embryonic stem cells

[Cell Stem Cell] Researchers reported the discovery of human 8-cell (8C)-like cells among naive ESCs, which transcriptionally resembled the 8C human embryo.

[Nature Communications] Scientists found that Dicer-deficient ESCs had strong proliferation and chromosome segregation defects as well as increased transcription of centromeric satellite repeats, which triggered the interferon response.

[Stem Cell Research & Therapy] The authors describe the reconstitution of primordial germ cells and the subsequent meiosis, as well as the signaling pathways and factors involved in these processes.

[Science Advances] Oct4 linker mutant ESCs showed decreased expression of self-renewal genes and increased expression of differentiation genes, resulting in impaired ESC self-renewal and early embryonic development.

[Cell Stem Cell] Scientists performed whole-genome sequencing of 143 hESC lines and annotated their single-nucleotide and structural genetic variants.

[Cell Reports] Aneuploidy, defective differentiation, and inactivation of the tumor suppressor TP53 all occur frequently during tumorigenesis. Researchers probed the potential links among these cancer traits by inactivating TP53 in hESCs.