embryonic stem cells

[Pharmaceuticals] By analyzing each stage of the drug discovery and development process, scientists identified the active role of human PSC-derived in vitro models in phenotypic screening, target-based screening, target validation, toxicology evaluation, precision medicine, clinical trial in a dish, and post-clinical studies.

[Stem Cells] Investigators probed the effect of the Zbtb46 transcription factor in ESC-derived blood cell progenitors using chemically inducible mouse cell lines.

[Scientific Reports] Simplified conditions will facilitate the use of bovine ESCs for gene editing applications and pluripotency and lineage commitment studies.

[eLife] Researchers discovered crosstalk between AMPA/Kainate-type ionotropic glutamate receptors and the Wnt-pathway during the initial Wnt3a-interaction at the cytonemes of mouse ESCs. In this study, they demonstrated that this crosstalk persisted throughout the Wnt3a-response in ESCs.

[Nature Communications] Scientists identified the epigenetic protein MPP8 as being essential for ground-state pluripotency. Its depletion leads to cell cycle arrest and spontaneous differentiation.

[Stem Cells and Development] CRISPR/Cas9-mediated individual or compound deletion of the two enhancers significantly inhibited HoxB gene expression, and transcriptome analysis revealed that retinoic acid-induced early ESCs differentiation was blocked in the enhancer KO cells.