YIPF5 Mutations Cause Neonatal Diabetes and Microcephaly through Endoplasmic Reticulum Stress

Investigators used three human β cell models to investigate the mechanism through which YIPF5 loss of function affects β cells. Loss of YIPF5 function in stem cell–derived islet cells resulted in proinsulin retention in the ER, marked ER stress, and β cell failure.
[Journal of Clinical Investigation]
Franco, E. D., Lytrivi, M., Ibrahim, H., Montaser, H., Wakeling, M. N., Fantuzzi, F., Patel, K., Demarez, C., Cai, Y., Igoillo-Esteve, M., Cosentino, C., Lithovius, V., Vihinen, H., Jokitalo, E., Laver, T. W., Johnson, M. B., Sawatani, T., Shakeri, H., Pachera, N., … Hattersley, A. T. (2020). YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress. The Journal of Clinical Investigation, 130(12). https://doi.org/10.1172/JCI141455 Cite
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Hyaluronan Regulates Synapse Formation and Function in Developing Neural Networks

Scientists used 3D cortical spheroids derived from human iPSCs to replicate the neurodevelopmental window. Their results demonstrated that hyaluronan preferentially surrounds nascent excitatory synapses.
[Scientific Reports]
Wilson, E., Knudson, W., & Newell-Litwa, K. (2020). Hyaluronan regulates synapse formation and function in developing neural networks. Scientific Reports, 10(1), 16459. https://doi.org/10.1038/s41598-020-73177-y Cite
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The Effects of Microglia‐ and Astrocyte‐Derived Factors on Neurogenesis in Health and Disease

The authors describe how glial cells play a role in adult hippocampal neurogenesis in both health and disease, especially focusing on glia‐derived factors.
[European Journal of Neuroscience]
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Application of Induced Pluripotent Stem Cells in Epilepsy

The authors provide an overview of iPSC lines that have been derived from patients with specific epilepsy types. They discuss the genetic underpinnings and molecular mechanisms of each epilepsy type.
[Molecular and Cellular Neuroscience]
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Astrocytic BDNF and TrkB Regulate Severity and Neuronal Activity in Mouse Models of Temporal Lobe Epilepsy

Specific genetic deletion of BDNF in astrocytes prevented the increase in the number of firing neurons and the global firing rate in an in vitro model of temporal lobe epilepsy.
[Cell Death & Disease]
Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy | Cell Death & Disease. (n.d.). Retrieved June 4, 2020, from https://www.nature.com/articles/s41419-020-2615-9 Cite
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Astrocytic BDNF and TrkB Regulate Severity and Neuronal Activity in Mouse Models of Temporal Lobe Epilepsy

Specific genetic deletion of BDNF in astrocytes prevented the increase in the number of firing neurons and the global firing rate in an in vitro model of temporal lobe epilepsy.
[Cell Death & Disease]
Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy | Cell Death & Disease. (n.d.). Retrieved June 4, 2020, from https://www.nature.com/articles/s41419-020-2615-9 Cite
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