Human Cardiac Stem Cells Rejuvenated by Modulating Autophagy with MHY-1685 Enhance the Therapeutic Potential for Cardiac Repair

Scientists employed MHY-1685, a novel mammalian target of rapamycin inhibitor, and examined its long-term priming effect on the activities of senile human cardiac stem cells (hCSCs) and the functional benefits of primed hCSCs after transplantation.
[Experimental and Molecular Medicine]
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Intravenous Injection of Cyclophilin a Realizes the Transient and Reversible Opening of Barrier of Neural Vasculature through Basigin in Endothelial Cells

Researchers demonstrated that the administration of cyclophilin A, a ligand of basigin which was expressed in barrier-forming endothelial cells, realized the artificial opening of blood–brain barrier.
[Scientific Reports]
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Blood and Immune Development in Human Fetal Bone Marrow and Down Syndrome

Hematopoietic progenitors from fetal liver, fetal bone marrow and cord blood exhibited transcriptional and functional differences that contributed to tissue-specific identity and cellular diversification.
[Nature]
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The Importance of Endothelial Protection: The Emerging Role of Defibrotide in Reversing Endothelial Injury and Its Sequelae

Further preclinical and clinical studies will explore defibrotide’s potential utility in a broader range of disorders resulting from endothelial cell activation and dysfunction.
[Bone Marrow Transplantation]
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Osteogenic and Angiogenic Profiles of the Palatal Process of the Maxilla and the Palatal Process of the Palatine Bone

The authors found that the period in which avascular mesenchymal condensation became a vascularized bone structure corresponded to embryonic day 14.5 to embyronic day 16.5 in the hard palate.
[Journal of Anatomy]
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Co-Delivery of Fibrin-Laminin Hydrogel with Mesenchymal Stem Cell Spheroids Supports Skeletal Muscle Regeneration Following Trauma

MSC aggregation into spheroids was optimized in vitro based on cellular viability, spheroid size, and trophic factor secretion. The regenerative potential of the optimized MSC spheroid therapy was then investigated in a murine model of volumetric muscle loss injury.
[Tissue Engineering and Regenerative Medicine]
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Spred1 Deficit Promotes Treatment Resistance and Transformation of Chronic Phase CML

Spred1 knockout, regardless if occurred in HSCs or in endothelial cells, increased miR-126 in LinSca-1+c-Kit+, a population enriched in leukemic stem cells (LSCs), resulting in expansion of LSCs, likely through hyperactivation of the MAPK/ERK pathway that augmented Bcl-2 expression and stability.
[Leukemia]
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Receptor and Molecular Mechanism of AGGF1 Signaling in Endothelial Cell Functions and Angiogenesis

Researchers identified integrin α5β1 as an EC receptor for AGGF1 and a novel AGGF1-mediated signaling pathway of α5β1-FAK-Src-AKT for angiogenesis.
[Arteriosclerosis Thrombosis & Vascular Biology]
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Exosomal OTULIN from M2 Macrophages Promotes the Recovery of Spinal Cord Injuries via Stimulating Wnt/β-Catenin Pathway-Mediated Vascular Regeneration

Researchers determined that M2-Exos could augment the angiogenic activities of spinal cord microvascular endothelial cells in vitro.
[Acta Biomaterialia]
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Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension

In human endothelial cells, a striking correlation was observed between the degree of endothelial cell activation as reflected by intracellular adhesion molecule 1, isoLG-adduct accumulation and intracellular GAS6 levels.
[Circulation Research]
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An Unusual Nicotinamide Derivative, 4-Pyridone-3-Carboxamide Ribonucleoside (4PYR), Is a Novel Endothelial Toxin and Oncometabolite

Lung metastasis and endothelial function were analyzed together with blood nucleotides, plasma amino acids, nicotinamide metabolites, and vascular ectoenzymes of nucleotide catabolism.
[Experimental & Molecular Medicine]
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