Tag Archives: ROS production

DOCK2 Regulates Antifungal Immunity by Regulating RAC GTPase Activity

Scientists reported that dedicator of cytokinesis 2 (DOCK2) promoted indispensable antifungal innate immune signaling and proinflammatory gene expression in macrophages.
[Cellular & Molecular Immunology]
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Hyperinflammatory Environment Drives Dysfunctional Myeloid Cell Effector Response to Bacterial Challenge in COVID-19

Investigators assessed the influence of COVID-19 plasma hypercytokinemia on the functional responses of myeloid immune cells upon bacterial challenges from acute-phase COVID-19 patients and their corresponding recovery (rec)-phase.
[PLoS Pathogens]
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Curcumin Suppresses Cell Proliferation and Triggers Apoptosis in Vemurafenib-Resistant Melanoma Cells by Downregulating the EGFR Signaling Pathway

Vemurafenib-resistant A375.S2 cells were established, and the functional mechanism of the epidermal growth factor receptor (EGFR), serine–threonine kinase, and the extracellular signal-regulated kinase signaling induced by curcumin was investigated in A375.S2/VR cells in vitro.
[Environmental Toxicology]
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Interaction of SARS-CoV-2 with Cardiomyocytes: Insight into the Underlying Molecular Mechanisms of Cardiac Injury and Pharmacotherapy

The authors provide an overview of the pathways involved with cardiomyocyte in COVID-19 subjects to help promoting pharmacotherapies that can protect against SARS-CoV-2-induced cardiac injuries.
[Biomedicine & Pharmacotherapy]
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Berberine Alleviates Liver Fibrosis through Inducing Ferrous Redox to Activate ROS-Mediated Hepatic Stellate Cells Ferroptosis

Researchers investigated the molecular mechanisms underlying the effect of berberine against liver fibrogenesis in thioacetamide and carbon tetrachloride induced mouse liver fibrosis.
[Cell Death Discovery]
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Berberine Increases the Expression of Cytokines and Proteins Linked to Apoptosis in Human Melanoma Cells

Researchers reported that berberine has important antiproliferative effects and may be alone or in adjunct therapy a promising candidate for melanoma treatment, a cancer with great incidence and high lethality.
[Molecular Biology Reports]
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Bi-Phasic Effect of Gelatin in Myogenesis and Skeletal Muscle Regeneration

Researchers elaborate on a bi-phasic effect of gelatin in skeletal muscle regeneration, mediated by hormetic effects of reactive oxygen species.
[Disease Models & Mechanisms]
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Valproic Acid Disables the Nrf2 Anti-Oxidant Response in Acute Myeloid Leukemia Cells Enhancing Reactive Oxygen Species-Mediated Killing

The authors demonstrated that addition of a commonly used anti-epileptic, valproic acid to low dose bezafibrate and medroxyprogesterone acetate (BaP) enhanced killing of acute myeloid leukemia (AML) cell lines/primary AML cells to levels similar to high dose BaP.
[British Journal of Cancer]
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CPT2 Downregulation Triggers Stemness and Oxaliplatin Resistance in Colorectal Cancer via Activating the ROS/Wnt/β-Catenin-Induced Glycolytic Metabolism

Researchers analyzed carnitine palmitoyltransferase 2 (CPT2) expression in colorectal cancer (CRC) tissues and cells. CPT2 was overexpressed in CRC cell lines, and its effects and molecular mechanism on the proliferation, glycolysis, stemness, and oxaliplatin sensitivity were investigated.
[Experimental Cell Research]
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Mycobacterium tuberculosis Exploits Focal Adhesion Kinase to Induce Necrotic Cell Death and Inhibit Reactive Oxygen Species Production

The authors demonstrated that Mycobacterium tuberculosis infection triggered a time-dependent reduction in the expression of focal adhesion kinase in human macrophages.
[Frontiers in Imm]
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Cofilin1 Oxidation Links Oxidative Distress to Mitochondrial Demise and Neuronal Cell Death

Investigators presented the role of the actin-regulating protein cofilin1 in regulating mitochondrial pathways in oxidative neuronal death.
[Cell Death & Disease]
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