Small Molecule Compound M12 Reduces Vascular Permeability in Obese Mice via Blocking Endothelial TRPV4–Nox2 Interaction

The authors showed that interrupting TRPV4–Nox2 coupling by TRPV4 knockout, or by treatment with a specific Nox2 inhibitor Nox2 dstat or a specific TRPV4 inhibitor HC067046 significantly attenuated obesity-induced ROS overproduction in aortic endothelial cells, and reversed the abnormal endothelial cytoskeletal structure.
[Acta Pharmacologica Sinica]
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Mechanism of Neutrophil Extracellular Traps Generation and Their Role in Trophoblast Apoptosis in Gestational Diabetes Mellitus

The authors revealed the mechanism of neutrophil extracellular traps generation and their role in trophoblast apoptosis in gestational diabetes mellitus.
[Cellular Signalling]
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Protective Effect of Xiao-Xu-Ming Decoction-Mediated Inhibition of ROS/NLRP3 Axis on Lipopolysaccharide-Induced Acute Lung Injury In Vitro and In Vivo

As a traditional Chinese medicine prescription, Xiao-Xu-Ming decoction (XXMD) could reduce the incidence of lung infection of patients with cerebral infarction. In vitro, human pulmonary alveolar epithelial cells were treated with XXMD and were followed by lipopolysaccharide treatment.
[Evidence-Based Complementary and Alternative Medicine]
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Doxorubicin Suppresses Chondrocyte Differentiation by Stimulating ROS Production

Scientists explored the specific mechanism of doxorubicin in osteoarthritis (OA). A mouse OA model was established by destabilizing the medial meniscus, and the role of DOX was determined by intraperitoneally injecting five or ten mg/kg DOX.
[European Journal of Pharmaceutical Sciences]
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Three-Dimensional Covalent Organic Frameworks with Cross-Linked Pores for Efficient Cancer Immunotherapy

Mechanism studies revealed that after linking these immunogenic cell death inert monomers into the covalent organic frameworks (COFs) backbone, the optical properties of these COFs could be systematically tuned to achieve excellent reactive oxygen species production performance.
[Nano Letters]
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SPRY4 Acts as an Indicator of Osteoarthritis Severity and Regulates Chondrocyte Hypertrophy and ECM Protease Expression

Using SPRY4 gene delivery into healthy and degenerated chondrocytes, investigators elucidated the role of SPRY4 in preventing chondrocyte hypertrophy. In addition to using the human cartilage tissues with the destabilization of the model in Sprague-Dawley rats, the role of SPRY4 in cartilage tissues and chondrocytes was explored through their molecular and histological analysis.
[NPJ Regenerative Medicine]
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Bioglass Promotes Wound Healing by Inhibiting Endothelial Cell Pyroptosis through Regulation of the Connexin 43/Reactive Oxygen Species (ROS) Signaling Pathway

Researchers investigated the possible effect of bioactive glass (BG) on pyroptosis in wound healing both in vivo and in vitro and showed that BG could accelerate wound closure, granulation formation, collagen deposition, and angiogenesis.
[Laboratory Investigation]
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Effect of Endothelial Progenitor Cell-Derived Extracellular Vesicles on Endothelial Cell Ferroptosis and Atherosclerotic Vascular Endothelial Injury

Researchers focused on the role of endothelial progenitor cell-secreted extracellular vesicles in atherosclerosis.
[Cell Death Discovery]
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All-Purpose Nanostrategy Based on Dose Deposition Enhancement, Cell Cycle Arrest, DNA Damage, and ROS Production as Prostate Cancer Radiosensitizer for Potential Clinical Translation

Scientists proposed an ‘all-purpose’ nanostrategy based on dose deposition enhancement, cell cycle arrest, and ROS production as prostate cancer radiosensitizer for potential clinical translation.
[Nanoscale]
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Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes

Scientists demonstrated that overwhelming mitochondrial fragmentation in mutant hematopoietic stem cells and progenitors triggered ineffective hematopoiesis in myelodysplastic syndromes.
[Cancer Discovery]
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Mitochondrial Fatty Acid Utilization Increases Chromatin Oxidative Stress in Cardiomyocytes

Scientists generated reactive oxygen species (ROS)-sensitive fluorescent sensors targeted to different subnuclear compartments in neonatal rat ventricular cardiomyocytes, which allowed them to determine the spatial localization of ROS in cardiomyocyte nuclei upon manipulation of mitochondrial respiration.
[Proceedings of the National Academy of Sciences of the United States of America]
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