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ROS production

Phagosomal Signaling of the C-Type Lectin Receptor Dectin-1 Is Terminated by Intramembrane Proteolysis

[Nature Communications] Scientists demonstrated that pathogen recognition by the Dectin-1a isoform resulted in the formation of a stable receptor fragment devoid of the ligand binding domain.

Cardioprotective Effect of Extracellular Vesicles Derived from Ticagrelor-Pretreated Cardiomyocyte on Hyperglycemic Cardiomyocytes through Alleviation of Oxidative and Endoplasmic Reticulum Stress

[Scientific Reports] Scientists investigated the anti-oxidative and cardioprotective effect of extracellular vesicles derived from ticagrelor-pretreated cardiomyocytes under diabetes mellitus conditions.

Involvement of Parkin-Mediated Mitophagy in the Pathogenesis of Chronic Obstructive Pulmonary Disease-Related Sarcopenia

[Journal of Cachexia Sarcopenia and Muscle] The authors examined the involvement of insufficient Parkin-mediated mitophagy, a mitochondrion-selective autophagy, in the mechanisms by which dysfunctional mitochondria accumulated with excessive reactive oxygen species production in the development of chronic obstructive pulmonary disease-related sarcopenia.

5-Aminolevulinic Acid Overcomes Hypoxia-Induced Radiation Resistance by Enhancing Mitochondrial Reactive Oxygen Species Production in Prostate Cancer Cells

[British Journal of Cancer] Researchers investigated whether 5-aminolevulinic acid may increase the sensitisation of prostate cancer cells to radiotherapy through the generation of reactive oxygen species via its metabolite, protoporphyrin IX.

Irisin Protects against Vascular Calcification by Activating Autophagy and Inhibiting NLRP3-Mediated Vascular Smooth Muscle Cell Pyroptosis in Chronic Kidney Disease

[Cell Death & Disease] Irisin effectively inhibited β-GP-induced calcium deposition in VSMCs in vitro and in mice aortic rings ex vivo. Overexpression of Nlrp3 attenuated the suppressive effect of Irisin on VSMC calcification.

Genome-Wide Screening in the Haploid System Reveals Slc25a43 as a Target Gene of Oxidative Toxicity

[Cell Death & Disease] Scientists used a forward genetic approach with mouse haploid ESCs to generate high-throughput mutant libraries, from which numerous oxidative stress-targeting genes were screened out.