The authors evaluated the use and trends of active comparator trial designs in dermatology.
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Rosiglitazone significantly inhibited high glucose-induced proliferation, oxidative stress, inflammatory responses and extracellular matrix accumulation in mouse mesangial cells.
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Scientists describe an assay platform by coupling human-induced pluripotent stem cell–derived cardiomyocytes and impedance measurement, which allowed real-time monitoring of cardiomyocyte cellular index, beating amplitude, and beating rate.
[The AAPS Journal]
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Bozza, W. P., Takeda, K., Alterovitz, W.-L., Chou, C.-K., Shen, R.-F., & Zhang, B. (2021). Anthracycline-Induced Cardiotoxicity: Molecular Insights Obtained from Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes (hiPSC-CMs). The AAPS Journal, 23(2), 44. https://doi.org/10.1208/s12248-021-00576-y Cite
Investigators summarize recent studies that discuss and explore the role of SHC1 in the occurrence and progression of liver diseases. They also provide a theoretical basis for future studies.
Scientists investigated the role of succinate and succinate dehydrogenase inhibition in regulation of postnatal cardiomyocyte cell cycle activity and heart regeneration.
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Investigators summarize the functions of reactive oxygen species (ROS) as signaling molecules in order to discuss their roles in cancer development and progression. In addition, the current status of antioxidant use in cancer treatment is examined in order to highlight the importance of the selective use of N-acetylcysteine for specific types of cancer. Finally, the discussion focuses on those types of cancer that rely on ROS for cancer cell survival and the creation of a permissive environment that promotes the progression to malignant cancer.
Scientists showed that albanol B inhibited the proliferation of four human lung cancer cell lines and induced apoptosis, based on the cleavage of caspase-7 and PARP, as well as the downregulation of Bcl-2.
[International Journal of Molecular Sciences]
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Investigators showed that hyperglycemia blunted the hypoxia-dependent induction of miR-210 both in vitro and in human and mouse diabetic wounds.
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Narayanan, S., Eliasson Angelstig, S., Xu, C., Grünler, J., Zhao, A., Zhu, W., Xu Landén, N., Ståhle, M., Zhang, J., Ivan, M., Maltesen, R. G., Botusan, I. R., Rajamand Ekberg, N., Zheng, X., & Catrina, S.-B. (2020). HypoxamiR-210 accelerates wound healing in diabetic mice by improving cellular metabolism. Communications Biology, 3(1), 1–11. https://doi.org/10.1038/s42003-020-01495-y Cite
By using a combination of the bioinformatics and various cellular and molecular assays, scientists demonstrated that SEMG1 and SEMG2 were frequently expressed in lung cancer clinical samples and cancer cell lines of different origins and were negatively associated with the survival rate of cancer patients.
[Cell Death & Disease]
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Efficacy and mechanism of action of marine alkaloid 3,10-dibromofascaplysin were investigated in human prostate cancer cells harboring different levels of drug resistance. Anticancer activity was observed across all cell lines examined without signs of cross-resistance to androgen receptor targeting agents or taxane based chemotherapy.
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Dyshlovoy, S. A., Kaune, M., Hauschild, J., Kriegs, M., Hoffer, K., Busenbender, T., Smirnova, P. A., Zhidkov, M. E., Poverennaya, E. V., Oh-Hohenhorst, S. J., Spirin, P. V., Prassolov, V. S., Tilki, D., Bokemeyer, C., Graefen, M., & von Amsberg, G. (2020). Efficacy and Mechanism of Action of Marine Alkaloid 3,10-Dibromofascaplysin in Drug-Resistant Prostate Cancer Cells. Marine Drugs, 18(12), 609. https://doi.org/10.3390/md18120609 Cite
Scientists investigated the molecular mechanisms by which MSC3D gain the potential for enhanced cell viability. They found that macroautophagy/autophagy was highly induced and ROS production was suppressed in MSC3D as compared to 2D-cultured MSCs.
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