Complement Activation by an Angiogenic Imbalance Leads to Systemic Vascular Endothelial Dysfunction: A New Proposal for the Pathophysiology of Preeclampsia

Scientists evaluated whether angiogenic imbalance affected the expression and secretion of inhibitory complement factor H in endothelial cells, resulting in complement activation and systemic vascular endothelial dysfunction.
[Journal of Reproductive Immunology]
Matsuyama, T., Tomimatsu, T., Mimura, K., Yagi, K., Kawanishi, Y., Kakigano, A., Nakamura, H., Endo, M., & Kimura, T. (2021). Complement activation by an angiogenic imbalance leads to systemic vascular endothelial dysfunction: A new proposal for the pathophysiology of preeclampsia. Journal of Reproductive Immunology, 145, 103322. https://doi.org/10.1016/j.jri.2021.103322 Cite
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Vascular Dysfunction after Modelled TBI Is Rescued with Administration of Umbilical Cord Derived Mesenchymal Stromal Cells and Is Associated with Modulation of the Angiogenic Response

Investigators hypothesized that the perivascular properties of human umbilical cord perivascular cells could reduce vascular dysfunction after modelled traumatic brain injury by preserving the pericyte-endothelial interactions.
[Journal of Neurotrauma]
Barretto, T., Park, E., Telliyan, T., Liu, E., Gallagher, D., Librach, C., & Baker, A. (2021). Vascular dysfunction after modelled TBI is rescued with administration of umbilical cord derived mesenchymal stromal cells and is associated with modulation of the angiogenic response. Journal of Neurotrauma. https://doi.org/10.1089/neu.2021.0158 Cite
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Scaffolds from Self-Assembling Tetrapeptides Support 3D Spreading, Osteogenic Differentiation, and Angiogenesis of Mesenchymal Stem Cells

The authors describe self-assembling tetrapeptide scaffolds for the growth and osteogenic differentiation of human MSCs. The rationally designed peptides are synthetic amphiphilic self-assembling peptides composed of four amino acids that are nontoxic.
[Biomacromolecules]
Alshehri, S., Susapto, H. H., & Hauser, C. A. E. (2021). Scaffolds from Self-Assembling Tetrapeptides Support 3D Spreading, Osteogenic Differentiation, and Angiogenesis of Mesenchymal Stem Cells. Biomacromolecules. https://doi.org/10.1021/acs.biomac.1c00205 Cite
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Blood–Brain Barrier Opening by Intracarotid Artery Hyperosmolar Mannitol Induces Sterile Inflammatory and Innate Immune Responses

Proteomic changes occurred within five min of intracarotid arterial hyperosmolar mannitol (ICAHM) infusion and returned to baseline by 96 hours. Transcriptomic analyses following ICAHM blood–brain barrier disruption further supported an sterile inflammatory response.
[Proceedings of the National Academy of Sciences of the United States of America]
Burks, S. R., Kersch, C. N., Witko, J. A., Pagel, M. A., Sundby, M., Muldoon, L. L., Neuwelt, E. A., & Frank, J. A. (2021). Blood–brain barrier opening by intracarotid artery hyperosmolar mannitol induces sterile inflammatory and innate immune responses. Proceedings of the National Academy of Sciences, 118(18). https://doi.org/10.1073/pnas.2021915118 Cite
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Endothelial Cell Invasion Is Controlled by Dactylopodia

Researchers showed that endothelial tip cells use dactylopodia as the main cellular protrusion for invasion into nonvascular extracellular matrix. They showed that dactylopodia and filopodia protrusions were balanced by myosin IIA and actin-related protein 2/3 activity.
[Proceedings of the National Academy of Sciences of the United States of America]
Figueiredo, A. M., Barbacena, P., Russo, A., Vaccaro, S., Ramalho, D., Pena, A., Lima, A. P., Ferreira, R. R., Fidalgo, M. A., El-Marjou, F., Carvalho, Y., Vasconcelos, F. F., Lennon-Duménil, A.-M., Vignjevic, D. M., & Franco, C. A. (2021). Endothelial cell invasion is controlled by dactylopodia. Proceedings of the National Academy of Sciences, 118(18). https://doi.org/10.1073/pnas.2023829118 Cite
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Total and Endothelial Cell-Derived Cell-Free DNA in Blood Plasma Does Not Change during Menstruation

The authors measured total cell free (cf)DNA by targeting ALU repetitive sequences and measured endothelial-derived cfDNA by methylation-specific qPCR targeting an endothelium-unique unmethylated CDH5 DNA region.
[PLoS One]
Yuwono, N. L., Henry, C. E., Ford, C. E., & Warton, K. (2021). Total and endothelial cell-derived cell-free DNA in blood plasma does not change during menstruation. PLOS ONE, 16(4), e0250561. https://doi.org/10.1371/journal.pone.0250561 Cite
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A Novel Hypothesis and Characterization to Isolate Microvascular Endothelial Cells Simultaneously with Adipose-Derived Stem Cells from the Human Adipose-Derived Stromal Vascular Fraction

To isolate adipose-derived human microvascular endothelial cells, scientists analyzed the supernatant discarded when adipose stem cells is isolated from the adipose-derived stromal vascular fraction.
[Tissue Engineering and Regenerative Medicine]
Ryu, Y. H., Moon, S.-H., Kim, K. J., Jun, Y. J., Oh, D. Y., Kim, S., & Rhie, J.-W. (2021). A Novel Hypothesis and Characterization to Isolate Microvascular Endothelial Cells Simultaneously with Adipose-Derived Stem Cells from the Human Adipose-Derived Stromal Vascular Fraction. Tissue Engineering and Regenerative Medicine. https://doi.org/10.1007/s13770-021-00332-5 Cite
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Apatinib Suppresses the Migration, Invasion and Angiogenesis of Hepatocellular Carcinoma Cells by Blocking VEGF and PI3K/AKT Signaling Pathways

Apatinib was used to treat hepatocellular carcinoma (HCC) cells transfected with or without VEGFR2 overexpression vectors. The proliferation of HCC cells was detected by MTT assay.
[Molecular Medicine Reports]
Song, J., Guan, Z., Song, C., Li, M., Gao, Z., & Zhao, Y. (2021). Apatinib suppresses the migration, invasion and angiogenesis of hepatocellular carcinoma cells by blocking VEGF and PI3K/AKT signaling pathways. Molecular Medicine Reports, 23(6), 1–8. https://doi.org/10.3892/mmr.2021.12068 Cite
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Bioactive Decellularized Extracellular Matrix Derived from 3D Stem Cell Spheroids under Macromolecular Crowding Serves as a Scaffold for Tissue Engineering

3D decellularized extracellular matrix scaffolds derived from MSC spheroids and with intricate matrix composition were developed.
[Advanced Healthcare Materials]
Chiang, C.-E., Fang, Y.-Q., Ho, C.-T., Assunção, M., Lin, S.-J., Wang, Y.-C., Blocki, A., & Huang, C.-C. (n.d.). Bioactive Decellularized Extracellular Matrix Derived from 3D Stem Cell Spheroids under Macromolecular Crowding Serves as a Scaffold for Tissue Engineering. Advanced Healthcare Materials, n/a(n/a), 2100024. https://doi.org/https://doi.org/10.1002/adhm.202100024 Cite
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Transcriptomic Analysis of CFTR-Impaired Endothelial Cells Reveals a Pro-Inflammatory Phenotype

Investigators used an unbiased RNA sequencing approach in complementary models of cystic fibrosis transmembrane conductance regulator (CFTR) silencing and blockade in human endothelial cells to characterise the changes upon CFTR impairment.
[European Respiratory Journal]
Declercq, M., Zeeuw, P. de, Conchinha, N. V., Geldhof, V., Ramalho, A. S., García-Caballero, M., Brepoels, K., Ensinck, M., Carlon, M. S., Bird, M. J., Vinckier, S., Proesmans, M., Vermeulen, F., Dupont, L., Ghesquière, B., Dewerchin, M., Carmeliet, P., Cassiman, D., Treps, L., … Witters, P. (2021). Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype. European Respiratory Journal, 57(4). https://doi.org/10.1183/13993003.00261-2020 Cite
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Loss of Endothelial Glucocorticoid Receptor Accelerates Diabetic Nephropathy

The fibrogenic phenotype in the kidneys of diabetic mice lacking endothelial glucocorticoid receptor was associated with aberrant cytokine and chemokine reprogramming, augmented Wnt signaling and suppression of fatty acid oxidation.
[Nature Communications]
Srivastava, S. P., Zhou, H., Setia, O., Liu, B., Kanasaki, K., Koya, D., Dardik, A., Fernandez-Hernando, C., & Goodwin, J. (2021). Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy. Nature Communications, 12(1), 2368. https://doi.org/10.1038/s41467-021-22617-y Cite
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