Circular RNA AFF4 Modulates Osteogenic Differentiation in BM-MSCs by Activating SMAD1/5 Pathway through miR-135a-5p/FNDC5/Irisin Axis

Researchers investigated molecular mechanisms underlying circular RNA AFF4-regulated Bone marrow-derived-MSCs osteogenesis.
[Cell Death & Disease]
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Kaempferol Inhibits Benign Prostatic Hyperplasia by Resisting the Action of Androgen

Molecular docking, cellular immunofluorescence staining, chromatin immunoprecipitation, and dual luciferase reporter assay were performed to investigate the androgenic activity of kaempferol.
[European Journal of Pharmacology]
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Hypoxia-Inducible Exosomes Facilitate Liver-Tropic Pre-Metastatic Niche in Colorectal Cancer

Researchers demonstrated that the hypoxic microenvironment in primary colorectal cancer lesions boosted exosome release and selectively initiated a favorable pre-metastatic niche formation in the hepar, but not in other organs.
[Hepatology]
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miR-141-5p Suppresses Vascular Smooth Muscle Cell Inflammation, Proliferation, and Migration via Inhibiting the HMGB1/NF-κB Pathway

Using human vascular smooth muscle cells (VSMCs) treated by oxidized low-density lipoprotein to establish an atherosclerosis cell model, researchers explored the functional roles and molecular mechanisms of miR-141-5p in VSMCs dysfunction.
[Journal of Biochemical and Molecular Toxicology]
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HDAC4 Induces the Development of Asthma by Increasing Slug-Upregulated CXCL12 Expression through KLF5 Deacetylation

Researchers used asthma model bronchial smooth muscle cells to measure the biological behaviors of Histone deacetylase 4 (HDAC4)-mediated Kruppel-like factor 5 (KLF5)/Slug/CXC chemokine ligand-12 (CXCL12) axis on the development of asthma in regulation of airway inflammation and remodeling.
[Journal of Translational Medicine]
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LncRNA MAGI2-AS3 Inhibits Tumor Progression and Angiogenesis by Regulating ACY1 via Interacting with Transcription Factor HEY1 in Clear Cell Renal Cell Carcinoma

Angiogenesis was evaluated in the Matrigel-based human umbilical vein endothelial cell-RLC-310 coculture model and immunohistochemical staining for vascular endothelial growth factor and CD31 in tumor tissues collected from a xenograft ccRCC mouse model.
[Cancer Gene Therapy]
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MiR-205-5p Suppresses Angiogenesis in Gastric Cancer by Downregulating the Expression of VEGFA and FGF1

To help identify new strategies for antiangiogenic therapy in gastric cancer (GC), scientists evaluated miR-205-5p expression in GC tissues from TCGA database and our hospital, and its functions in angiogenesis were explored in vitro and in vivo.
[Experimental Cell Research]
Zhang, J., Zhang, J., Pang, X., Chen, Z., Zhang, Z., Lei, L., Xu, H., Wen, L., Zhu, J., Jiang, Y., Cui, Y., Chen, G., & Wang, X. (2021). MiR-205-5p suppresses angiogenesis in gastric cancer by downregulating the expression of VEGFA and FGF1. Experimental Cell Research, 112579. https://doi.org/10.1016/j.yexcr.2021.112579 Cite
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LncRNA SLCO4A1-AS1 Modulates Colon Cancer Stem Cell Properties by Binding to miR-150-3p and Positively Regulating SLCO4A1

The authors explored the specific role of solute carrier organic anion transporter family member 4A1-AS1 (SLCO4A1-AS1) in colon CSCs.
[Laboratory Investigation]
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LncRNA DANCR Targets miR-185-5p to Upregulate LIM and SH3 Protein 1 (LASP1) Promoting Prostate Cancer via the FAK/PI3K/AKT/GSK3β/Snail Pathway

Investigators explored the lncRNA DANCR mechanism in facilitating the malignancy of prostate cancer.
[Journal of Gene Medicine]
Sun, W., Zu, S., Shao, G., Wang, W., & Gong, F. (n.d.). LncRNA DANCR targets miR-185-5p to upregulate LIM and SH3 protein 1 (LASP1) promoting prostate cancer via the FAK/PI3K/AKT/GSK3β/Snail pathway. The Journal of Gene Medicine, n/a(n/a), e3344. https://doi.org/https://doi.org/10.1002/jgm.3344 Cite
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Long Noncoding RNA SNHG9 Facilitates Growth of Glioma Stem-Like Cells via miR-326/SOX9 Axis

Glioma stem cells (GSCs) were obtained from glioma cells and referred to as GSC‐87 and GSC‐251, respectively. The interactions between miR‐326 and SNHG9 or SOX9 were analyzed using luciferase reporter assay.
[Journal of Gene Medicine]
Wang, C.-J., Chao, C.-R., Zhao, W.-F., Liu, H.-M., Feng, J.-S., & Cui, Y.-X. (n.d.). Long noncoding RNA SNHG9 facilitates growth of glioma stem-like cells via miR-326/SOX9 axis. The Journal of Gene Medicine, n/a(n/a), e3334. https://doi.org/https://doi.org/10.1002/jgm.3334 Cite
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HIF-1α Promoted Vasculogenic Mimicry Formation in Lung Adenocarcinoma through NRP1 Upregulation in the Hypoxic Tumor Microenvironment

Researchers explored the role of the HIF-1α/NRP1 axis in mediating lung adenocarcinoma metastasis and vasculogenic mimicry (VM) formation.
[Cell Death & Disease]
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