SDF-1 Secreted by Mesenchymal Stem Cells Promotes the Migration of Endothelial Progenitor Cells via CXCR4/PI3K/AKT Pathway

The authors investigated whether stromal cell-derived factor (SDF)-1 secreted by mesenchymal stem cells contributed to endothelial progenitor cell migration to ischemic sites via CXCR4/Phosphoinositide 3-Kinases/protein kinase B signaling pathway.
[Journal of Molecular Histology]
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Long Noncoding RNA p21 Enhances Autophagy to Alleviate Endothelial Progenitor Cells Damage and Promote Endothelial Repair in Hypertension through SESN2/AMPK/TSC2 Pathway

The authors showed that the number of endothelial progenitor cells (EPCs) in hypertensive patients was significantly lower than that of normal population, and the cell function decreased with a higher proportion of EPCs at later stages.
[Pharmacological Research]
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CXCL13/CXCR5 Axis Facilitates Endothelial Progenitor Cell Homing and Angiogenesis during Rheumatoid Arthritis Progression

Rheumatoid arthritis synovial fluid increased endothelial progenitor cell homing and angiogenesis, which was blocked by the CXCL13 antibody.
[Cell Death & Disease]
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Effect of Endothelial Progenitor Cell-Derived Extracellular Vesicles on Endothelial Cell Ferroptosis and Atherosclerotic Vascular Endothelial Injury

Researchers focused on the role of endothelial progenitor cell-secreted extracellular vesicles in atherosclerosis.
[Cell Death Discovery]
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p300/Sp1-Mediated High Expression of p16 Promotes Endothelial Progenitor Cell Senescence Leading to the Occurrence of Chronic Obstructive Pulmonary Disease

Peripheral blood endothelial progenitor cells were isolated from nonsmoking non-chronic obstructive pulmonary disease (COPD), smoking non-COPD, and smoking COPD patients. The expressions of p16, p300, and senescence-related genes were detected by RT-PCR and Western Blot.
[Mediators of Inflammation]
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Mesenchymal Stem Cell and Endothelial Progenitor Cells Coinjection Improves LPS-Induced Lung Injury via Tie2 Activation and Downregulation of the TLR4/MyD88 Pathway

Coinjections of endothelial progenitor cells + mesenchymal stem cells significantly enhanced the survival rate of lipopolysaccharide-induced mice, decreased concentrations of pro-inflammatory cytokines, and increased the level of anti-inflammatory cytokine.
[Journal of Cellular Biochemistry]
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Fenofibrate Increases Circulating Hematopoietic Stem Cells in People with Diabetic Retinopathy: A Randomized, Placebo-Controlled Trial

The authors investigated whether fenofibrate increased circulating hematopoietic stem/progenitor cells (HSPCs). When compared with placebo, fenofibrate significantly increased levels of HSPCs expressing CD34 and/or CD133.
[Diabetologia]
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Adverse Effect of Circadian Rhythm Disorder on Reparative Angiogenesis in Hind Limb Ischemia

Concentrations of plasma vascular endothelial growth factor and circulating endothelial progenitor cells in control mice formed a circadian rhythm, which was diminished in the jet‐lag model.
[Journal of the American Heart Association]
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Effects of Calcitriol on Peripheral Endothelial Progenitor Cells and Renal Renovation in Rats with Chronic Renal Failure

Researchers analyzed the role/number of endothelial progenitor cells, renal function, and pathological alterations in rats with chronic renal failure, and compared the results before and after supplementation with calcitriol in vivo.
[Journal of Steroid Biochemistry and Molecular Biology]
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Endothelial Progenitor Cells Modulate the Phenotype of Smooth Muscle Cells and Increase Their Neointimal Accumulation following Vascular Injury

Researchers examined the influence of endothelial progenitor cells on features of smooth muscle cells pivotal for their impact on injury-induced neointima formation including proliferation, migration, and phenotype switch.
[Thrombosis and Haemostasis]
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Ultrasonic Microbubble VEGF Gene Delivery Improves Angiogenesis of Senescent Endothelial Progenitor Cells

In the ultrasonic microbubble transfection groups, higher pDNA-derived protein expression was found in senescent endothelial progenitor cells (EPCs) than in young EPCs.
[Scientific Reports]
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