Modeling Somatic Mutations Associated with Neurodevelopmental Disorders in Human Brain Organoids

Brain organoids capture the developmental progression of the human brain and contain human-enriched progenitor cell types.
[Frontiers in Molecular Neuroscience]
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KIF5C Deficiency Causes Abnormal Cortical Neuronal Migration, Dendritic Branching, and Spine Morphology in Mice

Investigators observed high KIF5C expression in neurons during the early developmental stage in mice and the human brain. Kif5c deficiency resulted in disturbed cortical neuronal migration, dendritic, and spine growth.
[Pediatric Research]
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Neurogenic and Cognitive Enhancing Effects of Human Dental Pulp Stem Cells and its Secretome in Animal Model of Hippocampal Neurodegeneration

Probing the possible mechanisms of neuroprotection revealed that dental pulp stem cells (DPSCs)/DPSCs-conditioned media treatment upregulated an array of hosts’ endogenous neural survival factors expression.
[Brain Research Bulletin]
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Trevena Announces Advancement of TRV045 Into Clinical Development for Diabetic Neuropathic Pain

Trevena, Inc. announced it is advancing TRV045 into clinical development, following receipt of a notification from the US FDA that the study may proceed.
[Trevena, Inc.]
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Human Stem Cell-Derived GABAergic Neurons Functionally Integrate into Human Neuronal Networks

Researchers provided a proof-of-concept that human embryonic stem cell-derived neurons could integrate and modulate the activity of a human host neuronal network.
[Scientific Reports]
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Ameliorating Effect of Umbilical Cord Mesenchymal Stem Cells in a Human Induced Pluripotent Stem Cell Model of Dravet Syndrome

Investigators evaluated the effects of human umbilical cord mesenchymal stem cell-conditioned medium in a new in vitro model of neurons differentiated from Dravet syndrome patient-derived iPSCs.
[Molecular Neurobiology]
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SynGAP Research Fund Announces $308,000 Multidisciplinary Biomarker Grant to Boston Children’s Hospital

The SynGAP Research Fund announced grants to Drs. April Levin, Mustafa Sahin and Annapurna Poduri of Boston Children’s Hospital to advance SYNGAP1 biomarker characterization and genotype-phenotype analysis.
[SynGAP Research Fund]
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UTSA Brain Health Consortium Awarded $12.5M to Research Genetic Brain Disorders

Brain and stem cell researchers from The University of Texas at San Antonio have secured $12.5 million in funding over five years from the National Institutes of Health through the NIH BRAIN Initiative to advance new methods for studying genetic brain disorders.
[The University of Texas at San Antonio]
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Generation of SCN1B Knock Out Induced Pluripotent Stem Cell (iPSC) Line (Refractory Epilepsy Syndrome and Brugada Syndrome Related Cell Line)

Scientists generated iPSCs from a normal individual by electroporation of peripheral blood mononuclear cells, and further generated a SCN1B-knockout human iPSC line via CRISPR/Cas9 gene editing.
[Stem Cell Research]
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IQSEC2 Mutation Associated with Epilepsy, Intellectual Disability, and Autism Results in Hyperexcitability of Patient-Derived Neurons and Deficient Synaptic Transmission

Investigators used iPSC technology to obtain hippocampal neurons to investigate the neuropathology of IQSEC2-mediated disease. The neurons were characterized at three-time points during differentiation to assess developmental progression.
[Molecular Psychiatry]
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Vyant Bio and Cyclica Announce a Strategic Collaboration to Identify Compounds to Treat CDKL5 Deficiency Disorder

Vyant Bio, Inc. and Cyclica, Inc. announced a non-exclusive strategic collaboration combining Vyant Bio’s patient-derived complex organoid biology alongside Cyclica’s proteome-wide, Artificial Intelligence enabled discovery platform to identify new treatments for CDKL5 Deficiency Disorder, a severe neurodevelopmental epilepsy disorder with no effective treatments or cure.
[Vyant Bio, Inc.]
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