epidermal stem cells

[Experimental Dermatology] Investigators uncovered COL17 as a binding partner of the aPKC‐PAR complex, which is a key regulating factor of cell polarity. Immunoprecipitation‐immunoblot assay and protein‐protein binding assay revealed that COL17 interacts with aPKC and PAR3. Type XVII collagen (COL17) deficiency or epidermis‐specific aPKCλ deletion destabilized PAR3 distribution in the epidermis, while aPKCζ knockout did not.

[Journal of Internal Medicine] In this review, focusing on the skin, scientists investigate potential key mechanisms that ensure tissue homeostasis despite the presence of mutant cells, as well as critical factors that may nudge the balance from homeostasis to tumor formation.

[Stem Cell Research & Therapy] Functional epidermal three dimensional organoids with polarity were cultured using Wnt3a and the supernatant derived from interfollicular epidermal stem cells and fresh medium in a 1:1 ratio

[Stem Cell Research & Therapy] Adult scalp dermal progenitor cells and epidermal stem cells together with type I collagen as a scaffold material were used to reconstitute bilayer tissue-engineered skin substitutes in vitro.

[Oncogenesis] To investigate whether and how altered MYC phosphorylation might affect squamous cell carcinoma development, progression, and metastasis, scienttists generated mice with inducible expression of MYCWT or MYCT58A in the basal layer of the skin epidermis.

[Proceedings of the National Academy of Sciences of the United States of America] By intersecting lipidomic datasets from suspension-induced differentiation and knockdown keratinocytes, scientists pinpointed candidate bioactive lipid subspecies as differentiation regulators.