embryonic stem cells

[iScience] By applying an in vitro system enabling inducible gene expression control, investigators reported that moderate induction of transcriptionally active exogenous β-catenin in β-catenin null mouse ESCs promoted epiblast-like cell derivation in vitro.

[Stem Cells International] Scientists discovered that p57Kip2 (p57), a cyclin-dependent kinase inhibitor canonically inhibiting cell proliferation, played a role in suppressing the pluripotency state of mouse ESCs.

[Biochemical and Biophysical Research Communications] Researchers generated Sephs1 knockout ESCs and found that deficiency of SEPSH1 had little effect on pluripotency maintenance and proliferation.

[Stem Cell Research] The authors generated a Beta2-microglobulin (B2M) homozygous knockout somatic cell nuclear transfer-induced ESC line using CRISPR/Cas9-mediated gene targeting.

[International Journal of Biological Sciences] Efforts have been made to generate immune-escaping human embryonic stem cells where T cell immunity was evaded by defecting β-2-microglobulin, a common unit for human leukocyte antigen class I, and NK cells were inhibited via ectopic expression of HLA-E or -G.

[Nature Communications] Scientists provided evidence that embryo-like structures can be generated solely based on transcription factor-mediated reprogramming of embryonic stem cells in a simple 3D co-culture system.