Induction of Monoamine Oxidase A-Mediated Oxidative Stress and Impairment of NRF2-Antioxidant Defence Response by Polyphenol-Rich Fraction of Bergenia ligulata Sensitizes Prostate Cancer Cells In Vitro and In Vivo

Researchers explored anti-prostate cancer activity in a polyphenol-rich fraction of Bergenia ligulata, a plant used in Indian traditional and folk medicine for its anti-inflammatory and antineoplastic properties.
[Free Radical Biology and Medicine]
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A Small Molecule Inhibitor of Nox2 and Nox4 Improves Contractile Function after Ischemia–Reperfusion in the Mouse Heart

Investigators identified a new compound that inhibited reactive oxygen species production in isolated mouse cardiomyocytes and improved cardiomyocyte contractility and contraction of whole retrogradely perfused hearts after a global ischemia period.
[Scientific Reports]
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UBQLN1 Mediates Sorafenib Resistance through Regulating Mitochondrial Biogenesis and ROS Homeostasis by Targeting PGC1β in Hepatocellular Carcinoma

The authors investigated the roles of ROS in sorafenib resistance, and found suppressed ROS levels and reductive redox states in sorafenib-resistant hepatocellular carcinoma cells.
[Signal Transduction and Targeted Therapy]
Xu, J., Ji, L., Ruan, Y., Wan, Z., Lin, Z., Xia, S., Tao, L., Zheng, J., Cai, L., Wang, Y., Liang, X., & Cai, X. (2021). UBQLN1 mediates sorafenib resistance through regulating mitochondrial biogenesis and ROS homeostasis by targeting PGC1β in hepatocellular carcinoma. Signal Transduction and Targeted Therapy, 6(1), 1–13. https://doi.org/10.1038/s41392-021-00594-4 Cite
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Cephalomannine Inhibits Hypoxia-Induced Cellular Function via the Suppression of APEX1/HIF-1α Interaction in Lung Cancer

Researchers explored the mechanisms underlying cell responses to hypoxia and modulation of apurinic/apyrimidinic endonuclease-1, which regulate hypoxic-induced factor-1α and downstream pathways.
[Cell Death & Disease]
Ullah, A., Leong, S. W., Wang, J., Wu, Q., Ghauri, M. A., Sarwar, A., Su, Q., & Zhang, Y. (2021). Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1α interaction in lung cancer. Cell Death & Disease, 12(5), 1–14. https://doi.org/10.1038/s41419-021-03771-z Cite
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Effect of Hypoxia Factors Gene Silencing on ROS Production and Metabolic Status of A375 Malignant Melanoma Cells

Researchers detected a significantly reduced A375 cell viability, an increase in alanine, inositol, nucleotides, and other metabolites that together define apoptosis.
[Scientific Reports]
Špaková, I., Rabajdová, M., Mičková, H., Graier, W. F., & Mareková, M. (2021). Effect of hypoxia factors gene silencing on ROS production and metabolic status of A375 malignant melanoma cells. Scientific Reports, 11(1), 10325. https://doi.org/10.1038/s41598-021-89792-2 Cite
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Apatinib Suppresses Lung Cancer Stem-Like Cells by Complex Interplay between β-Catenin Signaling and Mitochondrial ROS Accumulation

Investigators demonstrated that apatinib repressed lung CSC-like traits by hindering sphere formation ability, lung CSC-related marker expression and decreasing chemoresistance derived stemness.
[Cell Death Discovery]
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Anti-cancer & Anti-metastasis Properties of Bioorganic-Capped Silver Nanoparticles Fabricated from Juniperus chinensis Extract against Lung Cancer Cells

The authors elucidated the cellular and molecular mechanisms of nanoparticles for anti-proliferative and apoptotic effects on human lung cancer cells and compared them with commercial drug cisplatin.
[Amb Express]
Noorbazargan, H., Amintehrani, S., Dolatabadi, A., Mashayekhi, A., Khayam, N., Moulavi, P., Naghizadeh, M., Mirzaie, A., Mirzaei rad, F., & Kavousi, M. (2021). Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells. AMB Express, 11(1), 61. https://doi.org/10.1186/s13568-021-01216-6 Cite
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Kaempferol Induces ROS-Dependent Apoptosis in Pancreatic Cancer Cells via TGM2-Mediated Akt/mTOR Signaling

Researchers investigated whether kaempferol effectively suppressed pancreatic cancer through upregulation of reactive oxygen species (ROS), and explored the underlying molecular mechanism.
[BMC Cancer]
Wang, F., Wang, L., Qu, C., Chen, L., Geng, Y., Cheng, C., Yu, S., Wang, D., Yang, L., Meng, Z., & Chen, Z. (2021). Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling. BMC Cancer, 21(1), 396. https://doi.org/10.1186/s12885-021-08158-z Cite
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Activation of Matrix Metalloproteinases and FoxO3a in HaCaT Keratinocytes by Radiofrequency Electromagnetic Field Exposure

The authors evaluated the use and trends of active comparator trial designs in dermatology.
[Scientific Reports]
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Rosiglitazone Attenuates High Glucose-Induced Proliferation, Inflammation, Oxidative Stress and Extracellular Matrix Accumulation in Mouse Mesangial Cells through the Gm26917/miR-185-5p Pathway

Rosiglitazone significantly inhibited high glucose-induced proliferation, oxidative stress, inflammatory responses and extracellular matrix accumulation in mouse mesangial cells.
[Endocrine Journal]
Zhao, D., Guo, J., Liu, L., & Huang, Y. (2021). Rosiglitazone attenuates high glucose-induced proliferation, inflammation, oxidative stress and extracellular matrix accumulation in mouse mesangial cells through the Gm26917/miR-185-5p pathway. Endocrine Journal, advpub. https://doi.org/10.1507/endocrj.EJ20-0783 Cite
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Anthracycline-Induced Cardiotoxicity: Molecular Insights Obtained from Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes (hiPSC-CMs)

Scientists describe an assay platform by coupling human-induced pluripotent stem cell–derived cardiomyocytes and impedance measurement, which allowed real-time monitoring of cardiomyocyte cellular index, beating amplitude, and beating rate.
[The AAPS Journal]
Bozza, W. P., Takeda, K., Alterovitz, W.-L., Chou, C.-K., Shen, R.-F., & Zhang, B. (2021). Anthracycline-Induced Cardiotoxicity: Molecular Insights Obtained from Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes (hiPSC-CMs). The AAPS Journal, 23(2), 44. https://doi.org/10.1208/s12248-021-00576-y Cite
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