Scientists review the potential mechanism of stem cells as new therapeutic agents in the treatment of diabetic nephropathy (DN). They also review recent findings and updated information about not only the utilization of stem cells on DN in both preclinical and clinical trials but limitations and future expectations of stem cell-based therapy for DN.
[Cell Death & Disease]
Scientists characterized of the CD34+ cell population in peripheral blood in patients with sarcoidosis (SA) with reference to the control group. Moreover in patients with SA, fibrocytes and endothelial cells were analyzed and their relationship to the fibrosis process based on assessment of diffusing capacity for carbon monoxide.
[BMC Pulmonary Medicine]
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Mice were subjected to exercise training for four weeks. Bone marrow-derived endothelial progenitor cells (EPCs) were isolated and cultured in vitro. Exercise upregulated miR-126 expression but downregulated the protein levels of its target gene, Spred1, in EPCs from myocardial infarctionmice.
[Experimental Cell Research]
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Gui, Y., Chen, J., Hu, J., Liao, C., Ouyang, M., Deng, L., Yang, J., & Xu, D. (2020). Soluble epoxide hydrolase inhibitors improve angiogenic function of endothelial progenitor cells via ERK/p38-mediated miR-126 upregulation in myocardial infarction mice after exercise. Experimental Cell Research, 397(2), 112360. https://doi.org/10.1016/j.yexcr.2020.112360 Cite
Scientists investigated the proliferation of umbilical cord blood–derived endothelial progenitor cells and the differentiation efficiency toward corneal endothelial cell-like cells induced by rho-associated protein kinase inhibitor Y-27632 and to determine the most effective strategy for repairing corneal endothelium injuries in rabbits.
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Scientists successfully identified isolated endothelial progenitor cells from the peripheral blood of patients with coronary slow flow.
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THRIL was upregulated in coronary atherosclerotic heart disease (CAD) blood samples and endothelial progenitor cells (EPCs). Knockdown of THRIL in EPCs promoted cell viability, inhibited cell autophagy and further suppressed the development of CAD.
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Mesenchymal stem cells, endothelial progenitor cells and c-Kit+ cardiac interstitial cells when cultured together spontaneously formed scaffold-free 3D microenvironments termed CardioClusters.
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Monsanto, M. M., Wang, B. J., Ehrenberg, Z. R., Echeagaray, O., White, K. S., Alvarez, R., Fisher, K., Sengphanith, S., Muliono, A., Gude, N. A., & Sussman, M. A. (2020). Enhancing myocardial repair with CardioClusters. Nature Communications, 11(1), 3955. https://doi.org/10.1038/s41467-020-17742-z Cite
The human HEPC-CB.1 cell line with many characteristics of endothelial progenitor cells was tested for its proangiogenic properties as a potentially therapeutic compound.
[Molecular Biology Reports]
Flow cytometry demonstrated that irradiation led to a significant reduction in the peripheral blood endothelial progenitor cell (EPC) count; however, EPC transplantation led to a significant increase in the circulating EPCs.
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