ROS production

[Nature Communications] Scientists demonstrated that pathogen recognition by the Dectin-1a isoform resulted in the formation of a stable receptor fragment devoid of the ligand binding domain.

[Scientific Reports] Scientists investigated the anti-oxidative and cardioprotective effect of extracellular vesicles derived from ticagrelor-pretreated cardiomyocytes under diabetes mellitus conditions.

[Journal of Cachexia Sarcopenia and Muscle] The authors examined the involvement of insufficient Parkin-mediated mitophagy, a mitochondrion-selective autophagy, in the mechanisms by which dysfunctional mitochondria accumulated with excessive reactive oxygen species production in the development of chronic obstructive pulmonary disease-related sarcopenia.

[British Journal of Cancer] Researchers investigated whether 5-aminolevulinic acid may increase the sensitisation of prostate cancer cells to radiotherapy through the generation of reactive oxygen species via its metabolite, protoporphyrin IX.

[Cell Death & Disease] Irisin effectively inhibited β-GP-induced calcium deposition in VSMCs in vitro and in mice aortic rings ex vivo. Overexpression of Nlrp3 attenuated the suppressive effect of Irisin on VSMC calcification.

[Cell Death & Disease] Scientists used a forward genetic approach with mouse haploid ESCs to generate high-throughput mutant libraries, from which numerous oxidative stress-targeting genes were screened out.