The authors summarize the patient iPSC‐derived aortic cells that have been utilized to model aortic diseases in vitro.
[Stem Cells Translational Medicine]
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Zhu, K., Ma, W., Li, J., Zhang, Y. S., Zhang, W., Lai, H., & Wang, C. (n.d.). Modeling aortic diseases using induced pluripotent stem cells. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/sctm.20-0322 Cite
The authors explore the relationship between endothelial cells and vascular calcification and to provide a theoretical basis and new ideas for the active prevention and treatment of vascular calcification in the clinic.
Mice were subjected to exercise training for four weeks. Bone marrow-derived endothelial progenitor cells (EPCs) were isolated and cultured in vitro. Exercise upregulated miR-126 expression but downregulated the protein levels of its target gene, Spred1, in EPCs from myocardial infarctionmice.
[Experimental Cell Research]
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Gui, Y., Chen, J., Hu, J., Liao, C., Ouyang, M., Deng, L., Yang, J., & Xu, D. (2020). Soluble epoxide hydrolase inhibitors improve angiogenic function of endothelial progenitor cells via ERK/p38-mediated miR-126 upregulation in myocardial infarction mice after exercise. Experimental Cell Research, 397(2), 112360. https://doi.org/10.1016/j.yexcr.2020.112360 Cite
Researchers explored the pathogenesis of diabetic retinopathand identified new treatments that can provide dual-target intervention for angiogenesis and fibrosis. They explored changes in gene expression in high glucose–induced vascular endothelial cells using RNA sequencing technology.
[International Journal of Molecular Medicine]
Scientists investigated whether the antihypertensive peptides Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP) ameliorate the effects of extracellular vesicles from Ang II-induced vascular smooth muscles on the endothelial dysfunction.
[Journal of Agricultural and Food Chemistry]
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Song, T., Lv, M., Zhang, L., Zhang, X., Song, G., Huang, M., Zheng, L., & Zhao, M. (2020). The Protective Effects of Tripeptides VPP and IPP against Small Extracellular Vesicles from Angiotensin II-Induced Vascular Smooth Muscle Cells Mediating Endothelial Dysfunction in Human Umbilical Vein Endothelial Cells. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.0c05698 Cite
Scientists performed an in-depth qualitative and quantitative (immuno-)histological analysis focusing on key-players of the inflammatory and remodeling cascades. First-generation tissue-engineered matrix-based heart valves were prone to chronic inflammation, showing a high presence of macrophages and α-SMA+-cells, hinge-area thickening, and delayed endothelialization.
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Motta, S. E., Fioretta, E. S., Lintas, V., Dijkman, P. E., Hilbe, M., Frese, L., Cesarovic, N., Loerakker, S., Baaijens, F. P. T., Falk, V., Hoerstrup, S. P., & Emmert, M. Y. (2020). Geometry influences inflammatory host cell response and remodeling in tissue-engineered heart valves in-vivo. Scientific Reports, 10(1), 19882. https://doi.org/10.1038/s41598-020-76322-9 Cite
Investigators explored the therapeutic efficacy of human induced pluripotent stem cell (iPSC)‐derived endothelial cell and iPSC‐derived smooth muscle cell in peripheral artery disease model.
[Stem Cells Translational Medicine]
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An anti‐inflammatory gene therapy nanoparticle targeted to VCAM‐1, a protein overexpressed by inflamed endothelial cells located within atherosclerotic plaque, was developed.
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Distasio, N., Salmon, H., Dierick, F., Ebrahimian, T., Tabrizian, M., & Lehoux, S. (n.d.). VCAM-1-Targeted Gene Delivery Nanoparticles Localize to Inflamed Endothelial Cells and Atherosclerotic Plaques. Advanced Therapeutics, n/a(n/a), 2000196. https://doi.org/https://doi.org/10.1002/adtp.202000196 Cite
Cellular uptake and monolayer permeability of atorvastatin, pravastatin, and rosuvastatin were investigated, in vitro, using HUVECs.
[Journal of Pharmacology and Experimental Therapeutics]
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Ronaldson, P. T., Brzica, H., Abdullahi, W., Reilly, B. G., & Davis, T. P. (2020). Transport Properties of Statins by OATP1A2 and Regulation by Transforming Growth Factor-β (TGF-β) Signaling in Human Endothelial Cells. Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1124/jpet.120.000267 Cite
Endothelial cells were isolated from human brain and analyzed by RNA sequencing. Human umbilical vein and human brain microvascular cells were used in both monolayer culture and endothelialized within a 3-dimensional printed vascular model of the middle cerebral artery.
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Kaneko Naoki, Satta Sandro, Komuro Yutaro, Muthukrishnan Sree Deepthi, Kakarla Visesha, Guo Lea, An Jennifer, Elahi Fanny, Kornblum Harley I., Liebeskind David S., Hsiai Tzung, & Hinman Jason D. (n.d.). Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection. Stroke, 0(0), STROKEAHA.120.032764. https://doi.org/10.1161/STROKEAHA.120.032764 Cite
In vitro, epigenome‐editing of carbon tetrachloride (CCL2) enhancer and promoter regions by CRISPR‐dCas9‐KRAB technology repressed TNFα‐induced CCL2 transcription via H3K9 tri‐methylation.
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Gao, J., Wei, B., Liu, M., Hirsova, P., Sehrawat, T. S., Cao, S., Hu, X., Xue, F., Yaqoob, U., Kang, N., Cui, H., Pomerantz, W. C. K., Kostallari, E., & Shah, V. H. (n.d.). Endothelial p300 promotes portal hypertension and hepatic fibrosis through CCL2-mediated angiocrine signaling. Hepatology, n/a(n/a). https://doi.org/https://doi.org/10.1002/hep.31617 Cite