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endothelial cells

Interplay of Vascular Endothelial Growth Factor Receptors in Organ-Specific Vessel Maintenance

[Journal of Experimental Medicine] Researchers showed that vascular regression induced by VEGFR2 deletion in postnatal and adult mice was aggravated by additional deletion of VEGFR1 or VEGFR3 in the intestine, kidney, and pancreas, but not in the liver or kidney glomeruli.

Correction of a Factor VIII Genomic Inversion with Designer-Recombinases

[Nature Communications] Transient recombinase system treatment of endothelial cells, differentiated from patient-derived induced pluripotent stem cells of a hemophilic donor, resulted in 12% correction of the inversion and restored Factor VIII mRNA expression.

Hypoxia Increases the Potential for Neutrophil-Mediated Endothelial Damage in COPD

[American Journal of Respiratory and Critical Care Medicine] The healthy human neutrophil secretome generated under normoxic or hypoxic conditions was characterized by quantitative mass spectrometry, and the capacity for neutrophil-mediated endothelial damage assessed.

Histone Variant macroH2A1.1 Enhances Non-homologous End Joining-Dependent DNA Double-Strand-Break Repair and Reprogramming Efficiency of Human iPSCs

[Stem Cells] Researchers evaluated the splicing isoforms of histone variant macroH2A1, macroH2A1.1 and macroH2A1.2, as potential regulators of DNA damage repair during iPSC reprogramming.

Alginate/Gelatin-Based Hydrogel with Soy Protein/ Peptide Powder for 3D Printing Tissue-Engineering Scaffolds to Promote Angiogenesis

[Macromolecular Bioscience] Researchers prepared inks that exhibited excellent shear-thinning behavior, which contributed to extrusion-based printing, and also showed good crosslinking ability by calcium chloride.

Development of a Hybrid Nanoink for 3D Bioprinting of Heterogeneous Tumor Models

[ACS Biomaterials Science & Engineering] Scientists reported a hybrid nanoink composed of alginate, gelatin methacryloyl, and cellulose nanocrystal, designed for multinozzle microextrusion 3D printing of tumor models.

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