endothelial cells

[Circulation Research] Electrophysiological analyses confirmed expression and function of Piezo1 channels in brain cortical and retinal capillaries. Activation of Piezo1 channels evoked currents that were sensitive to endothelial cell–specific Piezo1 deletion.

[Open Biology] Scientists showed that the deficiency of miRNA-22a, an endothelial-enriched miRNA, caused dramatic pathfinding defects both in intersegmental vessels and primary motor neurons in zebrafish embryos.

[Scientific Reports] Investigators described an innovative screening platform for identification of new blood–brain barrier targeting molecules from a class of lamprey antigen recognition proteins known as variable lymphocyte receptors.

[Communications Biology] Scientists used single-cell RNA sequencing to explore the transcriptomic landscape of mid- and advanced-stage alcohol-induced osteonecrosis of the femoral head.

[Scientific Reports] Researchers elucidated the overall smoking-induced miRNA changes and those specific to chronic obstructive pulmonary disease (COPD).They investigated the downstream effects on regulatory gene expression and the correlation to cellular composition.

[Cellular and Molecular Life Sciences] Cultured HUVECs were exposed to laminar or non-laminar shear stres. Epithelial Na+ channel membrane insertion was quantified using Quantum-dot-based immunofluorescence staining and the mechanical properties of the cell surface were probed with the Atomic Force Microscope in vitro and ex vivo in isolated aortae of C57BL/6 and ApoE/LDLR-/- mice.