Brahma Safeguards Canalization of Cardiac Mesoderm Differentiation

Scientists showed that the BRG1/BRM-associated factor chromatin-remodeling complex ATPase gene Brm safeguarded cell identity during directed cardiogenesis of mouse ESCs.
[Nature]
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Inducing Somatic Cells into Pluripotent Stem Cells Is an Important Platform to Study the Mechanism of Early Embryonic Development

Scientists introduce the research advance of both somatic cell reprogramming and early embryonic development, indicating that the mechanisms of iPSCs also shares common features with that of early embryonic development in several aspects.
[Molecular Reproduction and Development]
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Haploidy in Somatic Cells Is Induced by Mature Oocytes in Mice

Investigators demonstrated that the replacement of meiotic spindles in mature metaphases II arrested oocytes with nuclei of somatic cells in the G0/G1 stage of cell cycle resulted in the formation of de novo spindles consisting of somatic homologous chromosomes comprising of single chromatids.
[Communications Biology]
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A Large Scale Mass Spectrometry-Based Histone Screening for Assessing Epigenetic Developmental Toxicity

Scientists developed a mass spectrometry-based proof-of-concept to assess a histone code screening assay capable of simultaneously detecting multiple hPTM-changes in human ESCs.
[Scientific Reports]
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Parallel Functional Assessment of m6A Sites in Human Endodermal Differentiation with Base Editor Screens

The authors developed an adenine base editor-based strategy to systematically identify functional m6A sites that controlled lineage decisions of human #ESCs.
[Nature Communications]
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YAP1 Regulates the Self-Organized Fate Patterning of hESC-Derived Gastruloids

Investigators interrogated the contribution of the Hippo signaling effector YAP1 to the formation of the three germ layers by analyzing human ESC-derived 2D-micropatterned gastruloids.
[Stem Cell Reports]
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Selective Elimination of Pluripotent Stem Cells by PIKfyve Specific Inhibitors

Scientists showed that PIKfyve inhibitors could selectively eliminate pluripotent embryonal carcinoma cells, ESCs, and iPSCs under conditions where differentiated cells remained viable.
[Stem Cell Reports]
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Expression of the Transcription Factor PU.1 Induces the Generation of Microglia-Like Cells in Human Cortical Organoids

The authors developed a method to generate functional microglia in human cortical organoids from human embryonic stem cells.
[Nature Communications]
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Transcriptional Programs Regulating Neuronal Differentiation Are Disrupted in DLG2 Knockout Human Embryonic Stem Cells and Enriched for Schizophrenia and Related Disorders Risk Variants

Scientists integrated human genetics with transcriptomic data from differentiation of human ESCs into cortical excitatory neurons.
[Nature Communications]
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Genome-Wide CRISPR Screen Identifies Puf60 as a Novel Stemness Gene of Mouse Embryonic Stem Cells

To study the mechanisms in ESC self-renewal, screening and identification of key genes maintaining ESC self-renewal were performed by a genome-wide CRISPR-Cas9 knockout virus library.
[Stem Cells and Development]
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Stem Cells at Odds with Telomere Maintenance and Protection

The authors discuss insights into telomere protection in ESCs versus somatic cells and summarize findings on telomerase regulation as a function of pluripotency.
[Trends in Cell Biology]
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