The Histone Lysine Methyltransferase SETD8 Regulates Angiogenesis through HES-1 in Human Umbilical Vein Endothelial Cells

The authors showed that BVT-948-mediated SETD8 inhibition in HUVECs resulted in an inhibition of angiogenesis. Inhibition of SETD8 not only inhibited angiogenesis but also disrupted actin stress fiber formation and induced cell cycle arrest at S phase.
[Scientific Reports]
Choi, D. K., Kim, Y. K., Park, S. W., Lee, H., Lee, S., Kim, S. A., … Yu, J. H. (2020). The histone lysine methyltransferase SETD8 regulates angiogenesis through HES-1 in human umbilical vein endothelial cells. Scientific Reports, 10(1), 12089. https://doi.org/10.1038/s41598-020-69103-x Cite
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Reduced Intracellular Chloride Concentration Impairs Angiogenesis by Inhibiting Oxidative Stress-Mediated VEGFR2 Activation

Investigators showed that reduction of [Cl−]i inhibited HUVEC proliferation, migration, cytoskeleton reorganization, tube formation, and subsequently suppressed angiogenesis under basal condition, and VEGF stimulation or hypoxia treatment.
[Acta Pharmacologica Sinica]
Li, K., Liu, Y., Lv, X., Lin, Z., Zhang, T., Zhang, F., Guo, J., Hong, Y., Liu, X., Lin, X., Zhou, J., Wu, Q., Liang, S., & Shang, J. (2020). Reduced intracellular chloride concentration impairs angiogenesis by inhibiting oxidative stress-mediated VEGFR2 activation. Acta Pharmacologica Sinica, 1–13. https://doi.org/10.1038/s41401-020-0458-7 Cite
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Mitochondrial Respiration Controls Neoangiogenesis during Wound Healing and Tumor Growth

Scienitsts assessed the impact of mitochondrial bioenergetics on neovascularisation, by deleting cox10 gene encoding an assembly factor of cytochrome c oxidase specifically in mouse endothelial cells providing a model for vasculature-restricted respiratory deficiency.
[Nature Communications]
Schiffmann, L. M., Werthenbach, J. P., Heintges-Kleinhofer, F., Seeger, J. M., Fritsch, M., Günther, S. D., Willenborg, S., Brodesser, S., Lucas, C., Jüngst, C., Albert, M. C., Schorn, F., Witt, A., Moraes, C. T., Bruns, C. J., Pasparakis, M., Krönke, M., Eming, S. A., Coutelle, O., & Kashkar, H. (2020). Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth. Nature Communications, 11(1), 3653. https://doi.org/10.1038/s41467-020-17472-2 Cite
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A Greater Burden of Atrial Fibrillation Is Associated with Worse Endothelial Dysfunction in Hypertension

Researchers hypothesised that atrial fibrillation (AF) would further worsen endothelium-dependent flow-mediated dilatation in hypertension patients compared to those without AF.
[Journal of Human Hypertension]
Khan, A. A., Junejo, R. T., Alsharari, R., Thomas, G. N., Fisher, J. P., & Lip, G. Y. H. (2020). A greater burden of atrial fibrillation is associated with worse endothelial dysfunction in hypertension. Journal of Human Hypertension, 1–11. https://doi.org/10.1038/s41371-020-0383-8 Cite
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Pro-Angiogenic Scaffold-Free Bio Three-Dimensional Conduit Developed from Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Promotes Peripheral Nerve Regeneration

Researchers investigated the efficacy and mechanism of the Bio 3D conduit composed of xeno-free human induced pluripotent stem cell–derived mesenchymal stem cells.
[Scientific Reports]
Mitsuzawa, S., Zhao, C., Ikeguchi, R., Aoyama, T., Kamiya, D., Ando, M., Takeuchi, H., Akieda, S., Nakayama, K., Matsuda, S., & Ikeya, M. (2020). Pro-angiogenic scaffold-free Bio three-dimensional conduit developed from human induced pluripotent stem cell-derived mesenchymal stem cells promotes peripheral nerve regeneration. Scientific Reports, 10(1), 12034. https://doi.org/10.1038/s41598-020-68745-1 Cite
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Mesenchymal Stromal Cell‐Derived Factors Promote the Colonization of Collagen 3D Scaffolds with Human Skin Cells

Scientists investigated whether the therapeutic potential of an acellular porous scaffold made of type I collagen could be improved by the addition of a powerful trophic agent in the form of mesenchymal stromal cells conditioned medium in order to be used as an acellular scaffold for skin wound healing treatment.
[Journal of Cellular and Molecular Medicine]
Tutuianu, R., Rosca, A.-M., Kaya, M. G. A., Pruna, V., Neagu, T. P., Lascar, I., Simionescu, M., & Titorencu, I. (n.d.). Mesenchymal stromal cell-derived factors promote the colonization of collagen 3D scaffolds with human skin cells. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15507 Cite
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Biological Functions of Lymphatic Vessels

The authors discuss recent advances to understand previously unidentified functions of adult mammalian lymphatic vessels, including immunosurveillance.
[Science]
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Vascular Contributions to 16p11.2 Deletion Autism Syndrome Modeled in Mice

Researchers showed that there was defective angiogenesis in primary 16p11.2df/+ mouse brain endothelial cells and in induced-pluripotent-stem-cell-derived endothelial cells from human carriers of the 16p11.2 deletion.
[Nature Neuroscience]
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Circ-ADAM9 Targeting PTEN and ATG7 Promotes Autophagy and Apoptosis of Diabetic Endothelial Progenitor Cells by Sponging Mir-20a-5p

Scientists investigated the roles of mir-20a-5p and its predicted target circ-ADAM9 in endothelial progenitor cells treated with high glucose and in a diabetic mouse hind limb ischemia model.
[Cell Death & Disease]
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Lactate Released by Inflammatory Bone Marrow Neutrophils Induces Their Mobilization via Endothelial GPR81 Signaling

Researchers report that bacterial lipopolysaccharides or Salmonella typhimurium triggered lactate release by increasing glycolysis, NADPH-oxidase-mediated reactive oxygen species and HIF-1α levels in bone marrow neutrophils.
[Nature Communications]
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The Pharmaceutical Solvent N-Methyl-2-Pyrollidone (NMP) Attenuates Inflammation through Krüppel-Like Factor 2 Activation to Reduce Atherogenesis

The authors found that N-methyl-2-pyrrolidone attenuated monocyte adhesion to endothelial cells inflamed with tumor necrosis factor alpha by reducing expression of adhesion molecules.
[Scientific Reports]
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The Bartonella Autotransporter BafA Activates the Host VEGF Pathway to Drive Angiogenesis

BafA interacts with vascular endothelial growth factor (VEGF) receptor-2 and activated the downstream signaling pathway, suggesting that BafA functioned as a VEGF analog.
[Nature Communications]
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