endothelial cells

[International Immunopharmacology] Scientists investigated the anti-inflammatory properties of small extracellular vesicles derived from human umbilical cord MSCs in a diabetic rat model and human retinal microvascular endothelial cells.

[Journal of Cancer Research and Clinical Oncology] Scientists summarize recent advancements of 3D tumor vascular model systems which include tissue engineering-based tumor models; vascular organoid models, and organ-on-chips and their importance in replicating the tumor angiogenesis along with the associated challenges to design improved models.

[Science Translational Medicine] Lung autopsy samples from 18 patients with fatal COVID-19, with symptom onset-to-death times ranging from 3 to 47 days, and antemortem plasma samples from 6 of these cases were evaluated using deep sequencing of SARS-CoV-2 RNA, multiplex plasma protein measurements, and pulmonary gene expression and imaging analyses.

[Acta Pharmacologica Sinica] The authors showed that interrupting TRPV4–Nox2 coupling by TRPV4 knockout, or by treatment with a specific Nox2 inhibitor Nox2 dstat or a specific TRPV4 inhibitor HC067046 significantly attenuated obesity-induced ROS overproduction in aortic endothelial cells, and reversed the abnormal endothelial cytoskeletal structure.

[Scientific Reports] Scientists worked with electrospun nanofiber scaffold named that was composed of polyvinyl alcohol/iota carrageenan and doped with partially reduced graphene oxide that was successfully synthesized for wound healing and skin repair.

[Breast Cancer Research] Researchers showed that fluid forces on the order of 1 Pa promoted epithelial-to-mesenchymal transition and adhesion of breast cancer cells to an endothelial monolayer and identified biomarkers were distinctly expressed in patient populations.