Modeling Aortic Diseases using Induced Pluripotent Stem Cells

The authors summarize the patient iPSC‐derived aortic cells that have been utilized to model aortic diseases in vitro.
[Stem Cells Translational Medicine]
Zhu, K., Ma, W., Li, J., Zhang, Y. S., Zhang, W., Lai, H., & Wang, C. (n.d.). Modeling aortic diseases using induced pluripotent stem cells. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/sctm.20-0322 Cite
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Vascular Calcification: New Insights into Endothelial Cells

The authors explore the relationship between endothelial cells and vascular calcification and to provide a theoretical basis and new ideas for the active prevention and treatment of vascular calcification in the clinic.
[Microvascular Research]
Yuan, C., Ni, L., Zhang, C., Hu, X., & Wu, X. (2020). Vascular Calcification: New Insights into Endothelial Cells. Microvascular Research, 104105. https://doi.org/10.1016/j.mvr.2020.104105 Cite
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Soluble Epoxide Hydrolase Inhibitors Improve Angiogenic Function of Endothelial Progenitor Cells via ERK/p38-Mediated miR-126 Upregulation in Myocardial Infarction Mice after Exercise

Mice were subjected to exercise training for four weeks. Bone marrow-derived endothelial progenitor cells (EPCs) were isolated and cultured in vitro. Exercise upregulated miR-126 expression but downregulated the protein levels of its target gene, Spred1, in EPCs from myocardial infarctionmice.
[Experimental Cell Research]
Gui, Y., Chen, J., Hu, J., Liao, C., Ouyang, M., Deng, L., Yang, J., & Xu, D. (2020). Soluble epoxide hydrolase inhibitors improve angiogenic function of endothelial progenitor cells via ERK/p38-mediated miR-126 upregulation in myocardial infarction mice after exercise. Experimental Cell Research, 397(2), 112360. https://doi.org/10.1016/j.yexcr.2020.112360 Cite
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RNA Sequencing Reveals BMP4 as a Basis for the Dual-Target Treatment of Diabetic Retinopathy

Researchers explored the pathogenesis of diabetic retinopathand identified new treatments that can provide dual-target intervention for angiogenesis and fibrosis. They explored changes in gene expression in high glucose–induced vascular endothelial cells using RNA sequencing technology.
[International Journal of Molecular Medicine]
Dong, L., Zhang, Z., Liu, X., Wang, Q., Hong, Y., Li, X., & Liu, J. (2020). RNA sequencing reveals BMP4 as a basis for the dual-target treatment of diabetic retinopathy. Journal of Molecular Medicine. https://doi.org/10.1007/s00109-020-01995-8 Cite
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The Protective Effects of Tripeptides VPP and IPP against Small Extracellular Vesicles from Angiotensin II-Induced Vascular Smooth Muscle Cells Mediating Endothelial Dysfunction in Human Umbilical Vein Endothelial Cells

Scientists investigated whether the antihypertensive peptides Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP) ameliorate the effects of extracellular vesicles from Ang II-induced vascular smooth muscles on the endothelial dysfunction.
[Journal of Agricultural and Food Chemistry]
Song, T., Lv, M., Zhang, L., Zhang, X., Song, G., Huang, M., Zheng, L., & Zhao, M. (2020). The Protective Effects of Tripeptides VPP and IPP against Small Extracellular Vesicles from Angiotensin II-Induced Vascular Smooth Muscle Cells Mediating Endothelial Dysfunction in Human Umbilical Vein Endothelial Cells. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.0c05698 Cite
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Geometry Influences Inflammatory Host Cell Response and Remodeling in Tissue-Engineered Heart Valves In Vivo

Scientists performed an in-depth qualitative and quantitative (immuno-)histological analysis focusing on key-players of the inflammatory and remodeling cascades. First-generation tissue-engineered matrix-based heart valves were prone to chronic inflammation, showing a high presence of macrophages and α-SMA+-cells, hinge-area thickening, and delayed endothelialization.
[Scientific Reports]
Motta, S. E., Fioretta, E. S., Lintas, V., Dijkman, P. E., Hilbe, M., Frese, L., Cesarovic, N., Loerakker, S., Baaijens, F. P. T., Falk, V., Hoerstrup, S. P., & Emmert, M. Y. (2020). Geometry influences inflammatory host cell response and remodeling in tissue-engineered heart valves in-vivo. Scientific Reports, 10(1), 19882. https://doi.org/10.1038/s41598-020-76322-9 Cite
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Coadministration of Endothelial and Smooth Muscle Cells Derived from Human Induced Pluripotent Stem Cells as a Therapy for Critical Limb Ischemia

Investigators explored the therapeutic efficacy of human induced pluripotent stem cell (iPSC)‐derived endothelial cell and iPSC‐derived smooth muscle cell in peripheral artery disease model.
[Stem Cells Translational Medicine]
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VCAM‐1‐Targeted Gene Delivery Nanoparticles Localize to Inflamed Endothelial Cells and Atherosclerotic Plaques

An anti‐inflammatory gene therapy nanoparticle targeted to VCAM‐1, a protein overexpressed by inflamed endothelial cells located within atherosclerotic plaque, was developed.
[Advanced Therapeutics]
Distasio, N., Salmon, H., Dierick, F., Ebrahimian, T., Tabrizian, M., & Lehoux, S. (n.d.). VCAM-1-Targeted Gene Delivery Nanoparticles Localize to Inflamed Endothelial Cells and Atherosclerotic Plaques. Advanced Therapeutics, n/a(n/a), 2000196. https://doi.org/https://doi.org/10.1002/adtp.202000196 Cite
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Transport Properties of Statins by OATP1A2 and Regulation by Transforming Growth Factor-β (TGF-β) Signaling in Human Endothelial Cells

Cellular uptake and monolayer permeability of atorvastatin, pravastatin, and rosuvastatin were investigated, in vitro, using HUVECs.
[Journal of Pharmacology and Experimental Therapeutics]
Ronaldson, P. T., Brzica, H., Abdullahi, W., Reilly, B. G., & Davis, T. P. (2020). Transport Properties of Statins by OATP1A2 and Regulation by Transforming Growth Factor-β (TGF-β) Signaling in Human Endothelial Cells. Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1124/jpet.120.000267 Cite
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Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection

Endothelial cells were isolated from human brain and analyzed by RNA sequencing. Human umbilical vein and human brain microvascular cells were used in both monolayer culture and endothelialized within a 3-dimensional printed vascular model of the middle cerebral artery.
[Stroke]
Kaneko Naoki, Satta Sandro, Komuro Yutaro, Muthukrishnan Sree Deepthi, Kakarla Visesha, Guo Lea, An Jennifer, Elahi Fanny, Kornblum Harley I., Liebeskind David S., Hsiai Tzung, & Hinman Jason D. (n.d.). Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection. Stroke, 0(0), STROKEAHA.120.032764. https://doi.org/10.1161/STROKEAHA.120.032764 Cite
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Endothelial p300 Promotes Portal Hypertension and Hepatic Fibrosis through CCL2-Mediated Angiocrine Signaling

In vitro, epigenome‐editing of carbon tetrachloride (CCL2) enhancer and promoter regions by CRISPR‐dCas9‐KRAB technology repressed TNFα‐induced CCL2 transcription via H3K9 tri‐methylation.
[Hepatology]
Gao, J., Wei, B., Liu, M., Hirsova, P., Sehrawat, T. S., Cao, S., Hu, X., Xue, F., Yaqoob, U., Kang, N., Cui, H., Pomerantz, W. C. K., Kostallari, E., & Shah, V. H. (n.d.). Endothelial p300 promotes portal hypertension and hepatic fibrosis through CCL2-mediated angiocrine signaling. Hepatology, n/a(n/a). https://doi.org/https://doi.org/10.1002/hep.31617 Cite
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