Activation of Matrix Metalloproteinases and FoxO3a in HaCaT Keratinocytes by Radiofrequency Electromagnetic Field Exposure

The authors evaluated the use and trends of active comparator trial designs in dermatology.
[Scientific Reports]
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Rosiglitazone Attenuates High Glucose-Induced Proliferation, Inflammation, Oxidative Stress and Extracellular Matrix Accumulation in Mouse Mesangial Cells through the Gm26917/miR-185-5p Pathway

Rosiglitazone significantly inhibited high glucose-induced proliferation, oxidative stress, inflammatory responses and extracellular matrix accumulation in mouse mesangial cells.
[Endocrine Journal]
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Anthracycline-Induced Cardiotoxicity: Molecular Insights Obtained from Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes (hiPSC-CMs)

Scientists describe an assay platform by coupling human-induced pluripotent stem cell–derived cardiomyocytes and impedance measurement, which allowed real-time monitoring of cardiomyocyte cellular index, beating amplitude, and beating rate.
[The AAPS Journal]
Bozza, W. P., Takeda, K., Alterovitz, W.-L., Chou, C.-K., Shen, R.-F., & Zhang, B. (2021). Anthracycline-Induced Cardiotoxicity: Molecular Insights Obtained from Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes (hiPSC-CMs). The AAPS Journal, 23(2), 44. https://doi.org/10.1208/s12248-021-00576-y Cite
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Src Homolog and Collagen Homolog1 Isoforms in Acute and Chronic Liver Injuries

Investigators summarize recent studies that discuss and explore the role of SHC1 in the occurrence and progression of liver diseases. They also provide a theoretical basis for future studies.
[Life Sciences]
Ma, H., Wang, C., Liu, X., Zhan, M., Wei, W., & Niu, J. (2021). Src homolog and collagen homolog1 isoforms in acute and chronic liver injuries. Life Sciences, 273, 119302. https://doi.org/10.1016/j.lfs.2021.119302 Cite
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Malonate Promotes Adult Cardiomyocyte Proliferation and Heart Regeneration

Scientists investigated the role of succinate and succinate dehydrogenase inhibition in regulation of postnatal cardiomyocyte cell cycle activity and heart regeneration.
[Circulation]
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Possible Beneficial Effects of N-Acetylcysteine for Treatment of Triple-Negative Breast Cancer

Investigators summarize the functions of reactive oxygen species (ROS) as signaling molecules in order to discuss their roles in cancer development and progression. In addition, the current status of antioxidant use in cancer treatment is examined in order to highlight the importance of the selective use of N-acetylcysteine for specific types of cancer. Finally, the discussion focuses on those types of cancer that rely on ROS for cancer cell survival and the creation of a permissive environment that promotes the progression to malignant cancer.
[Antioxidants]
Kwon, Y. (2021). Possible Beneficial Effects of N-Acetylcysteine for Treatment of Triple-Negative Breast Cancer. Antioxidants, 10(2), 169. https://doi.org/10.3390/antiox10020169 Cite
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Albanol B from Mulberries Exerts Anti-Cancer Effect through Mitochondria ROS Production in Lung Cancer Cells and Suppresses In Vivo Tumor Growth

Scientists showed that albanol B inhibited the proliferation of four human lung cancer cell lines and induced apoptosis, based on the cleavage of caspase-7 and PARP, as well as the downregulation of Bcl-2.
[International Journal of Molecular Sciences]
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HypoxamiR-210 Accelerates Wound Healing in Diabetic Mice by Improving Cellular Metabolism

Investigators showed that hyperglycemia blunted the hypoxia-dependent induction of miR-210 both in vitro and in human and mouse diabetic wounds.
[Communications Biology]
Narayanan, S., Eliasson Angelstig, S., Xu, C., Grünler, J., Zhao, A., Zhu, W., Xu Landén, N., Ståhle, M., Zhang, J., Ivan, M., Maltesen, R. G., Botusan, I. R., Rajamand Ekberg, N., Zheng, X., & Catrina, S.-B. (2020). HypoxamiR-210 accelerates wound healing in diabetic mice by improving cellular metabolism. Communications Biology, 3(1), 1–11. https://doi.org/10.1038/s42003-020-01495-y Cite
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SEMG1/2 Augment Energy Metabolism of Tumor Cells

By using a combination of the bioinformatics and various cellular and molecular assays, scientists demonstrated that SEMG1 and SEMG2 were frequently expressed in lung cancer clinical samples and cancer cell lines of different origins and were negatively associated with the survival rate of cancer patients.
[Cell Death & Disease]
Shuvalov, O., Kizenko, A., Petukhov, A., Fedorova, O., Daks, A., Bottrill, A., Snezhkina, A. V., Kudryavtseva, A. V., & Barlev, N. (2020). SEMG1/2 augment energy metabolism of tumor cells. Cell Death & Disease, 11(12), 1–14. https://doi.org/10.1038/s41419-020-03251-w Cite
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Efficacy and Mechanism of Action of Marine Alkaloid 3,10-Dibromofascaplysin in Drug-Resistant Prostate Cancer Cells

Efficacy and mechanism of action of marine alkaloid 3,10-dibromofascaplysin were investigated in human prostate cancer cells harboring different levels of drug resistance. Anticancer activity was observed across all cell lines examined without signs of cross-resistance to androgen receptor targeting agents or taxane based chemotherapy.
[Marine Drugs]
Dyshlovoy, S. A., Kaune, M., Hauschild, J., Kriegs, M., Hoffer, K., Busenbender, T., Smirnova, P. A., Zhidkov, M. E., Poverennaya, E. V., Oh-Hohenhorst, S. J., Spirin, P. V., Prassolov, V. S., Tilki, D., Bokemeyer, C., Graefen, M., & von Amsberg, G. (2020). Efficacy and Mechanism of Action of Marine Alkaloid 3,10-Dibromofascaplysin in Drug-Resistant Prostate Cancer Cells. Marine Drugs, 18(12), 609. https://doi.org/10.3390/md18120609 Cite
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Enhanced Viability and Function of Mesenchymal Stromal Cell Spheroids Is Mediated via Autophagy Induction

Scientists investigated the molecular mechanisms by which MSC3D gain the potential for enhanced cell viability. They found that macroautophagy/autophagy was highly induced and ROS production was suppressed in MSC3D as compared to 2D-cultured MSCs.
[Autophagy]
Regmi, S., Raut, P. K., Pathak, S., Shrestha, P., Park, P.-H., & Jeong, J.-H. (2020). Enhanced viability and function of mesenchymal stromal cell spheroids is mediated via autophagy induction. Autophagy, 0(ja), null. https://doi.org/10.1080/15548627.2020.1850608 Cite
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