Molecular Subtype-Specific Responses of Colon Cancer Cells to the SMAC Mimetic Birinapant

Responses to the inhibitor of apoptosis protein antagonist Birinapant and oxaliplatin/5-fluorouracil were investigated in 14 colon cancer cell lines, representing the consensus molecular subtypes.
[Cell Death & Disease]
Fichtner, M., Bozkurt, E., Salvucci, M., McCann, C., McAllister, K. A., Halang, L., Düssmann, H., Kinsella, S., Crawford, N., Sessler, T., Longley, D. B., & Prehn, J. H. M. (2020). Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant. Cell Death & Disease, 11(11), 1–16. https://doi.org/10.1038/s41419-020-03232-z Cite
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In Silico and In Vitro Studies on the Anti-Cancer Activity of Andrographolide Targeting Survivin in Human Breast Cancer Stem Cells

Human CD24/CD44+ breast cancer stem cells (BCSCs) were treated with andrographolide in vitro for 24 hours. The cytotoxic effect of andrographolide on BCSCs was compared to that on human mesenchymal stem cells.
[PLoS One]
Wanandi, S. I., Limanto, A., Yunita, E., Syahrani, R. A., Louisa, M., Wibowo, A. E., & Arumsari, S. (2020). In silico and in vitro studies on the anti-cancer activity of andrographolide targeting survivin in human breast cancer stem cells. PLOS ONE, 15(11), e0240020. https://doi.org/10.1371/journal.pone.0240020 Cite
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USP7, Negatively Regulated by miR‐409‐5p, Aggravates Hypoxia‐Induced Cardiomyocyte Injury

The authors investigated the role and the underlying regulatory mechanism of ubiquitin specific peptidase 7 (USP7) in myocardial infarction.
[APMIS]
Xue, Q., Yang, D., Zhang, J., Gan, P., Lin, C., Lu, Y., Zhang, W., Zhang, L., & Guang, X. (n.d.). USP7, negatively regulated by miR-409-5p, aggravates hypoxia-induced cardiomyocyte injury. APMIS, n/a(n/a). https://doi.org/https://doi.org/10.1111/apm.13100 Cite
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High-Dose per Fraction Radiotherapy Induces Both Anti-Tumor Immunity and Immunosuppressive Responses in Prostate Tumors

Scientists studied the effects of high-dose per fraction radiotherapy with and without anti-Gr-1 using syngeneic murine allograft prostate cancer models. The dynamic change of immune populations, including tumor-infiltrating lymphocytes, T-regulatory cells, and myeloid-derived suppressive cells was evaluated using flow cytometry and immunohistochemistry.
[Clinical Cancer Research]
High-Dose per Fraction Radiotherapy Induces Both Anti-Tumor Immunity and Immunosuppressive Responses in Prostate Tumors | Clinical Cancer Research. (n.d.). Retrieved November 24, 2020, from https://clincancerres.aacrjournals.org/content/early/2020/11/20/1078-0432.CCR-20-2293 Cite
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Type I Interferons Drive the Maturation of Human DC3s with a Distinct Costimulatory Profile Characterized by High GITRL

Researchers used multiparameter flow cytometry and CITE-sequencing to investigate the cell type–specific responses of human peripheral blood dendritic cells and monocyte subsets to type I interferons, focusing on differential regulation of costimulatory molecules.
[Science Immunology]
Type I interferons drive the maturation of human DC3s with a distinct costimulatory profile characterized by high GITRL | Science Immunology. (n.d.). Retrieved November 24, 2020, from https://immunology.sciencemag.org/content/5/53/eabe0347 Cite
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The Tumor Suppressor Zinc Finger Protein 471 Suppresses Breast Cancer Growth and Metastasis through Inhibiting AKT and Wnt/β-Catenin Signaling

Scientists studied Zinc-finger protein 471 expression, functions, and molecular mechanisms in breast cancer.
[Clinical Epigenetics]
The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling | Clinical Epigenetics | Full Text. (n.d.). Retrieved November 23, 2020, from https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-020-00959-6 Cite
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Role of Fibrocytes and Endothelial ProgenitoPr Cells among Low-Differentiated CD34+ Cells in the Progression of Lung Sarcoidosis

Scientists characterized of the CD34+ cell population in peripheral blood in patients with sarcoidosis (SA) with reference to the control group. Moreover in patients with SA, fibrocytes and endothelial cells were analyzed and their relationship to the fibrosis process based on assessment of diffusing capacity for carbon monoxide.
[BMC Pulmonary Medicine]
Elżbieta, R., Iwona, K., Joanna, B., Karina, J.-R., & Piotr, R. (2020). Role of fibrocytes and endothelial progenitor cells among low-differentiated CD34+ cells in the progression of lung sarcoidosis. BMC Pulmonary Medicine, 20(1), 306. https://doi.org/10.1186/s12890-020-01345-x Cite
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Skeletal Muscle Healing by M1-Like Macrophages Produced by Transient Expression of Exogenous GM-CSF

Increasing the number of M1-like macrophages immediately after traumatic muscle injury promoted muscle recovery with less fibrosis, and this can be achieved by the transient expression of granulocyte and monocyte colony stimulating factor (GM-CSF).
[Stem Cell Research & Therapy]
Martins, L., Gallo, C. C., Honda, T. S. B., Alves, P. T., Stilhano, R. S., Rosa, D. S., Koh, T. J., & Han, S. W. (2020). Skeletal muscle healing by M1-like macrophages produced by transient expression of exogenous GM-CSF. Stem Cell Research & Therapy, 11(1), 473. https://doi.org/10.1186/s13287-020-01992-1 Cite
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PDGF Mediates Pulmonary Arterial Smooth Muscle Cell Proliferation and Migration by Regulating NFATc2

Researchers investigated whether platelet‑derived growth factor (PDGF) affects the proliferation and migration of pulmonary arterial smooth muscle cells by regulating nuclear factor of activated T cell (NFAT), and to study the pathogenesis of pulmonary arterial hypertension.
[Molecular Medicine Reports]
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HPLC Phenolic Profile and Induction of Apoptosis by Linum Usitatissimum Extract in LNCaP Cells by Caspase3 and Bax Pathways

Researchers reported the phenolic and flavonoid constituents, antioxidant activity, and potential of the L. usitatissimum plant extract against prostate cancer cells. The phenolic and flavonoid compound profile of the extract were established using HPLC analysis.
[AMB Express]
Zhou, X., Huang, N., Chen, W., Xiaoling, T., Mahdavi, B., Raoofi, A., Mahdian, D., & Atabati, H. (2020). HPLC phenolic profile and induction of apoptosis by Linum usitatissimum extract in LNCaP cells by caspase3 and Bax pathways. AMB Express, 10(1), 203. https://doi.org/10.1186/s13568-020-01138-9 Cite
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The Effect of Vascular Complications of Diabetes Mellitus on Human Umbilical Cord Tissue and the Number of Wharton Jelly’s Mesenchymal Stem Cells

The umbilical cords were investigated by the histomorphological method and the number of Wharton’s jelly (WJ)-MSC were detected by flow-cytometry using the CD90, CD44, CD105, and CD73 markers in WJ isolated from fresh umbilical cords.
[Molecular Biology Reports]
Karaca, C., Bostancıeri, N., Ovayolu, A., & Kahraman, D. T. (2020). The effect of vascular complications of diabetes mellitus on human umbilical cord tissue and the number of Wharton Jelly’s mesenchymal stem cells. Molecular Biology Reports. https://doi.org/10.1007/s11033-020-05965-8 Cite
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