THRIL was upregulated in coronary atherosclerotic heart disease (CAD) blood samples and endothelial progenitor cells (EPCs). Knockdown of THRIL in EPCs promoted cell viability, inhibited cell autophagy and further suppressed the development of CAD.
Monsanto, M. M., Wang, B. J., Ehrenberg, Z. R., Echeagaray, O., White, K. S., Alvarez, R., Fisher, K., Sengphanith, S., Muliono, A., Gude, N. A., & Sussman, M. A. (2020). Enhancing myocardial repair with CardioClusters. Nature Communications, 11(1), 3955. https://doi.org/10.1038/s41467-020-17742-zCite
Flow cytometry demonstrated that irradiation led to a significant reduction in the peripheral blood endothelial progenitor cell (EPC) count; however, EPC transplantation led to a significant increase in the circulating EPCs.