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Altered Adult Neurogenesis and Gliogenesis in Patients with Mesial Temporal Lobe Epilepsy

[Nature Neuroscience] Scientists found that a longer duration of epilepsy was associated with a sharp decline in neuronal production and persistent numbers in astrogenesis.

Valproic Acid Decreases Vascular Smooth Muscle Cell Proliferation via Protein Phosphatase 2A-Mediated p70 S6 Kinase Inhibition

[Biochemical and Biophysical Research Communications] Scientists investigated the molecular mechanism by which valproic acid inhibited rat vascular smooth muscle cell proliferation.

In Vitro Engineered Human Cerebral Tissues Mimic Pathological Circuit Disturbances in 3D

[Communications Biology] By promoting matrix-supported active cell reaggregation, the authors engineered multiregional cerebral tissues with intact 3D neuronal networks and functional interconnectivity characteristic of brain networks.

NPRL3 Loss Alters Neuronal Morphology, mTOR Localization, Cortical Lamination, and Seizure Threshold

[Brain] To model human malformations of cortical development associated with nitrogen permease regulator-like 3 (NPRL3) variants, researchers created a focal Nprl3 KO in fetal mouse cortex by in utero electroporation and found altered cortical lamination and white matter heterotopic neurons

Amplification of Human Interneuron Progenitors Promotes Brain Tumors and Neurological Defects

[Science] Investigators generated a human model for tuberous sclerosis complex (TSC) by growing cerebral organoids from patients who carried mutations in TSC2.

Modeling Somatic Mutations Associated with Neurodevelopmental Disorders in Human Brain Organoids

[Frontiers in Molecular Neuroscience] Brain organoids capture the developmental progression of the human brain and contain human-enriched progenitor cell types.