MiR-30d Suppresses Proliferation and Invasiveness of Pancreatic Cancer by Targeting the SOX4/PI3K-AKT Axis and Predicts Poor Outcome

The role of miR-30d in the proliferation and metastasis of pancreatic cancer cells was determined using in vitro and in vivo assays.
[Cell Death & Disease]
Xu, X., Zong, K., Wang, X., Dou, D., Lv, P., Zhang, Z., & Li, H. (2021). miR-30d suppresses proliferation and invasiveness of pancreatic cancer by targeting the SOX4/PI3K-AKT axis and predicts poor outcome. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03576-0 Cite
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Rosiglitazone Attenuates High Glucose-Induced Proliferation, Inflammation, Oxidative Stress and Extracellular Matrix Accumulation in Mouse Mesangial Cells through the Gm26917/miR-185-5p Pathway

Rosiglitazone significantly inhibited high glucose-induced proliferation, oxidative stress, inflammatory responses and extracellular matrix accumulation in mouse mesangial cells.
[Endocrine Journal]
Zhao, D., Guo, J., Liu, L., & Huang, Y. (2021). Rosiglitazone attenuates high glucose-induced proliferation, inflammation, oxidative stress and extracellular matrix accumulation in mouse mesangial cells through the Gm26917/miR-185-5p pathway. Endocrine Journal, advpub. https://doi.org/10.1507/endocrj.EJ20-0783 Cite
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CircRNA RSF1 Regulated Ox-LDL Induced Vascular Endothelial Cells Proliferation, Apoptosis and Inflammation through Modulating miR-135b-5p/HDAC1 Axis in Atherosclerosis

ox-LDL inhibited circRSF1 and histone deacetylase 1 (HDAC1) expression while upregulated miR-135b-5p expression in HUVECs.
[Biological Research]
Zhang, X., Lu, J., Zhang, Q., Luo, Q., & Liu, B. (2021). CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis. Biological Research, 54(1), 11. https://doi.org/10.1186/s40659-021-00335-5 Cite
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LINC01419-Mediated Epigenetic Silencing of ZIC1 Promotes Metastasis in Hepatocellular Carcinoma through thePI3K/Akt Signaling Pathway

LINC01419 enhances the methylation of zinc finger of the cerebellum (ZIC1) promoter, inhibits ZIC1 expression, and activates the PI3K/Akt signaling pathway, thereby enhancing the malignant phenotypes of hepatocellular carcinoma cells in vitro as well as tumor formation and metastasis in vivo.
[Laboratory Investigation]
Hou, Y., Chen, K., Liao, R., Li, Y., Yang, H., & Gong, J. (2021). LINC01419-mediated epigenetic silencing of ZIC1 promotes metastasis in hepatocellular carcinoma through the PI3K/Akt signaling pathway. Laboratory Investigation, 1–18. https://doi.org/10.1038/s41374-021-00539-z Cite
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Circ-HMGA2 (hsa_circ_0027446) Promotes the Metastasis and Epithelial-Mesenchymal Transition of Lung Adenocarcinoma Cells through the miR-1236-3p/ZEB1 Axis

Through microarray analysis, investigators obtained the circRNA expression profile of lung adenocarcinoma and found that circ-HMGA2, a novel RNA, was highly expressed in lung adenocarcinoma.
[Cell Death & Disease]
Circ-HMGA2 (hsa_circ_0027446) promotes the metastasis and epithelial-mesenchymal transition of lung adenocarcinoma cells through the miR-1236-3p/ZEB1 axis | Cell Death & Disease. (n.d.). Retrieved March 25, 2021, from https://www.nature.com/articles/s41419-021-03601-2 Cite
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Tissue-Specific Transplantation Antigen P35B Functions as an Oncogene and is Regulated by Microrna-125a-5p in Lung Cancer

Researchers demonstrated that tissue‑specific transplantation antigen P35B (TSTA3) was regulated by miR‑125a‑5p and functions as an oncogene in lung cancer via promoting the activation of β‑catenin signaling.
[Oncology Reports]
Gao, Y., Zhang, G., Liu, J., & Li, H. (2021). Tissue-specific transplantation antigen P35B functions as an oncogene and is regulated by microRNA-125a-5p in lung cancer. Oncology Reports, 45(5), 1–13. https://doi.org/10.3892/or.2021.8023 Cite
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miR‑454‑3p Inhibits Non‑Small Cell Lung Cancer Cell Proliferation and Metastasis by Targeting TGFB2

miR‑454‑3p overexpression led to the suppression of proliferation, migration, and invasion in A549 and NCI‑H1650 cells. The overexpression of miR‑454‑3p in A549 and NCI‑H1650 cells significantly inhibited EMT. TGFB2 was revealed to be a direct target of miR‑454‑3p by using TargetScan database and luciferase reporter assay.
[Oncology Reports]
Liao, H., Liang, Y., Kang, L., Xiao, Y., Yu, T., & Wan, R. (2021). miR‑454‑3p inhibits non‑small cell lung cancer cell proliferation and metastasis by targeting TGFB2. Oncology Reports, 45(5), 1–12. https://doi.org/10.3892/or.2021.8018 Cite
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MALAT1 Maintains the Intestinal Mucosal Homeostasis in Crohn’s Disease via the miR-146b-5p-CLDN11/NUMB Pathway

Effects of intestinal epithelial cells transfected with metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) lentiviruses and Smart Silencer, on monolayer permeability and apical junction complex proteins were analyzed.
[Journal of Crohns & Colitis]
Li, Y., Zhu, L., Chen, P., Wang, Y., Yang, G., Zhou, G., Li, L., Feng, R., Qiu, Y., Han, J., Chen, B., He, Y., Zeng, Z., Chen, M., & Zhang, S. (2021). MALAT1 maintains the intestinal mucosal homeostasis in Crohn’s disease via the miR-146b-5p-CLDN11/NUMB pathway. Journal of Crohn’s and Colitis, jjab040. https://doi.org/10.1093/ecco-jcc/jjab040 Cite
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Circ_0074027 Contributes to Non‐Small Cell Lung Cancer Progression through Positively Modulating RHOA via Sequestering miR-2467-3p

RNA_0074027 (Circ_0074027) interacted with microRNA-2467-3p (miR-2467-3p), and ras homolog family member A (RHOA) was a target of miR-2467-3p in NSCLC cells. RHOA silencing blocked the malignant potential of NSCLC cells. Circ_0074027 silencing restrained the malignant phenotypes of NSCLC cells largely through up-regulating miR-2467-3p.
[Journal of Bioenergetics and Biomembranes]
Circ_0074027 contributes to non‐small cell lung cancer progression through positively modulating RHOA via sequestering miR-2467-3p | SpringerLink. (n.d.). Retrieved March 11, 2021, from https://link.springer.com/article/10.1007%2Fs10863-021-09876-6 Cite
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Curcumin Suppresses the Malignancy of Non-Small Cell Lung Cancer by Modulating the circ-PRKCA/miR-384/ITBG1 Pathway

Curcumin inhibited NSCLC growth through downregulating circ-PRKCA, which regulated ITGB1 expression by adsorbing miR-384.
[Biomedicine & Pharmacotherapy]
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LINC01089 Functions as a ceRNA for miR-152-3p to Inhibit Non‐Small Lung Cancer Progression through Regulating PTEN

Down-regulation of LINC01089 promoted the progression of NSCLC through regulating miR-152-3p/PTEN axis.
[Cancer Cell International]
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