embryonic stem cells

[Development] Using mouse ESCs (mESCs) to recapitulate murine embryonic development, the authors studied the requirement for Notch signaling during the earliest B-lymphopoiesis and found that Rbpj-deficient mESCs were able to generate B-1 cells.

[Genomics Proteomics & Bioinformatics] The authors provided systematic theoretical guidance for optimizing the iPSCs-derived red blood cells differentiation system, which is a useful model for simulating in vivo hematopoietic development and differentiation.

[Reproductive Toxicology] The potential effect of fludioxonil on cardiac differentiation was evaluated in mouse ESCs. Exposure to fludioxonil resulted in reduced size of mouse embryoid bodies and induced increasing expression levels of the pluripotency markers Oct4, Sox2 and Nanog.

[Journal of Molecular Cell Biology] The authors introduced the most recent advances of human embryonic stem cell- or induced pluripotent stem cell-derived organoids to model 3D neuromuscular junctions.

[Nature Communications] Scientists showed that the chromatin and 3D structural features of poised enhancers were conserved among mouse PSCs both in vitro and in vivo.

[npj Parkinson's Disease] Trophoblast Glycoprotein Is a Marker for Efficient Sorting of Ventral Mesencephalic Dopaminergic Precursors Derived from Human Pluripotent Stem Cells-targeted cell sorting enriched FOXA2+LMX1A+ vmDA precursors and helped attain efficient behavioral recovery of rodent Parkinson’s disease models with increased numbers of TH+, NURR1+, and PITX3+ vmDA neurons in the grafts.