Inhibitory Effect of MicroRNA-608 on Lung Cancer Cell Proliferation, Migration, and Invasion by Targeting BRD4 through the JAK2/STAT3 Pathway

Investigators determined the fundamental mechanism of microRNA-608 in the development of lung cancer.
[Bosnian Journal of Basic Medical Sciences]
Xu, W., Sun, D., Wang, Y., Zheng, X., Li, Y., Xia, Y., & Teng, Y. (2020). Inhibitory effect of microRNA-608 on lung cancer cell proliferation, migration, and invasion by targeting BRD4 through the JAK2/STAT3 pathway. Bosnian Journal of Basic Medical Sciences, 20(3), 347–356. https://doi.org/10.17305/bjbms.2019.4216 Cite
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LncRNA KCNQ1OT1 Regulates the Invasion and Migration of Hepatocellular Carcinoma by Acting on S1PR1 through miR-149

A xenograft tumour assay was used to validate the role of KCNQ1OT1 in vivo. KCNQ1OT1 and S1PR1 were significantly increased, but miR-149 was decreased in HCC cells.
[Cancer Gene Therapy]
Cheng, J.-L., Li, D.-J., Lv, M.-Y., Pei, Y.-J., Zhang, X.-J., Li, L., Liu, X.-Y., & Fan, A.-H. (2020). LncRNA KCNQ1OT1 regulates the invasion and migration of hepatocellular carcinoma by acting on S1PR1 through miR-149. Cancer Gene Therapy, 1–14. https://doi.org/10.1038/s41417-020-0203-x Cite
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MicroRNA-148a-3p Inhibits Progression of Hepatocelluar Carcimoma by Repressing SMAD2 Expression in an Ago2 Dependent Manner

Investigators found that SMAD2 was highly expressed in hepatocellular carcinoma (HCC) and elevated SMAD2 expression predicted shorter overall survival time for HCC patients. SMAD2 promoted mobility and proliferation of HCC cells in vitro.
[Journal of Experimental & Clinical Cancer Research]
Huang, Z., Wen, J., Yu, J., Liao, J., Liu, S., Cai, N., Liang, H., Chen, X., Ding, Z., & Zhang, B. (2020). MicroRNA-148a-3p inhibits progression of hepatocelluar carcimoma by repressing SMAD2 expression in an Ago2 dependent manner. Journal of Experimental & Clinical Cancer Research, 39(1), 150. https://doi.org/10.1186/s13046-020-01649-0 Cite
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LINC00324 Affects Non-Small Cell Lung Cancer Cell Proliferation and Invasion through Regulation of the miR-139-5p/IGF1R Axis

Scientists demonstrated whether LINC00324 participates in non-small cell lung cancer pathogenesis through other molecular mechanism.
[Molecular and Cellular Biochemistry]
Zhang, M., Lin, B., Liu, Y., Huang, T., Chen, M., Lian, D., Deng, S., & Zhuang, C. (2020). LINC00324 affects non-small cell lung cancer cell proliferation and invasion through regulation of the miR-139-5p/IGF1R axis. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-020-03819-2 Cite
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EGF-Mediated Reduced miR-92a-1-5p Controls HTR-8/SVneo Cell Invasion through Activation of MAPK8 and FAS which in turn Increase MMP-2/-9 Expression

The binding of miR-92a-1-5p to MAPK8 and FAS 3′-UTR was confirmed by Luciferase reporter assay and Rescue assay. EGF increased MMP-2 & MMP-9 expression and reduced TIMP1 expression in HTR-8/SVneo cells.
[Scientific Reports]
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