Extracellular Vesicles Derived from Hypoxia-Preconditioned Olfactory Mucosa Mesenchymal Stem Cells Enhance Angiogenesis via miR-612

Investigators explored the effects of extracellular vesicles from human hypoxic olfactory mucosa MSCs on angiogenesis and its underlying mechanism.
[Journal of Nanobiotechnology]
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Transcription Factor p53-Mediated Activation of miR-519d-3p and Downregulation of E2F1 Attenuates Prostate Cancer Growth and Metastasis

Investigators uncovered that the transcription factor p53 could upregulate miR-519d-3p expression to directly suppress the expression of E2F transcription factor 1 (E2F1), thus inhibiting prostate cancer growth and metastasis.
[Cancer Gene Therapy]
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MiR-455-5p Upregulation in Umbilical Cord Mesenchymal Stem Cells Attenuates Endometrial Injury and Promotes Repair of Damaged Endometrium via Janus Kinase/Signal Transducer and Activator of Transcription 3 Signaling

Scientists investigated the specific impacts of umbilical cord mesenchymal stem cells overexpressing miR-455-5p in intrauterine adhesions.
[Bioengineered]
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EGR1 Modulated LncRNA HNF1A-AS1 Drives Glioblastoma Progression via miR-22-3p/ENO1 Axis

Accumulating evidence revealed that long noncoding RNAs (lncRNAs) have been participating in cancer malignant progression, including glioblastoma multiforme (GBM). Scientists illuminated the definite mechanism of HNF1A-AS1 in promoting GBM malignancy.
[Cell Death Discovery]
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Circ_0057583 Facilitates Brain Microvascular Endothelial Cell Injury through Modulating miR-204-5p/NR4A1 Axis

Investigators explored the potential role and mechanism of circ_0057583 in brain microvascular endothelial cell injury. Human brain microvascular endothelial cells were exposed to different doses of lipopolysaccharide to induce cell damage.
[Metabolic Brain Disease]
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Overexpression of miR-122 Promotes Apoptosis of Dermal Papilla Cells by Directly Targeting IGF1R in Androgenetic Alopecia

Researchers suggested that upregulation of miR-122 induced apoptosis, potentially via the repression of insulin-like growth factor 1 receptor (IGF1R) in human dermal papilla cells of androgenetic alopecia.
[Cell Biology International]
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Tumor Suppressor LHX6 Upregulation Contributes to the Inhibitory Effect of miR-346 Knockdown on Colorectal Cancer Cell Growth

Dysregulated miRNAs have been promulgated as oncogenes or tumor-suppressive genes participating in the initiation and progression of colorectal cancer (CRC). Scientists reported that miR-346 was highly expressed in CRC patients.
[Environmental Toxicology]
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lncRNA FOXD3-AS1 Promotes the Progression of Non-small Cell Lung Cancer by Regulating the miR-135a-5p/CDK6 Axis

The molecular mechanism underlying the role of FOXD3‑AS1 in cancer development has not yet been fully elucidated. Researchers focused on non‑small cell lung cancer in order to gain insight into how FOXD3‑AS1 drives cancer progression.
[Oncology Letters]
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CircSKA3 Acts as a Sponge of miR-6796-5p to Be Associated with Outcomes of Ischemic Stroke by Regulating MMP9 Expression

The authors screened the circular RNAs (circRNA) influencing matrix metalloproteinase-9 (MMP9) through the competing endogenous RNA network and evaluated the prognostic value of these circRNAs for acute ischemic stroke.
[European Journal of Neurology]
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Astragalus Polysaccharide Improve the Proliferation and Insulin Secretion of Mouse Pancreatic β Cells Induced by High Glucose and Palmitic Acid Partially through Promoting miR-136-5p and miR-149-5p Expression

The effect of astragalus polysaccharide on dysfunctional insulin cells was investigated to clarify whether astragalus polysaccharide could be a novel drug for type 2 diabetes mellitus treatment.
[Bioengineered]
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A Novel lncRNA ROPM-Mediated Lipid Metabolism Governs Breast Cancer Stem Cell Properties

Researchers highlight that lncROPM and its target PLA2G16 played crucial roles in sustaining breast CSC (BCSC) properties and might serve as a biomarker for BCSCs or other cancer stem cells.
[Journal of Hematology & Oncology]
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