Human Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury under High Glucose via TLR2 and TLR4 Signaling

Scientists investigated the effects of high glucose on the innate immunity of podocytes and diabetic nephropathy mice via Toll like receptor signaling, and explored the protective effects of human umbilical cord MSCs on this process.
[Diabetes Research and Clinical Practice]
Wang, Y., Liu, J., Zhang, Q., Wang, W., Liu, Q., Liu, S., Song, Y., Wang, X., Zhang, Y., Li, S., Yang, X., Lv, S., & Liu, G. (2021). Human Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury under High Glucose via TLR2 and TLR4 Signaling. Diabetes Research and Clinical Practice, 0(0). https://doi.org/10.1016/j.diabres.2021.108702 Cite
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Human Mesenchymal Stem Cells Promote Ischemic Repairment and Angiogenesis of Diabetic Foot through Exosome miRNA-21-5p

Exosomes were isolated from MSCs using ultracentrifugation, and further characterized by the nanoparticle tracking analyzer and flow cytometry. RNA sequencing, Western Blot, in vitro cell proliferation, in vivo pro-angiogenesis, as well as ischemic repairment of diabetic foot through rat model were performed to evaluate exosome physiological functions.
[Stem Cell Research]
Huang, C., Luo, W., Wang, Q., Ye, Y., Fan, J., Lin, L., Shi, C., Wei, W., Chen, H., Wu, Y., & Tang, Y. (2021). Human mesenchymal stem cells promote ischemic repairment and angiogenesis of diabetic foot through exosome miRNA-21-5p. Stem Cell Research, 52, 102235. https://doi.org/10.1016/j.scr.2021.102235 Cite
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Human Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury under High Glucose via TLR2 and TLR4 Signaling

Scientists investigated the effects of high glucose on the innate immunity of podocytes and diabetic nephropathy mice via Toll like receptor (TLR) signaling, and explored the protective effects of human umbilical cord-MSCs on this process.
[Diabetes Research and Clinical Practice]
Wang, Y., Liu, J., Zhang, Q., Wang, W., Liu, Q., Liu, S., Song, Y., Wang, X., Zhang, Y., Li, S., Yang, X., Lv, S., & Liu, G. (2021). Human Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury under High Glucose via TLR2 and TLR4 Signaling. Diabetes Research and Clinical Practice, 0(0). https://doi.org/10.1016/j.diabres.2021.108702 Cite
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Moringa oleifera Leaf Extracts Protect BMSC Osteogenic Induction Following Peroxidative Damage by Activating the PI3K/Akt/Foxo1 Pathway

Researchers investigated the therapeutic effects of Moringa oleifera leaf extracts on osteogenic induction of rat bone marrow MSCs (BMSCs) following peroxidative damage and to explore the underlying mechanisms.
[Journal of Orthopaedic Surgery and Research]
Liu, M., Ding, H., Wang, H., Wang, M., Wu, X., Gan, L., Cheng, L., & Li, X. (2021). Moringa oleifera leaf extracts protect BMSC osteogenic induction following peroxidative damage by activating the PI3K/Akt/Foxo1 pathway. Journal of Orthopaedic Surgery and Research, 16(1), 150. https://doi.org/10.1186/s13018-021-02284-x Cite
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Lactonic Sophorolipid–Induced Apoptosis in Human HepG2 Cells through the Caspase-3 Pathway

The effects of lactonic sophorolipids and cell death inhibitors were measured by MTT test on HepG2 cells. Their morphology of the cells was observed under a microscope.
[Applied Microbiology and Biotechnology]
Wang, X., Xu, N., Li, Q., Chen, S., Cheng, H., Yang, M., Jiang, T., Chu, J., Ma, X., & Yin, D. (2021). Lactonic sophorolipid–induced apoptosis in human HepG2 cells through the Caspase-3 pathway. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-020-11045-5 Cite
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The Combination Effect of Prominin1 (CD133) Suppression and Oxaliplatin Treatment in Colorectal Cancer Therapy

Scientists checked the combined effect of CD133 siRNA and Oxaliplatin on proliferation, migration, apoptosis, and stemness properties of olorectal cancer cells in the HT-29 cell line.
[Biomedicine & Pharmacotherapy]
Asadzadeh, Z., Mansoori, B., Mohammadi, A., Kazemi, T., Mokhtarzadeh, A., Shanehbandi, D., Hemmat, N., Derakhshani, A., Brunetti, O., Safaei, S., Aghajani, M., Najafi, S., Silvestris, N., & Baradaran, B. (2021). The combination effect of Prominin1 (CD133) suppression and Oxaliplatin treatment in colorectal cancer therapy. Biomedicine & Pharmacotherapy, 137, 111364. https://doi.org/10.1016/j.biopha.2021.111364 Cite
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Comparative Analysis of Assays to Measure CAR T-cell-Mediated Cytotoxicity

The authors highlight the US FDA directives for a potency assay for release of clinical cell therapy products.
[Nature Protocols]
Kiesgen, S., Messinger, J. C., Chintala, N. K., Tano, Z., & Adusumilli, P. S. (2021). Comparative analysis of assays to measure CAR T-cell-mediated cytotoxicity. Nature Protocols, 1–12. https://doi.org/10.1038/s41596-020-00467-0 Cite
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Analysis of Classical Neutrophils and Polymorphonuclear Myeloid-Derived Suppressor Cells in Cancer Patients and Tumor-Bearing Mice

Using single-cell RNA-seq, cell mass spectrometry, flow cytometry, and functional analysis, investigators characterized the heterogeneity of polymorphonuclear neutrophils in cancer.
[Journal of Experimental Medicine]
Veglia, F., Hashimoto, A., Dweep, H., Sanseviero, E., De Leo, A., Tcyganov, E., Kossenkov, A., Mulligan, C., Nam, B., Masters, G., Patel, J., Bhargava, V., Wilkinson, P., Smirnov, D., Sepulveda, M. A., Singhal, S., Eruslanov, E. B., Cristescu, R., Loboda, A., … Gabrilovich, D. I. (2021). Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice. Journal of Experimental Medicine, 218(e20201803). https://doi.org/10.1084/jem.20201803 Cite
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The Lectin-Like Domain of Thrombomodulin Inhibits β1 Integrin-Dependent Binding of Human Breast Cancer-Derived Cell Lines to Fibronectin

Using a V-well cell adhesion assay or flow cytometry analysis with fluorescent beads, the authors found that both TM domain 12-Fc and TM domain 23-Fc inhibited the binding between β1 integrin of human breast cancer-derived cell lines and fibronectin.
[Biomedicines]
Kawamoto, E., Nago, N., Okamoto, T., Gaowa, A., Masui-Ito, A., Akama, Y., Darkwah, S., Appiah, M. G., Myint, P. K., Obeng, G., Ito, A., Caidengbate, S., Esumi, R., Yamaguchi, T., Park, E. J., Imai, H., & Shimaoka, M. (2021). The Lectin-Like Domain of Thrombomodulin Inhibits β1 Integrin-Dependent Binding of Human Breast Cancer-Derived Cell Lines to Fibronectin. Biomedicines, 9(2), 162. https://doi.org/10.3390/biomedicines9020162 Cite
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Modulatory Activity of Adenosine on the Immune Response in Cord and Adult Blood

Impact of adenosine on peripheral and cord blood mononuclear cells was analyzed by quantification of ectonucleotidases and adenosine receptor expression.
[Pediatric Research]
Ďurčo, F., Köstlin-Gille, N., Poets, C. F., & Gille, C. (2021). Modulatory activity of adenosine on the immune response in cord and adult blood. Pediatric Research, 1–9. https://doi.org/10.1038/s41390-020-01275-8 Cite
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Radiation Response of Cervical Cancer Stem Cells Is Associated with Pretreatment Proportion of These Cells and Physical Status of HPV DNA

Scientists evaluated the association of radiation response of cervical CSCs with clinical and morphological parameters of disease and features of human papillomavirus (HPV) infection.
[International Journal of Molecular Sciences]
Zamulaeva, I., Selivanova, E., Matchuk, O., Kiseleva, V., Mkrtchyan, L., & Krikunova, L. (2021). Radiation Response of Cervical Cancer Stem Cells Is Associated with Pretreatment Proportion of These Cells and Physical Status of HPV DNA. International Journal of Molecular Sciences, 22(3), 1445. https://doi.org/10.3390/ijms22031445 Cite
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