Researchers developed a translational protein engineering–based approach to reduce the dose and thereby improve the safety of rhBMP-2 delivered in a collagen sponge, as in InFUSE Bone Graft.
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In this review, the authors focus upon the microfibrillar collagen VI, which is present in the extracellular matrix of most tissues.
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Williams, L., Layton, T., Yang, N., Feldmann, M., & Nanchahal, J. (n.d.). Collagen VI as a driver and disease biomarker in human fibrosis. The FEBS Journal, n/a(n/a). https://doi.org/https://doi.org/10.1111/febs.16039 Cite
Scientists summarize the enormous amounts of findings on the signals mediating crosstalk of cancer-associated fibroblasts with cancer cells and its related targets or trials.
[Signal Transduction and Targeted Therapy]
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The authors hypothesized that stiffening of the airway ECM is a core pathological change sufficient to support excessive bronchoconstriction even in the absence of inflammation.
[Journal of Applied Psychology]
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Sphere Fluidics Limited and ClexBio has announced the launch of the biocompatible CYTRIX Microfluidic Hydrogel Kit. This kit allows researchers to study valuable cells over many weeks rather than days in defined microenvironments that mimic the natural ECM.
[Sphere Fluidics Limited]
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Compared to normal mammary gland tissues, cross-linked hyaluronan levels were significantly decreased in breast cancer and associated with tumor malignancy.
[Cell Death & Disease]
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Investigators discovered that vitronectin promoted collagen fibril formation and inhibited cathepsin K activity, and observed its activation in vitro.
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RNA-sequencing analysis of zymosan-treated MSCs showed that calcineurin-NFAT inhibition affects extracellular matrix genes, but not cytokine expression that is under the control of the NF-κB pathway.
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Investigators reported a vapor-phased fabrication process for constructing 3D modulated scaffold materials via simple steps based on controlling mass transport of vapor sublimation and deposition.
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Marine macroalgae species Ulva sp. and Cladophora sp. were selected for their structural variations, porous and fibrous respectively, and evaluated as alternative ECM candidates.
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The authors carried out high-throughput functional screening using impedancemetry, and identified five miRNAs with potential antiproliferative or chemosensitive effects on SW1353 chondrosarcoma cells.
[International Journal of Molecular Sciences]
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Veys, C., Benmoussa, A., Contentin, R., Duchemin, A., Brotin, E., Lafont, J. E., Saintigny, Y., Poulain, L., Denoyelle, C., Demoor, M., Legendre, F., & Galéra, P. (2021). Tumor Suppressive Role of miR-342-5p in Human Chondrosarcoma Cells and 3D Organoids. International Journal of Molecular Sciences, 22(11), 5590. https://doi.org/10.3390/ijms22115590 Cite