embryonic stem cells

[Biochemical and Biophysical Research Communications] The authors evaluated the migration and distribution of embryonic stem cell-derived MSCs in a model of chemotherapy-induced premature ovarian failure.

[Stem Cell Reviews and Reports] The chromatin accessibility and transcriptional level of human ESCs and human urine cells were compared by Assay for Transposase-Accessible Chromatin with high-throughput sequencing and RNA sequencing RNA-seq to identify potential reprogramming factors.

[Stem Cells] Using human ESCs as well as human iPSCs, investigators demonstrated that the level of reactive oxygen species in pluripotent cells oscillated in accordance with the cell cycle progression with the peak occurring at transition from S to G2/M phase of the cycle.

[Cardiovascular Research] The authors identified CARdiomyocyte Maturation-Associated lncRNA (CARMA), a conserved long non-coding RNA controlling cardiomyocyte differentiation and maturation in human ESCs.

[Nature Communications] Researchers mapped the OCT4 interactomes in naïve and primed human ESCs (hESCs), revealing extensive connections to mammalian ATP-dependent nucleosome remodeling complexes. In naïve hESCs, OCT4 was associated with both BRG1 and BRM, the two paralog ATPases of the BAF complex.

[Nature Communications] Investigators employed a high-throughput cell aggregation approach to simultaneously coax mouse ESCs into hundreds of uniform epiblast-like aggregates in a solid matrix-free manner.