Selenoprotein P Inhibits Cell Proliferation and ROX Production in HCC Cells

Researchers observed the expression of selenoprotein P in livers from patients with hepatocellular carcinoma (HCC) and explored its effect on HCC cells.
[PLoS One]
Wang, J., Shen, P., Liao, S., Duan, L., Zhu, D., Chen, J., Chen, L., Sun, X., & Duan, Y. (2020). Selenoprotein P inhibits cell proliferation and ROX production in HCC cells. PLOS ONE, 15(7), e0236491. https://doi.org/10.1371/journal.pone.0236491 Cite
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Ciclopirox Activates PERK-Dependent Endoplasmic Reticulum Stress to Drive Cell Death in Colorectal Cancer

Scientists report that ciclopirox exhibited strong antitumorigenic properties in colorectal cancer by inducing cell cycle arrest, repressing cell migration, and invasion by affecting N-cadherin, Snail, E-cadherin, MMP-2, and MMP-9 expression. Disruption of cellular bioenergetics contributed to ciclopirox-associated inhibition of cell growth, migration, and invasion.
[Cell Death & Disease]
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DDX5-Targeting Fully Human Monoclonal Autoantibody Inhibits Proliferation and Promotes Differentiation of Acute Promyelocytic Leukemia Cells by Increasing ROS Production

2F5 was confirmed to induce G0/G1 phase arrest in acute promyelocytic leukemia (APL) cells, and promoted APL cell differentiation combined with decreased DDX5 expression and increased reactive oxygen species production. Knockdown of DDX5 by siRNA also inhibited proliferation, promoted cell differentiation and enhanced ROS production in APL cells.
[Cell Death & Disease]
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Cancer Stem Cell-Targeted Bio-Imaging and Chemotherapeutic Perspective

Researchers address the current knowledge regarding cancer stem cells (CSCs) with a focus on designing chemotherapeutic and bio-imaging reagents that target CSCs.
[Chemical Society Reviews]
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A Novel Mitochondrial Targeted Hybrid Peptide Modified HPMA Copolymers for Breast Cancer Metastasis Suppression

Researchers designed a mitochondrial targeted drug delivery system based on N-(2-hydroxypropyl) methacrylamide copolymers to simultaneously inhibit breast cancer progression and metastasis.
[Journal of Controlled Release]
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Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3

Investigators demonstrated that the artificial sweeteners sucralose, aspartame, and saccharin exerted a range of negative effects on the intestinal epithelium through the sweet taste receptor T1R3.
[Nutrients]
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MicroRNA and ROS Crosstalk in Cardiac and Pulmonary Diseases

The authors focus on the complex crosstalk between miRNAs and ROS in diseases of the cardiac and pulmonary compartments.
[International Journal of Molecular Sciences]
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The Melatonin Receptor Antagonist Luzindole Induces the Activation of Cellular Stress Responses and Decreases Viability of Rat Pancreatic Stellate Cells

Investigators examined the effects of luzindole, a melatonin receptorā€antagonist, on cultured pancreatic stellate cells.
[Journal of Applied Toxicology]
Estaras, M., Marchena, A. M., Fernandez‐Bermejo, M., Mateos, J. M., Vara, D., Roncero, V., Salido, G. M., & Gonzalez, A. (n.d.). The melatonin receptor antagonist luzindole induces the activation of cellular stress responses and decreases viability of rat pancreatic stellate cells. Journal of Applied Toxicology, n/a(n/a). https://doi.org/10.1002/jat.4018 Cite
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Glutathione S-Transferase pi-1 Knockdown Reduces Pancreatic Ductal Adenocarcinoma Growth by Activating Oxidative Stress Response Pathways

Researchers showed glutathione S-transferase pi-1 knockdown reduced pancreatic ductal adenocarcinoma (PDAC) cell growth, prolonged the G0/G1 phase, and elevated reactive oxygen species in PDAC cells.
[Cancers]
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