Researchers report a method to generate a 3D motor neuron model with segregated and directed axonal outgrowth. iPSC-derived motor neurons were cultured in extracellular matrix gel in a microfluidic platform.
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An innovative rolled‐up impedimetric microfulidic sensor, called sensor‐in‐a‐tube, was introduced for the simultaneous analysis of single human monocytes CD14+ and their extracellular medium upon liposaccharides‐mediated activation.
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Egunov, A. I., Dou, Z., Karnaushenko, D. D., Hebenstreit, F., Kretschmann, N., Akgün, K., Ziemssen, T., Karnaushenko, D., Medina‐Sánchez, M., & Schmidt, O. G. (n.d.). Impedimetric Microfluidic Sensor-in-a-Tube for Label-Free Immune Cell Analysis. Small, n/a(n/a), 2002549. https://doi.org/https://doi.org/10.1002/smll.202002549 Cite
To fast-track translation of therapies and to inform personalised medicine, researchers aimed to develop a whole-tissue ex vivo explant model that maintains viability, 3D multicellular architecture, and microenvironmental cues of human pancreatic tumours.
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Kokkinos, J., Sharbeen, G., Haghighi, K. S., Ignacio, R. M. C., Kopecky, C., Gonzales-Aloy, E., Youkhana, J., Timpson, P., Pereira, B. A., Ritchie, S., Pandzic, E., Boyer, C., Davis, T. P., Butler, L. M., Goldstein, D., McCarroll, J. A., & Phillips, P. A. (2021). Ex vivo culture of intact human patient derived pancreatic tumour tissue. Scientific Reports, 11(1), 1944. https://doi.org/10.1038/s41598-021-81299-0 Cite
The authors report a generalizable strategy utilizing a photomediated oxime ligation to covalently decorate naturally derived hydrogels with bioactive proteins including growth factors.
[Proceedings of the National Academy of Sciences of the United States of America]
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Histogen Inc. announced that the US FDA has verbally notified the company that it has additional questions about the company’s Investigational New Drug application package for the planned Phase I/II clinical trial of HST-003, which is intended to evaluate the safety and efficacy of human ECM implanted within microfracture interstices and the cartilage defect in the knee to regenerate hyaline cartilage in combination with a microfracture procedure.
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The structural information of the insulin-like growth factor 2 receptor (IGF2R), an overexpressed protein on activated hepatic stellate cells, were used for an in silico screening of novel IGF2R-specific peptide ligands.
[Journal of Materials Chemistry B]
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Weber, F., Casalini, T., Valentino, G., Brülisauer, L., Andreas, N., Koeberle, A., Kamradt, T., Contini, A., & Luciani, P. (2021). Targeting transdifferentiated hepatic stellate cells and monitoring the hepatic fibrogenic process by means of IGF2R-specific peptides designed in silico. Journal of Materials Chemistry B. https://doi.org/10.1039/D0TB02372H Cite
The authors demonstrate a robust and simple approach to form collagen substrates with different topographies by evaporating droplets of a collagen solution.
Overexpression of decorin in inflammatory breast cancer (IBC) cells markedly decreased migration, invasion, and cancer stem cells in vitro and inhibited tumor growth and metastasis in IBC xenograft mouse models.
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Hu, X., Villodre, E. S., Larson, R., Rahal, O. M., Wang, X., Gong, Y., Song, J., Krishnamurthy, S., Ueno, N. T., Tripathy, D., Woodward, W. A., & Debeb, B. G. (2021). Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer. Communications Biology, 4(1), 1–14. https://doi.org/10.1038/s42003-020-01590-0 Cite
Hyaluronan synthase 2 was strongly expressed in endothelial progenitor cells in the thickened intima. Moyamoya disease lesions showed minimal staining for chondroitin sulfate and hyaluronan in the endothelium, in contrast to control endothelium showing positive staining for both.
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Matsuo, M., Nadanaka, S., Soga, M., Sugiyama, T., Serigano, S., Shimano, K., Ichinose, F., Nakamura, T., Maeda, T., Houkin, K., Era, T., & Kitagawa, H. (2021). Vulnerability to shear stress caused by altered peri-endothelial matrix is a key feature of Moyamoya disease. Scientific Reports, 11(1), 1552. https://doi.org/10.1038/s41598-021-81282-9 Cite
Nature uses ECM scaffolds to organize biominerals into hierarchical structures over various length scales. This has inspired the design of biomimetic mineralization scaffolds, with DNA nanostructures being among the most promising. DNA nanotechnology makes use of molecular recognition to controllably give 1D, 2D and 3D nanostructures.
[Nature Reviews Chemistry]
Scientists examine the current knowledge of integrins’ role in breast cancer.
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Yousefi, H., Vatanmakanian, M., Mahdiannasser, M., Mashouri, L., Alahari, N. V., Monjezi, M. R., Ilbeigi, S., & Alahari, S. K. (2021). Understanding the role of integrins in breast cancer invasion, metastasis, angiogenesis, and drug resistance. Oncogene, 1–21. https://doi.org/10.1038/s41388-020-01588-2 Cite