Researchers explored anti-prostate cancer activity in a polyphenol-rich fraction of Bergenia ligulata, a plant used in Indian traditional and folk medicine for its anti-inflammatory and antineoplastic properties.
[Free Radical Biology and Medicine]
6445212 GUJ8YJ7C items 1 apa default asc 1
Investigators identified a new compound that inhibited reactive oxygen species production in isolated mouse cardiomyocytes and improved cardiomyocyte contractility and contraction of whole retrogradely perfused hearts after a global ischemia period.
6445212 JA3SRYSJ items 1 apa default asc 1
The authors investigated the roles of ROS in sorafenib resistance, and found suppressed ROS levels and reductive redox states in sorafenib-resistant hepatocellular carcinoma cells.
[Signal Transduction and Targeted Therapy]
7753456 8HC8WGJD items 1 apa default asc 1
Xu, J., Ji, L., Ruan, Y., Wan, Z., Lin, Z., Xia, S., Tao, L., Zheng, J., Cai, L., Wang, Y., Liang, X., & Cai, X. (2021). UBQLN1 mediates sorafenib resistance through regulating mitochondrial biogenesis and ROS homeostasis by targeting PGC1β in hepatocellular carcinoma. Signal Transduction and Targeted Therapy, 6(1), 1–13. https://doi.org/10.1038/s41392-021-00594-4 Cite
Researchers explored the mechanisms underlying cell responses to hypoxia and modulation of apurinic/apyrimidinic endonuclease-1, which regulate hypoxic-induced factor-1α and downstream pathways.
[Cell Death & Disease]
7753456 23QH88EM items 1 apa default asc 1
Ullah, A., Leong, S. W., Wang, J., Wu, Q., Ghauri, M. A., Sarwar, A., Su, Q., & Zhang, Y. (2021). Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1α interaction in lung cancer. Cell Death & Disease, 12(5), 1–14. https://doi.org/10.1038/s41419-021-03771-z Cite
Researchers detected a significantly reduced A375 cell viability, an increase in alanine, inositol, nucleotides, and other metabolites that together define apoptosis.
7753456 RKU9VMCS items 1 apa default asc 1
Investigators demonstrated that apatinib repressed lung CSC-like traits by hindering sphere formation ability, lung CSC-related marker expression and decreasing chemoresistance derived stemness.
[Cell Death Discovery]
6445212 SQHWTZAR items 1 apa default asc 1
The authors elucidated the cellular and molecular mechanisms of nanoparticles for anti-proliferative and apoptotic effects on human lung cancer cells and compared them with commercial drug cisplatin.
7753456 FWZIQF9M items 1 apa default asc 1
Noorbazargan, H., Amintehrani, S., Dolatabadi, A., Mashayekhi, A., Khayam, N., Moulavi, P., Naghizadeh, M., Mirzaie, A., Mirzaei rad, F., & Kavousi, M. (2021). Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells. AMB Express, 11(1), 61. https://doi.org/10.1186/s13568-021-01216-6 Cite
Researchers investigated whether kaempferol effectively suppressed pancreatic cancer through upregulation of reactive oxygen species (ROS), and explored the underlying molecular mechanism.
6807162 IEDHCSW8 items 1 apa default asc 1
The authors evaluated the use and trends of active comparator trial designs in dermatology.
6445212 ZF33FCDI items 1 apa default asc 1
Rosiglitazone significantly inhibited high glucose-induced proliferation, oxidative stress, inflammatory responses and extracellular matrix accumulation in mouse mesangial cells.
1254621 PZ5MN9CT items 1 apa default asc 1
Zhao, D., Guo, J., Liu, L., & Huang, Y. (2021). Rosiglitazone attenuates high glucose-induced proliferation, inflammation, oxidative stress and extracellular matrix accumulation in mouse mesangial cells through the Gm26917/miR-185-5p pathway. Endocrine Journal, advpub. https://doi.org/10.1507/endocrj.EJ20-0783 Cite
Scientists describe an assay platform by coupling human-induced pluripotent stem cell–derived cardiomyocytes and impedance measurement, which allowed real-time monitoring of cardiomyocyte cellular index, beating amplitude, and beating rate.
[The AAPS Journal]
6445218 RXED5BER items 1 apa default asc 1
Bozza, W. P., Takeda, K., Alterovitz, W.-L., Chou, C.-K., Shen, R.-F., & Zhang, B. (2021). Anthracycline-Induced Cardiotoxicity: Molecular Insights Obtained from Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes (hiPSC-CMs). The AAPS Journal, 23(2), 44. https://doi.org/10.1208/s12248-021-00576-y Cite