Overexpressed sFRP3 Exerts an Inhibitory Effect on Hepatocellular Carcinoma via Inactivation of the Wnt/β-Catenin Signaling Pathway

Researchers investigated the possible regulatory effects of a secreted frizzled-related protein (sFRP3) on the Wnt/β-catenin signaling pathway and their interactions in hepatocellular carcinoma occurrence.
[Cancer Gene Therapy]
Fang, L., Gao, C., Bai, R.-X., Wang, H.-F., & Du, S.-Y. (2020). Overexpressed sFRP3 exerts an inhibitory effect on hepatocellular carcinoma via inactivation of the Wnt/β-catenin signaling pathway. Cancer Gene Therapy, 1–17. https://doi.org/10.1038/s41417-020-0201-z Cite
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Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas

Scientists interrogated purified sorted tumor fractions from a series of 15 tumor samples with whole-genome copy-number variant, whole-exome sequencing, and assay for transposase-accessible chromatin using sequencing analyses.
[Cancer Research]
Lenkiewicz, E., Malasi, S., Hogenson, T. L., Flores, L. F., Barham, W., Phillips, W. J., Roesler, A. S., Chambers, K. R., Rajbhandari, N., Hayashi, A., Antal, C. E., Downes, M., Grandgenett, P. M., Hollingsworth, M. A., Cridebring, D., Xiong, Y., Lee, J.-H., Ye, Z., Yan, H., … Barrett, M. T. (2020). Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-0078 Cite
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Introduction of hsa-MiR-512-3p as a New Regulator of HER2 Signaling Pathway in Breast Cancer

Researchers found that miR-512-3p acted as a cell-type-specific tumor suppressor, through targeting HER2, HER3, PIK3R2, and AKT1 transcripts.
[Breast Cancer Research and Treatment]
Mohamadzade, Z., Mahjoubi, F., & Soltani, B. M. (2020). Introduction of hsa-miR-512-3p as a new regulator of HER2 signaling pathway in breast cancer. Breast Cancer Research and Treatment. https://doi.org/10.1007/s10549-020-05937-3 Cite
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LncRNA BCYRN1 Inhibits Glioma Tumorigenesis by Competitively Binding with miR-619-5p to Regulate CUEDC2 Expression and the PTEN/AKT/p21 Pathway

Three fresh tumor tissues from glioma patients and three normal brain tissues from craniocerebral trauma patients were prepared for high-throughput RNA sequencing.
[Oncogene]
Mu, M., Niu, W., Zhang, X., Hu, S., & Niu, C. (2020). LncRNA BCYRN1 inhibits glioma tumorigenesis by competitively binding with miR-619-5p to regulate CUEDC2 expression and the PTEN/AKT/p21 pathway. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01466-x Cite
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Immune Cell Composition in Normal Human Kidneys

Normal human kidneys were obtained from radically nephrectomised patients with urogenital malignancy. Subsequently, human kidney immune cell subsets were analysed using multicolor flow cytometry and compared with subsets from C57BL/6 or BALB/c mice under specific pathogen-free conditions.
[Scientific Reports]
Park, J.-G., Na, M., Kim, M.-G., Park, S. H., Lee, H. J., Kim, D. K., Kwak, C., Kim, Y. S., Chang, S., Moon, K. C., Lee, D.-S., & Han, S. S. (2020). Immune cell composition in normal human kidneys. Scientific Reports, 10(1), 15678. https://doi.org/10.1038/s41598-020-72821-x Cite
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BCAS2, a Protein Enriched in Advanced Prostate Cancer, Interacts with NBS1 to Enhance DNA Double-Strand Break Repair

Western blotting and immunofluorescence microscopy were used to assay the roles of breast cancer amplified sequence 2 (BCAS2) in the double-strand breaks of prostate cancer cells and apoptosis in Drosophila, respectively.
[British Journal of Cancer]
Wang, L.-P., Chen, T.-Y., Kang, C.-K., Huang, H.-P., & Chen, S.-L. (2020). BCAS2, a protein enriched in advanced prostate cancer, interacts with NBS1 to enhance DNA double-strand break repair. British Journal of Cancer, 1–12. https://doi.org/10.1038/s41416-020-01086-y Cite
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microRNA-130b-3p Contained in Mesenchymal Stem Cell-Derived Extracellular Vesicles Promotes Lung Cancer Progression by Regulating the FOXO3/NFE2L2/TXNRD1 Axis

A tumor xenograft mouse model was used to determine role of extracellular vesicles-microRNA-130b-3p and its target FOXO3 in lung cancer progression in vivo.
[Molecular Therapy-Oncolytics]
Guo, Q., Yan, J., Song, T., Zhong, C., Kuang, J., Mo, Y., Tan, J., Li, D., Sui, Z., Cai, K., & Zhang, J. (2020). microRNA-130b-3p Contained in Mesenchymal Stem Cell-Derived Extracellular Vesicles Promotes Lung Cancer Progression by Regulating the FOXO3/NFE2L2/TXNRD1 Axis. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2020.09.005 Cite
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Nitidine Chloride Possesses Anticancer Property in Lung Cancer Cells through Activating Hippo Signaling Pathway

The authors investigated the anti-tumor functions and the feasible molecular basis of nitidine chloride in NSCLC cells.
[Cell Death Discovery]
Zhang, J., Wu, L., Lian, C., Lian, S., Bao, S., Zhang, J., Wang, P., Ma, J., & Li, Y. (2020). Nitidine chloride possesses anticancer property in lung cancer cells through activating Hippo signaling pathway. Cell Death Discovery, 6(1), 1–9. https://doi.org/10.1038/s41420-020-00326-7 Cite
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IMP3 Accelerates the Progression of Prostate Cancer through Inhibiting PTEN Expression in a SMURF1-Dependent Way

Insulin-like growth factor 2 messenger RNA binding protein 3 expression level was significantly increased in prostate cancer tissues and cell lines as compared with the paracancerous normal tissues and cells.
[Journal of Experimental & Clinical Cancer Research]
Zhang, X., Wang, D., Liu, B., Jin, X., Wang, X., Pan, J., Tu, W., & Shao, Y. (2020). IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way. Journal of Experimental & Clinical Cancer Research, 39(1), 190. https://doi.org/10.1186/s13046-020-01657-0 Cite
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Breast Cancer Cell Detection and Characterization From Breast Milk-Derived Cells

Using the recently established culturing method that allowed propagation of normal and cancerous breast epithelial cells of luminal origin, flow cytometry characterization, and genomic sequencing, scientists showed that cancer cells were detected in breast milk.
[Cancer Research]
Bhat-Nakshatri, P., Kumar, B., Simpson, E., Ludwig, K. K., Cox, M. L., Gao, H., Liu, Y., & Nakshatri, H. (2020). Breast cancer cell detection and characterization from breast milk-derived cells. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-1030 Cite
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Transcriptional Repression of p21 by EIF1AX Promotes the Proliferation of Breast Cancer Cells

A mechanistic investigation showed that EIF1AX inhibited the expression of p21, which is an essential cell cycle regulator.
[Cell Proliferation]
Li, Y., Guo, L., Ying, S., Feng, G.-H., & Zhang, Y. (n.d.). Transcriptional repression of p21 by EIF1AX promotes the proliferation of breast cancer cells. Cell Proliferation, n/a(n/a), e12903. https://doi.org/10.1111/cpr.12903 Cite
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