Long Non-Coding RNA MIR503HG Inhibits the Proliferation, Migration and Invasion of Colon Cancer Cells via MiR-107/Par4 Axis

MIR503HG negatively regulated its target miR-107. MiR-107 overexpression reversed the anti-tumor effects of MIR503HG overexpression on colon cancer cells. Par4 was a target of miR-107, which was positively regulated by MIR503HG. The promoting effects of MIR503HG silencing on colon cancer cells were eliminated by Par4 overexpression.
[Experimental Cell Research]
Han, H., Li, H., & Zhou, J. (2020). Long non-coding RNA MIR503HG inhibits the proliferation, migration and invasion of colon cancer cells via miR-107/Par4 axis. Experimental Cell Research, 395(2), 112205. https://doi.org/10.1016/j.yexcr.2020.112205 Cite
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Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells

The nanocomplexes formed by metallodendrimers and different siRNA were examined for their zeta potential and size, and by transmission electron microscopy, fluorescence polarisation, circular dichroism, and electrophoresis. The internalisation of dendriplexes was estimated by flow cytometry and confocal microscopy in a human breast cancer cell line, following the ability of these metallodendrimers to deliver the siRNA into the cell. In vitro cell viability experiments have indicated effective interactions between Cu (II) dendrimers and pro-apoptotic siRNAs: Mcl-1 and Bcl-2 in breast cancer cells.
[Pharmaceutics]
Sanz del Olmo, N., Holota, M., Michlewska, S., Gómez, R., Ortega, P., Ionov, M., de la Mata, F. J., & Bryszewska, M. (2020). Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells. Pharmaceutics, 12(8), 727. https://doi.org/10.3390/pharmaceutics12080727 Cite
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Elevation in the Counts of IL-35-Producing B Cells Infiltrating into Lung Tissue in Mycobacterial Infection Is Associated with the Downregulation of Th1/Th17 and Upregulation of Foxp3+Treg

Purified B cells from such patients generated more IL-35 after stimulation by antigens of Mycobacterium tuberculosis and secreted more IL-10.
[Scientific Reports]
Chen, C., Xu, H., Peng, Y., Luo, H., Huang, G.-X., Wu, X.-J., Dai, Y.-C., Luo, H.-L., Zhang, J.-A., Zheng, B.-Y., Zhang, X.-N., Chen, Z. W., & Xu, J.-F. (2020). Elevation in the counts of IL-35-producing B cells infiltrating into lung tissue in mycobacterial infection is associated with the downregulation of Th1/Th17 and upregulation of Foxp3 + Treg. Scientific Reports, 10(1), 13212. https://doi.org/10.1038/s41598-020-69984-y Cite
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A Lung Tropic AAV Vector Improves Survival in a Mouse Model of Surfactant B Deficiency

Scientists report a rationally designed adeno-associated virus 6 capsid that demonstrates efficiency in lung epithelial cell transduction based on imaging and flow cytometry analysis.
[Nature Communications]
Kang, M. H., van Lieshout, L. P., Xu, L., Domm, J. M., Vadivel, A., Renesme, L., Mühlfeld, C., Hurskainen, M., Mižíková, I., Pei, Y., van Vloten, J. P., Thomas, S. P., Milazzo, C., Cyr-Depauw, C., Whitsett, J. A., Nogee, L. M., Wootton, S. K., & Thébaud, B. (2020). A lung tropic AAV vector improves survival in a mouse model of surfactant B deficiency. Nature Communications, 11(1), 3929. https://doi.org/10.1038/s41467-020-17577-8 Cite
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Polydatin Executes Anticancer Effects against Glioblastoma Multiforme by Inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail Signaling Pathway

The authors demonstrated that polydatin repressed cell proliferation, migration, invasion and stemness and promoted apoptosis in glioblastoma multiforme cells.
[Life Sciences]
Chen, Y., Niu, J., Li, L., Li, Z., Jiang, J., Zhu, M., Dong, T., Zhang, J., Shi, C., Xu, P., Lu, Y., Jiang, Y., Liu, P., & Chen, W. (2020). Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail signaling pathway. Life Sciences, 118158. https://doi.org/10.1016/j.lfs.2020.118158 Cite
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Dental Follicle Stem Cells Rescue the Regenerative Capacity of Inflamed Rat Dental Pulp through a Paracrine Pathway

Researchers focused on the paracrine effects of rat dental follicle stem cells (DFSCs) on the inflammation and regeneration of rat injured dental pulp to detect whether DFSCs are a potential candidate for mesenchymal stem cell-based minimally invasive vital pulp therapy.
[Stem Cell Research & Therapy]
Hong, H., Chen, X., Li, K., Wang, N., Li, M., Yang, B., Yu, X., & Wei, X. (2020). Dental follicle stem cells rescue the regenerative capacity of inflamed rat dental pulp through a paracrine pathway. Stem Cell Research & Therapy, 11(1), 333. https://doi.org/10.1186/s13287-020-01841-1 Cite
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Suppressive Myeloid Cells Are Expanded by Biliary Tract Cancer-Derived Cytokines In Vitro and Associate with Aggressive Disease

Activated signaling pathways and cytokine production were evaluated in a panel of human biliary tract cancer (BTC) cell lines. Human peripheral blood mononuclear cells were cultured with BTC supernatants, with and without cytokine neutralising antibodies, and analysed by flow cytometry or immunoblot.
[British Journal of Cancer]
Ware, M. B., Zaidi, M. Y., Yang, J., Turgeon, M. K., Krasinskas, A., Mace, T. A., Keenan, K., Farren, M. R., Ruggieri, A. N., Li, Y., Zhang, C., Chen, Z., Young, G. S., Elnaggar, O., Che, Z., Maithel, S. K., Bekaii-Saab, T., El-Rayes, B., & Lesinski, G. B. (2020). Suppressive myeloid cells are expanded by biliary tract cancer-derived cytokines in vitro and associate with aggressive disease. British Journal of Cancer, 1–10. https://doi.org/10.1038/s41416-020-1018-0 Cite
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Using Iron Sucrose-Labeled Adipose-Derived Mesenchymal Stem Cells in 1.5 and 3 T MRI Tracking: An In Vitro Study

Iron sucrose-labeled adipose-derived mesenchymal stem cells were tracked using T2-and T2∗-weighted sequences by 1.5 and 3 T MRI in an in vitro model.
[Heliyon]
Tangchitphisut, P., Srikaew, N., Phongkitkarun, S., Jaovisidha, S., & Tawonsawatruk, T. (2020). Using iron sucrose-labeled adipose-derived mesenchymal stem cells in 1.5 and 3 T MRI tracking: An in vitro study. Heliyon, 6(8). https://doi.org/10.1016/j.heliyon.2020.e04582 Cite
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Overexpression of miR-382 Sensitizes Hepatocellular Carcinoma Cells to γδ T Cells through Inhibiting the Expression of C-Flip

As miR-382 was observed to be downregulated in hepatocellular carcinoma (HCC) tissues and cell lines, researchers found that overexpression of miR-382 increased the sensitivity of HCC cells to γδ T cells.
[Molecular Therapy-Oncolytics]
Chen, Z., Zheng, Z., Feng, L., Huo, Z., Huang, L., Fu, M., Chen, Q., Ke, Y., Yang, J., & Hou, B. (2020). Overexpression of miR-382 sensitizes hepatocellular carcinoma cells to γδ T cells through inhibiting the expression of c-FLIP. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2020.07.012 Cite
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Human Ex Vivo Spinal Cord Slice Culture as a Useful Model of Neural Development, Lesion, and Allogeneic Neural Cell Therapy

Scientists applied experimental allogeneic human neural cell therapy after injury in ex vivo spinal cord slices.
[Stem Cell Research & Therapy]
Lin, C., Calzarossa, C., Fernandez-Zafra, T., Liu, J., Li, X., Ekblad-Nordberg, Å., Vazquez-Juarez, E., Codeluppi, S., Holmberg, L., Lindskog, M., Uhlén, P., & Åkesson, E. (2020). Human ex vivo spinal cord slice culture as a useful model of neural development, lesion, and allogeneic neural cell therapy. Stem Cell Research & Therapy, 11(1), 320. https://doi.org/10.1186/s13287-020-01771-y Cite
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MSCs-Released TGFβ1 Generate CD4+CD25+Foxp3+ in T-Reg Cells of Human SLE PBMC

The authors used a post-test control group design. MSCs were obtained from human umbilical cord blood and characterized according to their surface antigen expression and multilineage differentiation capacities.
[Journal of the Formosan Medical Association]
Darlan, D. M., Munir, D., Putra, A., & Jusuf, N. K. (2020). MSCs-released TGFβ1 generate CD4+CD25+Foxp3+ in T-reg cells of human SLE PBMC. Journal of the Formosan Medical Association. https://doi.org/10.1016/j.jfma.2020.06.028 Cite
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Progesterone Receptor Membrane Component 1 Promotes the Growth of Breast Cancers by Altering the Phosphoproteome and Augmenting EGFR/PI3K/AKT Signalling

Investigators demonstrated that progesterone receptor membrane component 1 played a prominent role in regulating the growth of cancer cells by altering the PI3K/AKT/mTOR and EGFR signalling mechanisms in both ER-positive and TNBC cells.
[British Journal of Cancer]
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