopenia and Muscle] The authors examined the involvement of insufficient Parkin-mediated mitophagy, a mitochondrion-selective autophagy, in the mechanisms by which dysfunctional mitochondria accumulated with excessive reactive oxygen species production in the development of chronic obstructive pulmonary disease-related sarcopenia.
Prostate Cell News
5-Aminolevulinic Acid Overcomes Hypoxia-Induced Radiation Resistance by Enhancing Mitochondrial Reactive Oxygen Species Production in Prostate Cancer Cells
[British Journal of Cancer] Researchers investigated whether 5-aminolevulinic acid may increase the sensitisation of prostate cancer cells to radiotherapy through the generation of reactive oxygen species via its metabolite, protoporphyrin IX.
ESC & iPSC News
Analysis of Mitochondrial Dysfunction by Microplate Reader in hiPSC-Derived Neuronal Cell Models of Neurodegenerative Disorders
[Methods in Molecular Biology] The authors describe high-throughput analysis of crucial parameters related to mitochondrial function in hiPSC-derived neurons.
ESC & iPSC News
Genome-Wide Screening in the Haploid System Reveals Slc25a43 as a Target Gene of Oxidative Toxicity
[Cell Death & Disease] Scientists used a forward genetic approach with mouse haploid ESCs to generate high-throughput mutant libraries, from which numerous oxidative stress-targeting genes were screened out.