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reporter assay

ZMAT1 Acts as a Tumor Suppressor in Pancreatic Ductal Adenocarcinoma by Inducing SIRT3/p53 Signaling Pathway

[Journal of Experimental & Clinical Cancer Research] Multiple bioinformatics analyses were used to evaluate zinc finger matrin-type 1 (ZMAT1) expression and potential role in PDAC.In vitro and in vivo studies were performed to assess the effects of ZMAT1 on PDAC cells growth.

A Noncoding Regulatory RNA Gm31932 Induces Cell Cycle Arrest and Differentiation in Melanoma via the MiR-344d-3-5p/Prc1 (and Nuf2) Axis

[Cell Death & Disease] Integrative analysis of whole transcriptome sequencing data demonstrated that lncRNA-Gm31932 was significantly decreased in all-trans retinoic acid-induced and sodium 4-phenylbutanoate-induced mouse melanoma B16 cells.

LncRNA FAF Attenuates Hypoxia/Ischaemia-Induced Pyroptosis via the miR-185-5p/PAK2 Axis in Cardiomyocytes

[Journal of Cellular and Molecular Medicine] Investigators explored the antipyroptotic effects of long noncoding RNA (lncRNA) FGF9-associated factor (FAF) in acute myocardial infarction.

Downregulation of lncRNA NEAT1 Relieves Caerulein-Induced Cell Apoptosis and Inflammatory Injury in AR42J Cells through Sponging MiR-365a-3p in Acute Pancreatitis

[Biochemical Genetics] Investigators explored the role of long-noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) in acute pancreatitis that was induced by caerulein in rat pancreatic acinar cells AR42J.

Downregulation of Kcnq1ot1 Attenuates β-Cell Proliferation and Insulin Secretion via the MiR-15b-5p/Ccnd1 and Ccnd2 Axis

[Acta Diabetologica] CCK8, Ki67 staining, immunohistochemical analyses, glucose-stimulated insulin secretion and intraperitoneal glucose tolerance test were performed to detect the effect of Kcnq1ot1 on β-cell proliferation and insulin secretion in vitro and in vivo.

CircTHBS1 Drives Gastric Cancer Progression by Increasing INHBA mRNA Expression and Stability in a CeRNA- and RBP-Dependent Manner

[Cell Death & Disease] Transcriptome analysis and self-organizing maps were applied to screen backbone circular RNAs in gastric cancer.

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