Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin

Scientists demonstrated that salinomycin displayed potent anti-fibrotic activity in cardiac fibroblasts obtained from heart failure patients. In pre-clinical studies, salinomycin prevented cardiac fibrosis and functional decline in mouse models of ischemic and non-ischemic heart disease.
[Circulation Research]
Burke Ryan M, Dirkx, Jr. R. A., Quijada Pearl, Lighthouse Janet K, Mohan Amy, O’Brien Meghann, Wojciechowski Wojciech, Woeller Collynn, Phipps Richard P, Alexis Jeffrey D, Ashton John, & Small Eric M. (n.d.). Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.120.317791 Cite
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Bioengineering of the Digestive Tract: Approaching the Clinic

Scientists succinctly illustrate the three technologies that are closer to clinical translation—namely, human intestinal organoids, sphincter bioengineering and decellularization
[Cytotherapy]
Speer, A. L., Ren, X., McNeill, E. P., Aziz, J. M., Muir, S. M., Marino, D. I., Dadhich, P., Sawant, K., Ciccocioppo, R., Asthana, A., Bitar, K. N., & Orlando, G. (2021). Bioengineering of the digestive tract: approaching the clinic. Cytotherapy. https://doi.org/10.1016/j.jcyt.2021.02.006 Cite
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Understanding the Cellular Origin and Progression of Esophageal Cancer Using Esophageal Organoids

Patient-derived organoids (PDOs) from human tissue samples allow for unique and faithful in vitro modeling of esophageal cancers, and provide an exciting platform for investigation into personalized medicine and targeted treatment approaches
[Cancer Letters]
Sachdeva, U. M., Shimonosono, M., Flashner, S., Cruz-Acuña, R., Gabre, J. T., & Nakagawa, H. (2021). Understanding the cellular origin and progression of esophageal cancer using esophageal organoids. Cancer Letters. https://doi.org/10.1016/j.canlet.2021.03.031 Cite
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Complement Factor I Upregulates Expression of Matrix Metalloproteinase‐13 and ‐2 and Promotes Invasion of Cutaneous Squamous Carcinoma Cells

The authors studied the functional role of complement factor I (CFI) in the progression of cutaneous squamous cell carcinoma (cSCC). CFI was knocked down in cSCC cells and RNA‐seq analysis was performed.
[Experimental Dermatology]
Nezhad, P. R., Riihilä, P., Piipponen, M., Kallajoki, M., Meri, S., Nissinen, L., & Kähäri, V.-M. (n.d.). Complement Factor I upregulates expression of matrix metalloproteinase-13 and -2 and promotes invasion of cutaneous squamous carcinoma cells. Experimental Dermatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/exd.14349 Cite
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Exosome-Delivered CD44v6/C1QBP Complex Drives Pancreatic Cancer Liver Metastasis by Promoting Fibrotic Liver Microenvironment

Researchers explored the underlying mechanisms of how pancreatic ductal adenocarcinoma-derived exosomes modulate the liver microenvironment and promote metastasis.
[Pancreas]
Xie, Z., Gao, Y., Ho, C., Li, L., Jin, C., Wang, X., Zou, C., Mao, Y., Wang, X., Li, Q., Fu, D., & Zhang, Y.-F. (2021). Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment. Gut. https://doi.org/10.1136/gutjnl-2020-323014 Cite
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CARD10 Cleavage by MALT1 Restricts Lung Carcinoma Growth In Vivo

Preventing CARD10 cleavage in the lung tumor A549 cell line increased basal levels of IL-6 and extracellular matrix components in vitro.
[Oncogenesis]
Israël, L., Glück, A., Berger, M., Coral, M., Ceci, M., Unterreiner, A., Rubert, J., Bardet, M., Ginster, S., Golding-Ochsenbein, A. M., Martin, K., Hoyler, T., Calzascia, T., Wieczorek, G., Hillenbrand, R., Ferretti, S., Ferrero, E., & Bornancin, F. (2021). CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo. Oncogenesis, 10(4), 1–11. https://doi.org/10.1038/s41389-021-00321-2 Cite
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Electrokinetic Perfusion through 3D Culture Reduces Cell Mortality

Researchers compared the efficacy of pressure driven perfusion with electrokinetic perfusion toward reducing cell mortality in 3D cultures of Matrigel extracellular matrix.
[Tissue Engineering Part A]
Sarkar, A., & Messerli, M. (2021). Electrokinetic Perfusion Through 3D Culture Reduces Cell Mortality. Tissue Engineering Part A. https://doi.org/10.1089/ten.TEA.2021.0008 Cite
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KRAS Mutant Rectal Cancer Cells Interact with Surrounding Fibroblasts to Deplete the Extracellular Matrix

Scientists found that KRAS‐mutant tumors displayed lower expression of genes related to the tumor stroma and remodeling of the extracellular matrix.
[Molecular Oncology]
Kim, J. K., Marco, M. R., Choi, S.-H., Qu, X., Chen, C.-T., Elkabets, M., Fairchild, L., Chow, O., Barriga, F. M., Dow, L. E., O’Rourke, K., Szeglin, B., Yarilin, D., Fujisawa, S., Manova‐Todorova, K., Paty, P. B., Shia, J., Leslie, C., Smith, J. J., … Garcia‐Aguilar, J. (n.d.). KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix. Molecular Oncology, n/a(n/a). https://doi.org/https://doi.org/10.1002/1878-0261.12960 Cite
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Insulin-Positive Ductal Cells Do Not Migrate Into Preexisting Islets during Pregnancy

Researchers used a cell-tagging dye, CFDA-SE, to permanently label pancreatic duct cells through an intraductal infusion technique.
[Experimental and Molecular Medicine]
Liu, Q., Jiang, Y., Zhu, L., Qian, J., Wang, C., Yang, T., Prasadan, K., Gittes, G. K., & Xiao, X. (2021). Insulin-positive ductal cells do not migrate into preexisting islets during pregnancy. Experimental & Molecular Medicine, 1–10. https://doi.org/10.1038/s12276-021-00593-z Cite
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Coordinated Interactions between Endothelial Cells and Macrophages in the Islet Microenvironment Promote β Cell Regeneration

The authors showed that proliferative endothelial cells modulated macrophage (MΦ) infiltration and phenotype during β cell loss, and recruited MΦs were essential for β cell recovery.
[npj Regenerative Medicine]
Saunders, D. C., Aamodt, K. I., Richardson, T. M., Hopkirk, A. J., Aramandla, R., Poffenberger, G., Jenkins, R., Flaherty, D. K., Prasad, N., Levy, S. E., Powers, A. C., & Brissova, M. (2021). Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote β cell regeneration. Npj Regenerative Medicine, 6(1), 1–13. https://doi.org/10.1038/s41536-021-00129-z Cite
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Three-Dimensional Human Neural Stem Cell Models to Mimic Heparan Sulfate Proteoglycans and the Neural Niche

This review examines the current knowledge of heparan sulfate proteoglycans in the stem cell niche, human stem cell models, and their role in the development of 3D models that mimic the in vivo neural extracellular matrix.
[Seminars in Thrombosis and Hemostasis]
Peall, I. W., Okolicsanyi, R. K., Griffiths, L. R., & Haupt, L. M. (2021). Three-Dimensional Human Neural Stem Cell Models to Mimic Heparan Sulfate Proteoglycans and the Neural Niche. Seminars in Thrombosis and Hemostasis, 47(03), 308–315. https://doi.org/10.1055/s-0041-1724117 Cite
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