Scientists investigated the function and mechanism underlying how miR-541-3p modulates the radiosensitivity of prostate cancer cells by regulating HSP27.
[Cell Death Discovery]
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Investigators found the level of small nucleolar RNA host gene 1 (SNHG1) was significantly upregulated in prostate cancer tissues and cells. Knockdown of SNHG1 significantly suppressed proliferation, migration and invasion and promoted cell apoptosis in prostate cancer cells.
Investigators explored the function and mechanism of LINC01152 in glioblastoma multiforme (GBM). Then qRT-PCR analysis was implemented to search the expression of RNAs in GBM tissues and cells.
[Cell Death & Disease]
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GAS6-AS2 was identified, and its roles as well as mechanisms in regulating proliferation of non-small cell lung cancer cells were investigated.
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The effect of knocking down hsa_circ_0005273 in breast cancer cell lines were evaluated by examinations of cell proliferation, migration and cell cycle.
[Journal of Experimental & Clinical Cancer Research]
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Wang, X., Ji, C., Hu, J., Deng, X., Zheng, W., Yu, Y., Hua, K., Zhou, X., & Fang, L. (2021). Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway. Journal of Experimental & Clinical Cancer Research, 40(1), 29. https://doi.org/10.1186/s13046-021-01830-z Cite
The authors investigated whether docosahexaenoic acid itself or select metabolites can account for its antitumor action.
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Chen, K.-M., Thompson, H., Vanden-Heuvel, J. P., Sun, Y.-W., Trushin, N., Aliaga, C., Gowda, K., Amin, S., Stanley, B., Manni, A., & El-Bayoumy, K. (2021). Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer. Scientific Reports, 11(1), 410. https://doi.org/10.1038/s41598-020-79716-x Cite
Functional study demonstrated that exosomal LINC00161 derived from hepatocellular carcinoma (HCC)-cells were significantly associated with enhanced proliferation, migration, and angiogenesis in HUVECs in vitro, all of which were effectively inhibited when LINC00161 was sliced with shRNA in HCC-cells.
[Cancer Gene Therapy]
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You, L.-N., Tai, Q.-W., Xu, L., Hao, Y., Guo, W.-J., Zhang, Q., Tong, Q., Zhang, H., & Huang, W.-K. (2021). Exosomal LINC00161 promotes angiogenesis and metastasis via regulating miR-590-3p/ROCK axis in hepatocellular carcinoma. Cancer Gene Therapy, 1–18. https://doi.org/10.1038/s41417-020-00269-2 Cite
Scientists elucidated the role of the epigenetic regulatory network involving ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX)/miR-24/NeuroD1 in axonal regeneration and functional recovery in mice following spinal cord injury (SCI). They showed that UTX was significantly increased post-SCI and repressed axonal regeneration in vitro.
[Molecular Therapy-Methods & Clinical Development]
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UTX/KDM6A deletion promotes the recovery of spinal cord injury by epigenetically triggering intrinsic neural regeneration: Molecular Therapy - Methods & Clinical Development. (n.d.). Retrieved December 14, 2020, from https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(20)30252-7 Cite
Compared with the siRNA‑Ctrl group, human coilin interacting nuclear ATPase protein (hCINAP) knockdown inhibited apoptosis, whereas compared with the vector group, hCINAP overexpression increased apoptosis under hypoxic conditions. Mechanistically, compared with the siRNA‑Ctrl group, hCINAP knockdown decreased hypoxia‑induced lactate accumulation via regulating lactate dehydrogenase A activity.
[Molecular Medicine Reports]
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Researchers evaluated the clinical significance of serum-derived exosomal miR-let-7e as a biomarker in the metastasis of non-small-cell lung cancer.
[Cancer Gene Therapy]
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A dual-luciferase reporter assay confirmed miR-873 variants have a 20-30% inhibition/dysregulation effect on candidate autism risk genes ARID1B, SHANK3 and NRXN2 and also confirmed the affected expression with qPCR.
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