NSAIDs-Dependent Adaption of the Mitochondria-Proteasome System in Immortalized Human Cardiomyocytes

Researchers evaluated the effects of Ketoprofen in comparison with Diclofenac in immortalized human cardiomyocytes. The results obtained highlight the dose-dependent cardiotoxicity of Diclofenac compared to Ketoprofen.
[Scientific Reports]
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Importance of Cholesterol-Rich Microdomains in the Regulation of Nox Isoforms and Redox Signaling in Human Vascular Smooth Muscle Cells

Scientists examined the sub-cellular compartmentalization of Nox isoforms in lipid rafts/caveolae and assessed the role of these microdomains in vascular smooth muscle cell reactive oxygen species production and pro-contractile and growth signaling.
[Scientific Reports]
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Rejuvenation of Mesenchymal Stem Cells by Extracellular Vesicles Inhibits the Elevation of Reactive Oxygen Species

The authors examined the roles of aging-associated reactive oxygen species in the function and rejuvenation of elderly MSCs by infant extracellular vesicles.
[Scientific Reports]
Khanh, V. C., Yamashita, T., Ohneda, K., Tokunaga, C., Kato, H., Osaka, M., Hiramatsu, Y., & Ohneda, O. (2020). Rejuvenation of mesenchymal stem cells by extracellular vesicles inhibits the elevation of reactive oxygen species. Scientific Reports, 10(1), 17315. https://doi.org/10.1038/s41598-020-74444-8 Cite
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Increased Expression of Glutamine Transporter SNAT2/SLC38A2 Promotes Glutamine Dependence and Oxidative Stress Resistance, and Is Associated with Worse Prognosis in TNBC

The effect of SLC38A2 knockdown in glutamine -sensitive cell lines was analysed.
[British Journal of Cancer]
Morotti, M., Zois, C. E., El-Ansari, R., Craze, M. L., Rakha, E. A., Fan, S.-J., Valli, A., Haider, S., Goberdhan, D. C. I., Green, A. R., & Harris, A. L. (2020). Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer. British Journal of Cancer, 1–12. https://doi.org/10.1038/s41416-020-01113-y Cite
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BAFF-Driven NLRP3 Inflammasome Activation in B Cell

Scientists report BAFF engagement to BAFF receptor elicited both priming and activating signals for NLRP3 inflammasomes in primary B cells and B lymphoma cell lines.
[Cell Death & Disease]
Lim, K.-H., Chen, L.-C., Hsu, K., Chang, C.-C., Chang, C.-Y., Kao, C.-W., Chang, Y.-F., Chang, M.-C., & Chen, C. G. (2020). BAFF-driven NLRP3 inflammasome activation in B cells. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-03035-2 Cite
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Hydrogen Peroxide Causes Cell Death via Increased Transcription of HOXB13 in Human Lung Epithelial A549 Cells

Scientists studied the role of homeobox protein B13 (HOXB13) in cytotoxicity caused by hydrogen peroxide in human lung epithelial A549 cells. The knockdown of HOXB13 reduced hydrogen peroxide-induced cytotoxicity; however, this phenomenon was largely absent in the presence of antioxidants.
[Toxics]
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PM014 Attenuates Radiation-Induced Pulmonary Fibrosis via Regulating NF-kB and TGF-b1/NOX4 Pathways

Scientists investigated the radioprotective effects and the underlying mechanism of the standardized herbal extract PM014 on radiation-induced lung fibrosis.
[Scientific Reports]
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CB11, a Novel Purine-Based PPARɣ Ligand, Overcomes Radio-Resistance by Regulating ATM Signaling and EMT in Human Non-Small-Cell Lung Cancer Cells

CB11 caused cell death via reactive oxygen species-mediated ATM-p53-GADD45α signaling in human non-small-cell lung cancer cells, and diphenyleneiodonium, an NADPH oxidase inhibitor, decreases cell death by inhibiting CB11-mediated ATM signaling.
[British Journal of Cancer]
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Oxidative Stress-Mediated Mitochondrial Dysfunction Facilitates Mesenchymal Stem Cell Senescence in Ankylosing Spondylitis

Researchers found that ankylosing spondylitis (AS) serum facilitated senescence of MSCs in vitro, and articular tissues from AS patients exhibited higher expression levels of the cell cycle arrest-related proteins p53, p21 and p16.
[Cell Death & Disease]
Ye, G., Xie, Z., Zeng, H., Wang, P., Li, J., Zheng, G., Wang, S., Cao, Q., Li, M., Liu, W., Cen, S., Li, Z., Wu, Y., Ye, Z., & Shen, H. (2020). Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-02993-x Cite
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SIRT1/SIRT3 Modulates Redox Homeostasis during Ischemia/Reperfusion in the Aging Heart

The authors discuss the cellular and functional alterations upon ischemia/reperfusion (I/R) especially in aging hearts. They propose that mitochondria are the primary source of reactive oxygen species that contribute to I/R injury in aged hearts. Then, they highlight the cardiomyocyte protection of the age-related proteins Sirtuin1 and Sirtuin1 in response to I/R injury, and discuss their modulation of cardiac metabolism and the inflammatory reaction that is involved in ROS formation.
[Antioxidants]
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Anti-Breast Cancer Activities of Ketoprofen-RGD Conjugate by Targeting Breast Cancer Stem-Like Cells and Parental Cells

Researchers explored the effects of a novel ketoprofen-RGD compound on the suppression of breast cancer stem-like cells and their parental cells.
[Anti-Cancer Agents in Medicinal Chemistry]
Noori, S., Rajabi*, S., Tavirani, M. R., & Zarghi, B. S. and A. (1969, December 31). Anti-Breast Cancer Activities of Ketoprofen-RGD Conjugate by Targeting Breast Cancer Stem-Like Cells and Parental Cells. Anti-Cancer Agents in Medicinal Chemistry. https://www.eurekaselect.com/185695/article Cite
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