miR-541-3p Enhances the Radiosensitivity of Prostate Cancer Cells by Inhibiting HSP27 Expression and Downregulating β-Catenin

Scientists investigated the function and mechanism underlying how miR-541-3p modulates the radiosensitivity of prostate cancer cells by regulating HSP27.
[Cell Death Discovery]
He, Z., Shen, F., Qi, P., Zhai, Z., & Wang, Z. (2021). miR-541-3p enhances the radiosensitivity of prostate cancer cells by inhibiting HSP27 expression and downregulating β-catenin. Cell Death Discovery, 7(1), 1–13. https://doi.org/10.1038/s41420-020-00387-8 Cite
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Long Noncoding RNA SNHG1 Promotes Human Prostate Cancer Progression by Sponging miR-383-5p

Investigators found the level of small nucleolar RNA host gene 1 (SNHG1) was significantly upregulated in prostate cancer tissues and cells. Knockdown of SNHG1 significantly suppressed proliferation, migration and invasion and promoted cell apoptosis in prostate cancer cells.
[Anti-Cancer Drugs]
Huang, G., Guo, X., & Yang, H. (2021). Long noncoding RNA SNHG1 promotes human prostate cancer progression by sponging miR-383-5p. Anti-Cancer Drugs, Publish Ahead of Print. https://doi.org/10.1097/CAD.0000000000000916 Cite
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LINC01152 Upregulates MAML2 Expression to Modulate the Progression of Glioblastoma Multiforme via Notch Signaling Pathway

Investigators explored the function and mechanism of LINC01152 in glioblastoma multiforme (GBM). Then qRT-PCR analysis was implemented to search the expression of RNAs in GBM tissues and cells.
[Cell Death & Disease]
Wu, J., Wang, N., Yang, Y., Jiang, G., Mu, Q., Zhan, H., & Li, F. (2021). LINC01152 upregulates MAML2 expression to modulate the progression of glioblastoma multiforme via Notch signaling pathway. Cell Death & Disease, 12(1), 1–14. https://doi.org/10.1038/s41419-020-03163-9 Cite
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LncRNA GAS6-AS2 Promotes Non-Small-Cell Lung Cancer Cell Proliferation via Regulating miR-144-3p/ MAPK6 Axis

GAS6-AS2 was identified, and its roles as well as mechanisms in regulating proliferation of non-small cell lung cancer cells were investigated.
[Cell Cycle]
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Hsa_circ_0005273 Facilitates Breast Cancer Tumorigenesis by Regulating YAP1-Hippo Signaling Pathway

The effect of knocking down hsa_circ_0005273 in breast cancer cell lines were evaluated by examinations of cell proliferation, migration and cell cycle.
[Journal of Experimental & Clinical Cancer Research]
Wang, X., Ji, C., Hu, J., Deng, X., Zheng, W., Yu, Y., Hua, K., Zhou, X., & Fang, L. (2021). Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway. Journal of Experimental & Clinical Cancer Research, 40(1), 29. https://doi.org/10.1186/s13046-021-01830-z Cite
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Lipoxygenase Catalyzed Metabolites Derived from Docosahexaenoic Acid Are Promising Antitumor Agents Against Breast Cancer

The authors investigated whether docosahexaenoic acid itself or select metabolites can account for its antitumor action.
[Scientific Reports]
Chen, K.-M., Thompson, H., Vanden-Heuvel, J. P., Sun, Y.-W., Trushin, N., Aliaga, C., Gowda, K., Amin, S., Stanley, B., Manni, A., & El-Bayoumy, K. (2021). Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer. Scientific Reports, 11(1), 410. https://doi.org/10.1038/s41598-020-79716-x Cite
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Exosomal LINC00161 Promotes Angiogenesis and Metastasis via Regulating miR-590-3p/ROCK Axis in Hepatocellular Carcinoma

Functional study demonstrated that exosomal LINC00161 derived from hepatocellular carcinoma (HCC)-cells were significantly associated with enhanced proliferation, migration, and angiogenesis in HUVECs in vitro, all of which were effectively inhibited when LINC00161 was sliced with shRNA in HCC-cells.
[Cancer Gene Therapy]
You, L.-N., Tai, Q.-W., Xu, L., Hao, Y., Guo, W.-J., Zhang, Q., Tong, Q., Zhang, H., & Huang, W.-K. (2021). Exosomal LINC00161 promotes angiogenesis and metastasis via regulating miR-590-3p/ROCK axis in hepatocellular carcinoma. Cancer Gene Therapy, 1–18. https://doi.org/10.1038/s41417-020-00269-2 Cite
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UTX/KDM6A Deletion Promotes the Recovery of Spinal Cord Injury by Epigenetically Triggering Intrinsic Neural Regeneration

Scientists elucidated the role of the epigenetic regulatory network involving ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX)/miR-24/NeuroD1 in axonal regeneration and functional recovery in mice following spinal cord injury (SCI). They showed that UTX was significantly increased post-SCI and repressed axonal regeneration in vitro.
[Molecular Therapy-Methods & Clinical Development]
UTX/KDM6A deletion promotes the recovery of spinal cord injury by epigenetically triggering intrinsic neural regeneration: Molecular Therapy - Methods & Clinical Development. (n.d.). Retrieved December 14, 2020, from https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(20)30252-7 Cite
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hCINAP Serves a Critical Role in Hypoxia‑Induced Cardiomyocyte Apoptosis via Modulating Lactate Production and Mitochondrial‑Mediated Apoptosis Signaling

Compared with the siRNA‑Ctrl group, human coilin interacting nuclear ATPase protein (hCINAP) knockdown inhibited apoptosis, whereas compared with the vector group, hCINAP overexpression increased apoptosis under hypoxic conditions. Mechanistically, compared with the siRNA‑Ctrl group, hCINAP knockdown decreased hypoxia‑induced lactate accumulation via regulating lactate dehydrogenase A activity.
[Molecular Medicine Reports]
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MicroRNA-let-7e in Serum-Derived Exosomes Inhibits the Metastasis of Non-Small-Cell Lung Cancer in a SUV39H2/LSD1/CDH1-Dependent Manner

Researchers evaluated the clinical significance of serum-derived exosomal miR-let-7e as a biomarker in the metastasis of non-small-cell lung cancer.
[Cancer Gene Therapy]
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Autism-Associated miR-873 Regulates ARID1B, SHANK3 and NRXN2 Involved in Neurodevelopment

A dual-luciferase reporter assay confirmed miR-873 variants have a 20-30% inhibition/dysregulation effect on candidate autism risk genes ARID1B, SHANK3 and NRXN2 and also confirmed the affected expression with qPCR.
[Translational Psychiatry]
Lu, J., Zhu, Y., Williams, S., Watts, M., Tonta, M. A., Coleman, H. A., Parkington, H. C., & Claudianos, C. (2020). Autism-associated miR-873 regulates ARID1B, SHANK3 and NRXN2 involved in neurodevelopment. Translational Psychiatry, 10(1), 1–12. https://doi.org/10.1038/s41398-020-01106-8 Cite
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