Tag Archives: extracellular matrix

Transcriptomic Profile of Pea3 Family Members Reveal Regulatory Codes for Axon Outgrowth and Neuronal Connection Specificity

Using transcriptomics and qPCR analyses in SH-SY5Y neuroblastoma cells, hypothalamic and hippocampal cell line, scientists identified cell type-specific and subfamily member-specific targets for PEA3 transcription factor subfamily.
[Scientific Reports]
Kandemir, B., Gulfidan, G., Arga, K. Y., Yilmaz, B., & Kurnaz, I. A. (2020). Transcriptomic profile of Pea3 family members reveal regulatory codes for axon outgrowth and neuronal connection specificity. Scientific Reports, 10(1), 18162. https://doi.org/10.1038/s41598-020-75089-3 Cite
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Escherichia coli Foster Bladder Cancer Cell Line Progression via Epithelial Mesenchymal Transition, Stemness and Metabolic Reprogramming

In vitro infection of the T24 cell line with E. coli was performed to study the bacterial impact on bladder cancer cells. EMT markers were assessed using immunohistochemistry, western blot and RT-PCR. Stemness characteristics were monitored using RT-PCR.
[Scientific Reports]
Abd-El-Raouf, R., Ouf, S. A., Gabr, M. M., Zakaria, M. M., El-Yasergy, K. F., & Ali-El-Dein, B. (2020). Escherichia coli foster bladder cancer cell line progression via epithelial mesenchymal transition, stemness and metabolic reprogramming. Scientific Reports, 10(1), 18024. https://doi.org/10.1038/s41598-020-74390-5 Cite
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Extracellular Matrix Plasticity as a Driver of Cell Spreading

Scientists demonstrated that network plasticity independently controls mesenchymal stem cell spreading through a biphasic relationship dependent on cell-intrinsic forces, and this relationship can be shifted by inhibiting actomyosin contractility.
[Proceedings of the National Academy of Sciences of the United States of America]
Grolman, J. M., Weinand, P., & Mooney, D. J. (2020). Extracellular matrix plasticity as a driver of cell spreading. Proceedings of the National Academy of Sciences, 117(42), 25999–26007. https://doi.org/10.1073/pnas.2008801117 Cite
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Identification of Drivers of Breast Cancer Invasion by Secretome Analysis: Insight Into CTGF Signaling

Scientists combined data from secretome and proteome analysis using mass spectrometry with microarray data from mesenchymal transformed breast cancer cells to elucidate the drivers of epithelial-mesenchymal transition and cell invasion.
[Scientific Reports]
Identification of drivers of breast cancer invasion by secretome analysis: insight into CTGF signaling | Scientific Reports. (n.d.). Retrieved October 21, 2020, from https://www.nature.com/articles/s41598-020-74838-8 Cite
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Decellularized Extracellular Matrix Scaffolds Identify Full-Length Collagen VI as a Driver of Breast Cancer Cell Invasion in Obesity and Metastasis

The authors describe a method to study whole-tissue extracellular matrix (ECM) effects from disease states associated with metastasis on tumor cell phenotypes and identified the individual ECM proteins and signaling pathways that were driving these effects. They showed that decellularized ECM from tumor-bearing and obese mammary glands drives TNBC cell invasion.
[Science Advances]
Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis | Science Advances. (n.d.). Retrieved October 21, 2020, from https://advances.sciencemag.org/content/6/43/eabc3175 Cite
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Ziyuglycoside II Alleviates Cyclophosphamide-Induced Leukopenia in Mice via Regulation of HSPC Proliferation and Differentiation

The authors investigated the pro-hematopoietic effects and underlying mechanisms of ziyuglycoside II in cyclophosphamide-induced leukopenia in mice.
[Biomedicine & Pharmacotherapy]
Fang, H., Xie, X., Liu, P., Rao, Y., Cui, Y., Yang, S., Yu, J., Luo, Y., & Feng, Y. (2020). Ziyuglycoside II alleviates cyclophosphamide-induced leukopenia in mice via regulation of HSPC proliferation and differentiation. Biomedicine & Pharmacotherapy, 132, 110862. https://doi.org/10.1016/j.biopha.2020.110862 Cite
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Siah2 Integrates Mitogenic and Extracellular Matrix Signals Linking Neuronal Progenitor Ciliogenesis with Germinal Zone Occupancy

Researchers determined that the Siah2 E3 ubiquitin ligase functions in a coincidence detection circuit linking responses to the Shh mitogen and the ECM to control cerebellar granule neurons germinal zone occupancy.
[Nature Communications]
Ong, T., Trivedi, N., Wakefield, R., Frase, S., & Solecki, D. J. (2020). Siah2 integrates mitogenic and extracellular matrix signals linking neuronal progenitor ciliogenesis with germinal zone occupancy. Nature Communications, 11(1), 5312. https://doi.org/10.1038/s41467-020-19063-7 Cite
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Modeling the Interaction between the Microenvironment and Tumor Cells in Brain Tumors

The authors focus on brain microenvironment features impacted by tumor biology. They also discuss limits of current preclinical models and how complementary models, such as humanized animals and organoids, will allow deeper mechanistic insights on cancer biology, allowing for more efficient testing of therapeutic strategies, including immunotherapy, for brain cancers.
[Neuron]
Pasqualini, C., Kozaki, T., Bruschi, M., Nguyen, T. H. H., Minard-Colin, V., Castel, D., Grill, J., & Ginhoux, F. (2020). Modeling the Interaction between the Microenvironment and Tumor Cells in Brain Tumors. Neuron, 0(0). https://doi.org/10.1016/j.neuron.2020.09.018 Cite
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Exosome-Mediated Metabolic Reprogramming: The Emerging Role in Tumor Microenvironment Remodeling and Its Influence on Cancer Progression

The authors present the role of exosomes in the tumor microenvironment and the underlying mechanism of how exosomes exacerbate tumor development through metabolic reprogramming.
[Signal Transduction and Targeted Therapy]
Yang, E., Wang, X., Gong, Z., Yu, M., Wu, H., & Zhang, D. (2020). Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression. Signal Transduction and Targeted Therapy, 5(1), 1–13. https://doi.org/10.1038/s41392-020-00359-5 Cite
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ER-Resident Oxidoreductases Are Glycosylated and Trafficked to the Cell Surface to Promote Matrix Degradation by Tumor Cells

Investigators showed that GALA induced the glycosylation of the ER-resident calnexin (Cnx) in breast and liver cancer. Glycosylated Cnx and its partner ERp57 are trafficked to invadosomes, which are sites of ECM degradation.
[Nature Cell Biology]
Ros, M., Nguyen, A. T., Chia, J., Le Tran, S., Le Guezennec, X., McDowall, R., Vakhrushev, S., Clausen, H., Humphries, M. J., Saltel, F., & Bard, F. A. (2020). ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells. Nature Cell Biology, 1–11. https://doi.org/10.1038/s41556-020-00590-w Cite
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Tenascin C Promotes Cancer Cell Plasticity in Mesenchymal Glioblastoma

Researchers identified Tenascin C (TNC) to be upregulated and secreted in mesenchymal glioblastoma subtype with high NF-κB signaling activity. Silencing TNC decreased proliferation, migration and suppresses self-renewal of glioma stem cells.
[Oncogene]
Angel, I., Pilo Kerman, O., Rousso-Noori, L., & Friedmann-Morvinski, D. (2020). Tenascin C promotes cancer cell plasticity in mesenchymal glioblastoma. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-01506-6 Cite
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